Seroprevalence of HBsAg, Anti-HBs, Anti-HCV and Anti-HIV in Behçet’s Disease

Year 2021, , 690 - 693, 17.09.2021

Esma Eroğlu , Cahit Yavuz

https://doi.org/10.16899/jcm.912691

Abstract

Introduction: Behçet's disease defined by Turkish dermatologist Hulusi Behçet is an inflammatory disease of unknown etiology and characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis and skin lesions. We aimed to evaluate hepatitis B virus, hepatitis C virus and human immunodeficiency virus seroprevalence in Behçet's Disease.
Material and Method: Patients diagnosed with Behçet’s diseaseand followed up by the dermatology outpatient clinic during 12-years period between July 2008 and July 2020 were retrospectively analyzed. Demographic datas and HBsAg, anti-HBs, anti-HCV, Anti-HIV results of the patients were recorded.
Results: 359 patients with Behçet’s disease were been evaluated in this study. Of these patients, 189 (52.6%) were female, 170 (47.4%) were male and the mean age was 37.7±12.3 years. HBsAg was positive in 6 (1.6%) patients and Anti-Hbs ab in 82 (7.7%) patients. Anti HIV ab was negative in all patients. Anti-HCV antibodies were found positive in only one case (0.2%), and this was confirmed by testing for hepatitis C virus-ribonucleic acid (HCV RNA). HCV RNA was negative in this patient.
Conclusion: When compared with the general population, seropositivity rates were not detected to be high in Behçet's patients. In fact, the immunity rates were found very low. Based on such a finding, it was concluded that screening is required due to increasing immunosupressive treatments today, and individuals should be vaccinated in cases where HBV indicators are negative.In the other studies, investigating the entity, seropositivity rates have been found similar to those in the population. Considering that serological data show regional differences, we thought that, our study will contribute to the literature both national and international grades due to large patient population in our region.

Keywords

Behçet's disease, Hepatitis B virus, Hepatitis C virus, Human immunodeficiency virus

Behçet hastalığında HBsAg, Anti-HBs, Anti-HCV ve Anti-HIV seroprevalansı

Abstract

Giriş: Behçet hastalığı bir Türk dermatoloğu olan Hulusi Behçet tarafından tanımlanmış; etyolojisi bilinmeyen, tekrarlayan aftöz ülserler, genital ülserler, üveit ve deri lezyonları ile karakterli inflamatuar hastalıktır. Çlışmamızda Behçet hastalarında HBV, HCV ve HIV seroprevalansını değerlendirmeyi amaçladık.
Materyal ve Metod: Temmuz 2008 ile Temuuz 2020 tarihleri arasında dermatoloji polikliniğinde takip edilen Behçet hastalarının dosya bilgileri retrospektif olarak analiz edildi. Demografik verileri ile HBsAg, anti-HBs, anti-HCV, Anti-HIV sonuçları kaydedildi.
Sonuçlar: 189'u kadın (52.6%) ve 170'i erkek (47.4%) olmak üzere yaş ortalamaları 37.7±12.3 olan 359 Behçet hastası değerlendirildi. 6 hastada (1.6%) HBsAg pozitif olduğu görülürken, 82 hastada (7.7%) Anti-Hbs antikorunun pozitif olduğu görüldü. Anti HIV antikorunun tüm hastalarda negatif olduğu görülürken, anti-HCV antikorunun ise sadece 1 hastada pozitif olduğu görüldü (0.2%) ve sonucun HCV-RNA ile kontrol edildiği ve negatif olduğu görüldü.
Tartışma: Genel popülasyonla karşılaştırıldığında Behçet hastalarında seropozitiflik oranının yüksek olmadığı görüldü. Esasen immünite oranlarının düşük olduğu görüldü. Elde edilen sonuca göre immünsupresif tedavilerin arttığı günümüzde seroprevalans değerlendirmesinin Behçet hastalarında önemli olduğu düşünüldü. Ayrıca HBV göstergelerinin negatif olduğu hastalarda aşılama düşünülmelidir. Çalışma sonuçlarının genel olarak normal popülasyon ve diğer Behçet hastalığı ile ilgili seroprevalans çalışmalarından farklı olması ülkemizdeki ve bölgemizdeki farklılıklara bağlı olduğu düşünüldü.

Keywords

Behçet hastalığı, Hepatit B virüs, Hepatit C virüs, İnsan immünyetmezlik virüsü

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