Case Report

Methylphenidate-Induced Raynaud’s Phenomenon In Two Cases With Attention-Deficit/Hyperactivity Disorder

Volume: 11 Number: 3 May 24, 2021
EN TR

Methylphenidate-Induced Raynaud’s Phenomenon In Two Cases With Attention-Deficit/Hyperactivity Disorder

Abstract

Attention-deficit/hyperactivity disorder is a common neurodevelopmental disorder in childhood, for which there are several different treatment options. Among the suggested medications, methylphenidate (a central nervous system stimulant) is the first option in the treatment of ADHD. Psychostimulants are associated with various vascular problems including peripheral vasculopathy. This report describes two patients with ADHD who developed Raynaud's phenomenon during the modified-release methylphenidate treatment.

Keywords

References

  1. 1. Storebø OJ, Pedersen N, Ramstad E et al. Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - assessment of adverse events in non-randomised studies. Cochrane Database Syst Rev. 2018;2018(5).
  2. 2. Schiffer WK, Volkow ND, Fowler JS, Alexoff DL, Logan J, Dewey SL Therapeutic doses of amphetamine or methylphenidate differentially increase synaptic and extracellular dopamine. Synapse. 2006;59(4):243–51.
  3. 3. Jefferson HJ, Jayne DR Peripheral vasculopathy and nephropathy in association with phentermine. Nephrol Dial Transplant. 1999;14(7):1761–3.
  4. 4. Cantu C, Arauz A, Murillo Bonilla LM, López M, Barinagarrementeria F. Stroke associated with sympathomimetics contained in over-the-counter cough and cold drugs. Stroke. 2003;34(7):1667–72.
  5. 5. Prete M, Fatone MC, Favoino E, Perosa F. Raynaud’s phenomenon: From molecular pathogenesis to therapy. Autoimmun Rev [Internet]. 2014;13(6):655–67.
  6. 6. Jaffe I. Serotonin reuptake inhibitors in Raynaud’s phenomenon. Lancet. 1995;345(8961):1378.
  7. 7. Golmirzaei J, Mahboobi H, Yazdanparast M, Mushtaq G, Kamal M, Hamzei E. Psychopharmacology of Attention-Deficit Hyperactivity Disorder: Effects and Side Effects. Curr Pharm Des. 2016;22(5):590–4.
  8. 8. Faraone S V. The pharmacology of amphetamine and methylphenidate: Relevance to the neurobiology of attention-deficit/hyperactivity disorder and other psychiatric comorbidities. Neurosci Biobehav Rev. 2018;87:255–70.

Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Case Report

Publication Date

May 24, 2021

Submission Date

December 7, 2020

Acceptance Date

March 12, 2021

Published in Issue

Year 2021 Volume: 11 Number: 3

APA
Ferahkaya, H., & Akça, Ö. F. (2021). Methylphenidate-Induced Raynaud’s Phenomenon In Two Cases With Attention-Deficit/Hyperactivity Disorder. Journal of Contemporary Medicine, 11(3), 423-424. https://doi.org/10.16899/jcm.837023
AMA
1.Ferahkaya H, Akça ÖF. Methylphenidate-Induced Raynaud’s Phenomenon In Two Cases With Attention-Deficit/Hyperactivity Disorder. J Contemp Med. 2021;11(3):423-424. doi:10.16899/jcm.837023
Chicago
Ferahkaya, Hurşit, and Ömer Faruk Akça. 2021. “Methylphenidate-Induced Raynaud’s Phenomenon In Two Cases With Attention-Deficit Hyperactivity Disorder”. Journal of Contemporary Medicine 11 (3): 423-24. https://doi.org/10.16899/jcm.837023.
EndNote
Ferahkaya H, Akça ÖF (May 1, 2021) Methylphenidate-Induced Raynaud’s Phenomenon In Two Cases With Attention-Deficit/Hyperactivity Disorder. Journal of Contemporary Medicine 11 3 423–424.
IEEE
[1]H. Ferahkaya and Ö. F. Akça, “Methylphenidate-Induced Raynaud’s Phenomenon In Two Cases With Attention-Deficit/Hyperactivity Disorder”, J Contemp Med, vol. 11, no. 3, pp. 423–424, May 2021, doi: 10.16899/jcm.837023.
ISNAD
Ferahkaya, Hurşit - Akça, Ömer Faruk. “Methylphenidate-Induced Raynaud’s Phenomenon In Two Cases With Attention-Deficit Hyperactivity Disorder”. Journal of Contemporary Medicine 11/3 (May 1, 2021): 423-424. https://doi.org/10.16899/jcm.837023.
JAMA
1.Ferahkaya H, Akça ÖF. Methylphenidate-Induced Raynaud’s Phenomenon In Two Cases With Attention-Deficit/Hyperactivity Disorder. J Contemp Med. 2021;11:423–424.
MLA
Ferahkaya, Hurşit, and Ömer Faruk Akça. “Methylphenidate-Induced Raynaud’s Phenomenon In Two Cases With Attention-Deficit Hyperactivity Disorder”. Journal of Contemporary Medicine, vol. 11, no. 3, May 2021, pp. 423-4, doi:10.16899/jcm.837023.
Vancouver
1.Hurşit Ferahkaya, Ömer Faruk Akça. Methylphenidate-Induced Raynaud’s Phenomenon In Two Cases With Attention-Deficit/Hyperactivity Disorder. J Contemp Med. 2021 May 1;11(3):423-4. doi:10.16899/jcm.837023

Cited By