Efficacy of intra-arterial nimodipine therapy in the treatment of vasospasm after subarachnoid hemorrhage

Year 2020, , 213 - 219, 25.06.2020

Vedat Açık

https://doi.org/10.16899/jcm.737704

Abstract

Background: This study aims to investigate the efficacy of intra-arterial nimodipine therapy in treating patients that presented with spontaneous subarachnoid hemorrhage and developed vasospasm following aneurysm surgery.
Methods: The study includes 37 patients that underwent intra-arterial nimodipine therapy for the treatment of cerebral vasospasm between October 2015 and December 2019. In patients that developed vasospasm, a catheter was selectively inserted into the internal carotid artery, 1–2 mg of nimodipine was diluted with 50 ccs of saline, and was slowly infused through the catheter.
Results: In our study, we found the success rate of intra-arterial nimodipine administration to be 78.4% (neurologic findings completely improved in 29 cases). The clinical condition did not improve in 13.5% of cases and worsened in 8.1%. 86.4% of our patients were discharged with good outcomes (mRS score 0–1).
Conclusion: We conclude that intra-arterial nimodipine therapy is a cost-effective, safe, and successful method for the treatment of cerebral vasospasm, a condition that directly affects morbidity and mortality after subarachnoid hemorrhage. Prospective studies are needed to determine standard doses and application times in order to establish the efficacy of intra-arterial nimodipine therapy in treating cerebral vasospasm.

Keywords

spontaneous subarachnoid hemorrhage

Thanks

Dear Editor Enclosed, you will find our manuscript ‘‘Efficacy of intra-arterial nimodipine therapy in the treatment of vasospasm after subarachnoid hemorrhage‘’. Please consider it for publication as an ‘‘Original article’’ in the ‘‘Journal of Contemporary Medicine‘’ and let us know your criticisms. We hereby declare that all authors have made a substantial contribution to the information submitted for publication; all have read and approved the final manuscript and the manuscript or portions are not under consideration by another journal and have not been previously published. We have been guaranteed that the study originality We look forward for a positive outcome. Yours sincerely,

References

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