Research Article
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Year 2021, , 728 - 733, 17.09.2021
https://doi.org/10.16899/jcm.973825

Abstract

References

  • 1- Özdemir S, Algın A. How will the Health Literacy and Crowded Emergency Room Be Affected After the COVID-19 Pandemic? Phnx Med J. 2021; 3(1): 50.
  • 2- Zhou B, Kojima S, Kawamoto A, Fukushima M. COVID-19 pathogenesis, prognostic factors, and treatment strategy: Urgent recommendations. J Med Virol. 2021 May;93(5):2694-2704. doi: 10.1002/jmv.26754. Epub 2021 Jan 11. PMID: 33368358.
  • 3- Gallo Marin B, Aghagoli G, Lavine K, et al. Predictors of COVID-19 severity: A literature review. Rev Med Virol. 2021 Jan;31(1):1-10. doi: 10.1002/rmv.2146. Epub 2020 Jul 30. PMID: 32845042; PMCID: PMC7855377.
  • 4- Ye W, Chen G, Li X, et al. Dynamic changes of D-dimer and neutrophil-lymphocyte count ratio as prognostic biomarkers in COVID-19. Respiratory Research. 2020 Jul;21(1):169. DOI: 10.1186/s12931-020-01428-7.
  • 5- Bairwa M, Kumar R, Beniwal K, Kalita D, Bahurupi Y. Hematological profile and biochemical markers of COVID-19 non-survivors: A retrospective analysis. Clin Epidemiol Glob Health. 2021;11:100770. doi:10.1016/j.cegh.2021.100770
  • 6- Seyit M, Avci E, Nar R, et al. Neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio and platelet to lymphocyte ratio to predict the severity of COVID-19. Am J Emerg Med. 2021;40:110-114. doi:10.1016/j.ajem.2020.11.058
  • 7- Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982 Apr;143(1):29-36. doi: 10.1148/radiology.143.1.7063747. PMID: 7063747.
  • 8- Özdemir S, Akça HŞ, Algın A, Altunok İ, Eroğlu SE. Effectiveness of the rapid emergency medicine score and the rapid acute physiology score in prognosticating mortality in patients presenting to the emergency department with COVID-19 symptoms. Am J Emerg Med. 2021;49:259-264. doi:10.1016/j.ajem.2021.06.020
  • 9- Pulavendran S, Rudd JM, Maram P, et al. Combination Therapy Targeting Platelet Activation and Virus Replication Protects Mice against Lethal Influenza Pneumonia. Am J Respir Cell Mol Biol. 2019 Dec;61(6):689-701. doi: 10.1165/rcmb.2018-0196OC.
  • 10- Yang X, Yang Q, Wang Y, et al. Thrombocytopenia and its association with mortality in patients with COVID-19. J Thromb Haemost. 2020 Jun;18(6):1469-1472. doi: 10.1111/jth.14848.
  • 11- Liu Y, Sun W, Guo Y, et al. Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study. Platelets. 2020;31(4):490-496. doi:10.1080/09537104.2020.1754383
  • 12- Özdemir S, Eroğlu SE, Algın A, et al. Analysis of laboratory parameters in patients with COVID-19: Experiences from a pandemic hospital. Ann Clin Anal Med 2021; Online Preprint. doi: 10.4328/ACAM.20678
  • 13- Bozan O, Çekmen B, Atiş ŞE, et al. Prognostic value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio for mortality in patients infected with SARS-CoV-2. Ukr. J. Nephrol. and Dial. 2021;2(70):19-31. doi: 10.31450/ukrjnd.2(70).2021.03
  • 14- Güçlü E, Kocayiğit H, Okan HD, et al. Effect of COVID-19 on platelet count and its indices. Rev Assoc Med Bras (1992). 2020 Aug;66(8):1122-1127. doi: 10.1590/1806-9282.66.8.1122. PMID: 32935808.
  • 15- Akoglu EU, Özdemir S, Ak R, Ozturk TC. The Discriminative Power of Inflammatory Markers in Patients with Mild-To-Moderate Acute Pancreatitis: Mean Platelet Volume, Neutrophil-Lymphocyte Ratio, Lymphocyte-Monocyte Ratio, and Neutrophil-Monocyte Product. South Clin Ist Euras. 2021; 32(2): 159-64
  • 16- Sertbaş M, Dağcı S, Kızılay V, et al. Mean Platelet Volume as an Early Predictor for The Complication of Coronavirus Disease 19. Haydarpasa Numune Med J. 2021; 61(2): 177-82.
  • 17- Ouyang SM, Zhu HQ, Xie YN, et al. Temporal changes in laboratory markers of survivors and non-survivors of adult inpatients with COVID-19. BMC Infect Dis. 2020;20:952.
  • 18- Aktaş A, Sener K, Yilmaz N, Tunc M, Yolcu S. Is mean platelet volume useful for predicting the prognosis of COVID-19 diagnosed patients? Int J Res Stud Med Health Sci 2020;7:8–11.
  • 19- Girgin R, Cinar O, Bulut E, Akduman B, Mungan NA. The role of the Platelet Mass Index (PMI) as a new prognostic factor in Fournier’s gangrene. Afri J Urol. 2018;24(3):226–232.
  • 20- Okur N, Buyuktiryaki M, Uras N, et al. Platelet mass index in very preterm infants: can it be used as a parameter for neonatal morbidities? J Matern Fetal Neonatal Med. 2016 Oct;29(19):3218-22. doi: 10.3109/14767058.2015.1121475.

