Lipofilik İlaç Zehirlenmesinde Vücut Kitle İndeksinin (VKİ) Prognoza Etkisi

Abstract

Giriş: Bu çalışmanın amacı, acil servislere başvuran hastalarda vücut kitle indeksinin (VKİ) lipofilik ilaç zehirlenmesinin prognozuna etkisini araştırmaktır. Gereç ve Yöntem: Ocak 2014 - Ağustos 2016 tarihleri arasında lipofilik ilaç zehirlenmesi nedeniyle acil servise başvuran hastaların dosyaları incelendi. Demografik özellikler, alınan ilaçlar, başvuru anında şikayetler ve fizik muayene bulguları kaydedildi. Hastaların vücut kitle indeksi hesaplandı. BMI'lerine göre grup oluşturuldu ve karşılaştırıldı. Bulgular: Çalışmaya 202 hasta dahil edildi. Katılımcıların 75'i (% 37,1) 18-24,9 VKİ aralığında, 127'si (% 62,9) ≥25 idi. VKİ grupları arasında yaş, aktif yakınma, hipertansiyon, koroner arter hastalığı, psikiyatrik hastalık, atriyal fibrilasyon, atropin ihtiyacı, pralidoksim ihtiyacı (PAM), mekanik ventilasyon süresi ve yoğun bakımda kalış süresi açısından istatistiksel olarak anlamlı farklılık gözlendi ( p <0,05). Sonuç: VKİ'si yüksek hastalarda atropin ve PAM ihtiyacı, mekanik ventilasyon süresi ve yoğun bakımda kalış süresinin daha yüksek olduğu görüldü. BMI, lipofilik ilaç intoksikasyonu olan hastaların prognozu için prognostik bir faktör olarak kullanılabilir; ancak bulguyu desteklemek için daha kapsamlı çalışmalara ihtiyaç vardır.

Keywords

• lipofilik ilaçlar
• vücut kitle indeksi
• zehirlenmeler
• acil servis

Effect Of Body Mass Index (BMI) On The Prognosis In Lipophilic Drug Intoxication

Abstract

Introduction: The aim of this study was to investigate the effects of body mass index (BMI)c on the prognosis of lipophilic drug intoxication in patients who are admitted to the emergency units. Materials and Methods: The files of the patients who presented to the emergency department with lipophilic drug poisoning between January 2014 and August 2016 were reviewed. Demographic characteristics, medications taken, complaints at the time of admission, and physical examination findings were recorded. BMI of the patients were calculated. The group was created according to their BMI. These groups were compared. Results: 202 patients were included in the study. Among the participants, 75 (37,1%) were in the 18-24,9 BMI interval, and 127 (62,9%) were ≥25. A statistically significant difference was observed between BMI groups regarding age, active complaint, hypertension, coronary artery disease, psychiatric disease, atrial fibrillation, need for atropine, need for pralidoxime (PAM), duration of mechanical ventilation and duration of intensive care unit stay (p<0,05). Conclusions: The need for atropine and PAM, duration of mechanical ventilation and intensive care unit stay were observed to be higher in patients with high BMI. BMI may be used as a prognostic factor for the prognosis of patients with lipophilic drug intoxication; however, more comprehensive studies are needed to support the finding.

Keywords

• Liphophilic drug
• body mass index
• poisoning
• emergency medicine

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