Review

The effect of Telomere Lengthening on Genetic Diseases

Volume: 11 Number: 2 March 25, 2021
EN

The effect of Telomere Lengthening on Genetic Diseases

Abstract

Abstract Telomeres are a characteristic of chromosomes that have increasingly large significance in research. They are studied in various diseases to discover potential treatment strategies. Their most vital characteristic is their length because the length can be used to describe different characteristics about the cell, such as its age. The length of telomeres can also be used as a potential way to treat disease. This review article’s purpose is to explore how te-lomeres can be potentially used as a method to treat genetic diseases such as trisomy 21 and cancer.

Keywords

References

  1. 1. Albizua, I et al. “Association between telomere length and chromosome 21 nondisjunc-tion in the oocyte.” Human genetics vol. 134,11-12 (2015): 1263-70. doi:10.1007/s00439-015-1603-0
  2. 2. Honig L.S., Kang M.S., Schupf N., Lee J.H., and Mayeux R. (2012). Association of shorter leukocyte telomere repeat length with dementia and mortality. Arch Neurol 69, 1332–1339 3. Temple V., Jozsvai E., Konstantareas M.M., and Hewitt T.A. (2001). Alzheimer dementia in Down's syndrome: the relevance of cognitive ability. J Intellect Disabil Res 45, 47–55
  3. 4. Gruszecka A, Kopczyński P, Cudziło D, et al. Telomere shortening in Down syndrome pa-tients--when does it start? DNA and Cell Biology. 2015 Jun;34(6):412-417. DOI: 10.1089/dna.2014.2746.
  4. 5. Révész D., Milaneschi Y., Verhoeven J.E., and Penninx B.W.J.H. (2014). Telomere length as a marker of cellular ageing is associated with prevalence and progression of metabolic syndrome. J Clin Endocrinol Metab 99, 4607–4615
  5. 6. Nakamura K.I., Ishikawa N., Izumiyama N., Aida J., Kuroiwa M., Hiraishi N., et al. (2014). Telomere lengths at birth in trisomies 18 and 21 measured by Q-FISH. Gene 533, 199–207
  6. 7. Li, Chen, et al. Genome-wide Association Analysis in Humans Links Nucleotide Metabo-lism to Leukocyte Telomere Length
  7. 8. R.C. Allsopp, H. Vaziri, C. Patterson, S. Goldstein, E.V. Younglai, A.B. Futcher, C.W. Greider, C.B. Harley Telomere length predicts replicative capacity of human fibroblasts Proc. Natl. Acad. Sci. USA, 89 (1992), pp. 10114-10118
  8. 9. T. de Lange Shelterin-Mediated Telomere Protection Annu. Rev. Genet., 52 (2018), pp. 223-247

Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Review

Publication Date

March 25, 2021

Submission Date

June 22, 2020

Acceptance Date

January 31, 2021

Published in Issue

Year 2021 Volume: 11 Number: 2

APA
Bojkovic, M., & Chandra, S. (2021). The effect of Telomere Lengthening on Genetic Diseases. Journal of Contemporary Medicine, 11(2), 254-261. https://doi.org/10.16899/jcm.756562
AMA
1.Bojkovic M, Chandra S. The effect of Telomere Lengthening on Genetic Diseases. J Contemp Med. 2021;11(2):254-261. doi:10.16899/jcm.756562
Chicago
Bojkovic, Marko, and Sathees Chandra. 2021. “The Effect of Telomere Lengthening on Genetic Diseases”. Journal of Contemporary Medicine 11 (2): 254-61. https://doi.org/10.16899/jcm.756562.
EndNote
Bojkovic M, Chandra S (March 1, 2021) The effect of Telomere Lengthening on Genetic Diseases. Journal of Contemporary Medicine 11 2 254–261.
IEEE
[1]M. Bojkovic and S. Chandra, “The effect of Telomere Lengthening on Genetic Diseases”, J Contemp Med, vol. 11, no. 2, pp. 254–261, Mar. 2021, doi: 10.16899/jcm.756562.
ISNAD
Bojkovic, Marko - Chandra, Sathees. “The Effect of Telomere Lengthening on Genetic Diseases”. Journal of Contemporary Medicine 11/2 (March 1, 2021): 254-261. https://doi.org/10.16899/jcm.756562.
JAMA
1.Bojkovic M, Chandra S. The effect of Telomere Lengthening on Genetic Diseases. J Contemp Med. 2021;11:254–261.
MLA
Bojkovic, Marko, and Sathees Chandra. “The Effect of Telomere Lengthening on Genetic Diseases”. Journal of Contemporary Medicine, vol. 11, no. 2, Mar. 2021, pp. 254-61, doi:10.16899/jcm.756562.
Vancouver
1.Marko Bojkovic, Sathees Chandra. The effect of Telomere Lengthening on Genetic Diseases. J Contemp Med. 2021 Mar. 1;11(2):254-61. doi:10.16899/jcm.756562