Evaluation of The Predictability of Platelet Mass Index for Short-Term Mortality in Patients with COVID 19: A Retrospective Cohort Study

Year 2021, , 728 - 733, 17.09.2021
https://doi.org/10.16899/jcm.973825

Abstract

Objective
This study aimed to determine the predictability of platelet mass index (PMI) for short-term mortality in patients with COVID 19.
Material and methods
This retrospective, observational, cohort study included corrected COVID-19 patients. Demographics, clinical characteristics, biochemical and hematological parameters and the data of all-cause mortality within 30 days after admission were noted. The receiver operating characteristic curve analysis and odds ratio were performed to determine the discriminative ability of the scores.
Results
Of the 1564 patients, with mean of age of 44 ± 16 years included in the study. A total of 57 (3.6%) patients died within 30 days of emergency department presentation. There was a statistically significant difference between the survivor and non-survivor groups in terms of the platelet count, mean platelet volume (MPV) and PMI. According to the best Youden’s index, the cut-off value for the platelet count was determined as 146 (sensitivity: 91.8%, specificity: 87.2%), and the area under curve (AUC) value was 0.593 (95% confidence interval 56.7-61.9). According to the best Youden’s index, the cut-off value for the MPV was determined as 11 (sensitivity: 24.6%, specificity: 91%), and the AUC value was 0.579 (95% confidence interval 55.2-60.5). According to the best Youden’s index, the cut-off value for the PMI was determined as 1513 (sensitivity: 28.1%, specificity: 87.2%), and the AUC value was 0.555 (95% confidence interval 52.8-58.2).

Conclusion
Platelet count, MPV and PMI were not predictor of 30-day mortality in patients with confirmed COVID-19 in emergency department.

