Hematological Findings in Children with Serum Vitamin B12 Deficiency

Abstract

Aim: Vitamin B12 is essential for DNA synthesis and hematopoiesis, and its severe deficiency not only causes anemia, but may also result in thrombocytopenia and leucopenia. In this study, we analysed the relationship between hematological status and vitamin B12 deficiency and draw attention to this issue. Material and Method: The data gathered from our institute Gaziantep University Hospital outpatient clinics electronic database. Six hundred forty children were evaluated. The inclusion criteria were child patients with less than 200 ng/l vitamin B12 levels. Results: Four hundred seventy-seven patients (74.5%) had no hematological abnormalities. Anemia was detected in 99 patients (15.5 %), two patients (0.3%) had a Hb-level < 7 g/dl, anemia without macrocytosis in 91 (14.2 %), anemia with macrocytosis in 8 (1.3 %), leucopenia in 8 (1.3 %), neutropenia in 22 (3.4 %), lymphopenia in 9 (1.4 %), thrombocytopenia in 6 (0.9 %), and pancytopenia in 3 patients (0.4 %). An examination of the correlation, there were no correlations between vitamin B12 levels and hematological parameters. Conclusion: Our results showed that hematological abnormalities were detected in only 25.5% of patients with Vitamin B12 deficiency, and anemia and neutropenia were the most common hematological abnormalities. In addition, serum vitamin B12 levels were not significantly correlated with the complete blood count parameters.

Keywords

• Vitamin B12,
• anemia,
• neutropenia

Serum Vitamin B12 Eksikliği Olan Çocuklarda Hematolojik Bulgular

Abstract

Amaç: Vitamin B12 DNA sentezi ve hematopoez için temeldir ve şiddetli eksikliği yalnızca anemiye neden olmaz aynı zamanda trombositopeni ve lökopeniye neden olabilir. Bu çalışmada, vitamin B12 eksikliği ve hematolojik durumlar arasındaki ilişkiye dikkat çekmek istedik. Gereç ve Yöntem: Bu çalışmanın verileri Gaziantep Üniversitesi ayaktan hasta poliklinikleri elektronik veri sisteminden toplanmıştır. 640 çocuk değerlendirildi. Çalışmaya vitamin B12 seviyesi 200 ng/l’den düşük çocuklar dahil edildi. Bulgular: 477 hastada (%74.5) hematolojik anormallik saptanmadı. Anemi 99 (%15,5) hastada, 2 hastada Hb seviyesi 7 gr/dl’den düşüktü, 91 (%14,2) hastada makrositozsuz anemi, 8’inde (%1,3) makrositozlu anemi, 8’inde (%1,3) lokopeni, 22’sinde (%3,4) nötropeni, 9’unda (%1,4) lenfopeni, 6’sında (%0,9) trombositopeni ve 3 (%0,4) hastada pansitopeni saptandı. Korelasyon değerlendirilmesinde vitamin B12 seviyesinin 200 ng/l’den düşük olmasıyla hematolojik parametreler arasında bir ilişki saptanmadı. Sonuç: Bizim sonuçlarımız gösterdi ki vitamin B12 eksikliği saptanan olguların yalnızca %25,5’inde hematolojik anormallik saptandı, en yaygın hematolojik anormallik ise nötropeni ve anemi idi. Vitamin B12 eksikliği olan olgularda vitamin seviyesi ile tam kan sayımı parametreleri arasında ilişki gösterilemedi.

Keywords

• anemi
• Vitamin B12
• nötropeni

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