New markers in the differentiation of Covid 19 disease and pneumonia: Neutrophil and platelet lymphocyte ratio

Abstract

Background: COVID-19; It is a pandemic disease that starts like a simple upper respiratory infection and causes pneumonia and severe respiratory failure. Due to cytokine storm and hyperinflamation, some hematological and biochemical findings appear in the disease. Complete blood count (CBC) is a very simple and inexpensive test that can be used in many infectious diseases. Methods: Eighty patients diagnosed with COVID-19 by RT-PCR were divided into two groups according to the presence of pneumonia in the Thorax CT (CT + 40 patients and CT- 40 patients). 40 healthy patients who had no previous disease were selected as the control group. The demographic and laboratory characteristics of COVID-19 patients with and without pneumonia in all three groups and control group patients were compared retrospectively. Results: While there was a significant difference between the COVID-19 group and the control group in terms of Neutrophil lymphocyte ratio (NLR) and Mean platelet volume (MPV), no differences were observed in COVID patients with and without pneumonia in terms of NLR and MPV. There was no significant difference between the COVID-19 group and the control group and the COVID pneumonia group in terms of Platelet lymphocyte ratio (PLR). Conclusion: NLR and MPV can be used as diagnostics for the diagnosis of COVID-19 disease, while PLR cannot be used. However, NLR and MPV values are not significant in evaluating COVID pneumonia and disease severity.

Keywords

• COVID-19
• SARS-CoV-2
• Pneumonia
• Neutrophil lymphocyte ratio
• Platelet lymphocyte ratio
• Mean platelet volume
• NLR
• PLR
• MPV

Covid 19 hastalığı ile pnömoninin farklılaşmasında yeni belirteçler: Nötrofil ve trombosit lenfosit oranı

Abstract

Arka plan: COVID-19; Basit bir üst solunum yolu enfeksiyonu gibi başlayıp zatürreye ve ciddi solunum yetmezliğine neden olan pandemik bir hastalıktır. Hastalıkta sitokin fırtınası ve hiperinflamasyon nedeniyle bazı hematolojik ve biyokimyasal bulgular ortaya çıkar. Tam kan sayımı (CBC), birçok bulaşıcı hastalıkta kullanılabilen çok basit ve ucuz bir testtir. Yöntemler: RT-PCR ile COVID-19 tanısı alan 80 hasta Toraks BT'de pnömoni varlığına göre iki gruba ayrıldı (CT + 40 hasta ve CT- 40 hasta). Kontrol grubu olarak daha önce hastalığı olmayan 40 sağlıklı hasta seçildi. Her üç gruptaki pnömonili ve pnömonisiz COVID-19 hastaları ile kontrol grubu hastalarının demografik ve laboratuvar özellikleri retrospektif olarak karşılaştırıldı. Bulgular: COVID-19 grubu ile kontrol grubu arasında Nötrofil lenfosit oranı (NLO) ve Ortalama trombosit hacmi (MPV) açısından anlamlı fark varken, pnömonili ve pnömonisiz COVID hastalarında NLO açısından farklılık gözlenmedi ve MPV. Platelet lenfosit oranı (PLR) açısından COVID-19 grubu ile kontrol grubu ve COVID pnömoni grubu arasında anlamlı fark yoktu. Sonuç: NLR ve MPV, COVID-19 hastalığının teşhisi için tanı olarak kullanılabilirken, PLR kullanılamaz. Bununla birlikte, NLR ve MPV değerleri COVID pnömonisi ve hastalık şiddetinin değerlendirilmesinde anlamlı değildir.

Keywords

• COVID-19
• SARS-CoV-2
• Pnömoni
• Nötrofil lenfosit oranı
• Trombosit lenfosit oranı
• NLR
• PLR
• MPV

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