References

  • 1- Özdemir S, Algın A. How will the Health Literacy and Crowded Emergency Room Be Affected After the COVID-19 Pandemic? Phnx Med J. 2021; 3(1): 50.
  • 2- Zhou B, Kojima S, Kawamoto A, Fukushima M. COVID-19 pathogenesis, prognostic factors, and treatment strategy: Urgent recommendations. J Med Virol. 2021 May;93(5):2694-2704. doi: 10.1002/jmv.26754. Epub 2021 Jan 11. PMID: 33368358.
  • 3- Gallo Marin B, Aghagoli G, Lavine K, et al. Predictors of COVID-19 severity: A literature review. Rev Med Virol. 2021 Jan;31(1):1-10. doi: 10.1002/rmv.2146. Epub 2020 Jul 30. PMID: 32845042; PMCID: PMC7855377.
  • 4- Ye W, Chen G, Li X, et al. Dynamic changes of D-dimer and neutrophil-lymphocyte count ratio as prognostic biomarkers in COVID-19. Respiratory Research. 2020 Jul;21(1):169. DOI: 10.1186/s12931-020-01428-7.
  • 5- Bairwa M, Kumar R, Beniwal K, Kalita D, Bahurupi Y. Hematological profile and biochemical markers of COVID-19 non-survivors: A retrospective analysis. Clin Epidemiol Glob Health. 2021;11:100770. doi:10.1016/j.cegh.2021.100770
  • 6- Seyit M, Avci E, Nar R, et al. Neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio and platelet to lymphocyte ratio to predict the severity of COVID-19. Am J Emerg Med. 2021;40:110-114. doi:10.1016/j.ajem.2020.11.058
  • 7- Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982 Apr;143(1):29-36. doi: 10.1148/radiology.143.1.7063747. PMID: 7063747.
  • 8- Özdemir S, Akça HŞ, Algın A, Altunok İ, Eroğlu SE. Effectiveness of the rapid emergency medicine score and the rapid acute physiology score in prognosticating mortality in patients presenting to the emergency department with COVID-19 symptoms. Am J Emerg Med. 2021;49:259-264. doi:10.1016/j.ajem.2021.06.020
  • 9- Pulavendran S, Rudd JM, Maram P, et al. Combination Therapy Targeting Platelet Activation and Virus Replication Protects Mice against Lethal Influenza Pneumonia. Am J Respir Cell Mol Biol. 2019 Dec;61(6):689-701. doi: 10.1165/rcmb.2018-0196OC.
  • 10- Yang X, Yang Q, Wang Y, et al. Thrombocytopenia and its association with mortality in patients with COVID-19. J Thromb Haemost. 2020 Jun;18(6):1469-1472. doi: 10.1111/jth.14848.
  • 11- Liu Y, Sun W, Guo Y, et al. Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study. Platelets. 2020;31(4):490-496. doi:10.1080/09537104.2020.1754383
  • 12- Özdemir S, Eroğlu SE, Algın A, et al. Analysis of laboratory parameters in patients with COVID-19: Experiences from a pandemic hospital. Ann Clin Anal Med 2021; Online Preprint. doi: 10.4328/ACAM.20678
  • 13- Bozan O, Çekmen B, Atiş ŞE, et al. Prognostic value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio for mortality in patients infected with SARS-CoV-2. Ukr. J. Nephrol. and Dial. 2021;2(70):19-31. doi: 10.31450/ukrjnd.2(70).2021.03
  • 14- Güçlü E, Kocayiğit H, Okan HD, et al. Effect of COVID-19 on platelet count and its indices. Rev Assoc Med Bras (1992). 2020 Aug;66(8):1122-1127. doi: 10.1590/1806-9282.66.8.1122. PMID: 32935808.
  • 15- Akoglu EU, Özdemir S, Ak R, Ozturk TC. The Discriminative Power of Inflammatory Markers in Patients with Mild-To-Moderate Acute Pancreatitis: Mean Platelet Volume, Neutrophil-Lymphocyte Ratio, Lymphocyte-Monocyte Ratio, and Neutrophil-Monocyte Product. South Clin Ist Euras. 2021; 32(2): 159-64
  • 16- Sertbaş M, Dağcı S, Kızılay V, et al. Mean Platelet Volume as an Early Predictor for The Complication of Coronavirus Disease 19. Haydarpasa Numune Med J. 2021; 61(2): 177-82.
  • 17- Ouyang SM, Zhu HQ, Xie YN, et al. Temporal changes in laboratory markers of survivors and non-survivors of adult inpatients with COVID-19. BMC Infect Dis. 2020;20:952.
  • 18- Aktaş A, Sener K, Yilmaz N, Tunc M, Yolcu S. Is mean platelet volume useful for predicting the prognosis of COVID-19 diagnosed patients? Int J Res Stud Med Health Sci 2020;7:8–11.
  • 19- Girgin R, Cinar O, Bulut E, Akduman B, Mungan NA. The role of the Platelet Mass Index (PMI) as a new prognostic factor in Fournier’s gangrene. Afri J Urol. 2018;24(3):226–232.
  • 20- Okur N, Buyuktiryaki M, Uras N, et al. Platelet mass index in very preterm infants: can it be used as a parameter for neonatal morbidities? J Matern Fetal Neonatal Med. 2016 Oct;29(19):3218-22. doi: 10.3109/14767058.2015.1121475.
There are 20 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Research
Authors

Abdullah Algın 0000-0002-9016-9701

Serdar Özdemir 0000-0002-6186-6110

Publication Date September 17, 2021
Acceptance Date August 24, 2021
Published in Issue Year 2021

Cite

AMA Algın A, Özdemir S. Evaluation of The Predictability of Platelet Mass Index for Short-Term Mortality in Patients with COVID 19: A Retrospective Cohort Study. J Contemp Med. September 2021;11(5):728-733. doi:10.16899/jcm.973825

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