Multislice Computed Tomography Angiography, B-Type Natriuretic Peptide and Calcium Score in Coronary Artery Disease

Abstract

Objective: The purpose of this study is to look into the relationship between coronary artery disease evaluated with multislice computed tomography (MSCT) findings and B-type natriuretic peptide (BNP) and calcium score (CaS). Material and Method: The study included 83 patients who were administered to our center and who had asymptomatic and stable angina pectoris. Blood samples were collected for BNP testing, and the Abbott AxSYM System kit was used for measurements. Calcium scoring was performed on each of the four main coronary arteries, and the total “Agatston” score was calculated for each patient by summing up the results. MSCT angiograms were studied at the three-dimensional operating base. Results: Coronary artery disease (CAD) was found in 51 (61.4%) patients, while the coronary arteries of 32 (38.6%) patients were deemed normal. Single-vessel involvement was detected in 17 (20.5%) patients, two-vessel involvement in 18 (21.7%) patients, and three-vessel involvement in 16 (19.3%) patients. While patients with CAD had a median BNP of 33.9 (0–834), those without CAD had a median of 19.2 (0–185), which was statistically significant (p=0.011). Furthermore, there was a positive correlation between the number of vessels involved and BNP (r = 0.364, p=0.001). BNP levels were found to be significantly higher in hypertensive patients (p=0.008). The CaS and BNP median of the group with three-vessel involvement were significantly higher (p < 0.001 and p=0.007, respectively). Conclusion: As a result, high CaS and BNP levels were discovered to be a marker for the presence and severity of CAD.

Keywords

• Coronary artery disease
• B-type natriuretic peptide
• Coronary artery calcium

Angina Pektoris Hastalarında B-Tipi Natriüretik Peptit ve Kalsiyum Skoru

Abstract

 Amaç: Bu çalışmanın amacı, çok kesitli bilgisayarlı tomografi (ÇKBT) bulguları ile değerlendirilen koroner arter hastalığı ile B tipi natriüretik peptit (BNP) ve kalsiyum skoru (KaS) arasındaki ilişkiyi incelemektir.
Gereç ve Yöntem: Merkezimize başvuran asemptomatik ve stabil angina pektorisli 83 hasta çalışmaya alındı. BNP testi için kan örnekleri alındı ve ölçümler için Abbott AxSYM Sistem kiti kullanıldı. Dört ana koroner arterin her biri için kalsiyum skorlaması yapıldı ve sonuçlar toplanarak her hasta için toplam “Agatston” skoru hesaplandı. ÇKBT anjiyogramları, üç boyutlu işlem tabanında çalışıldı.
Bulgular: 51 (%61,4) hastada koroner arter hastalığı (KAH) saptanırken, 32 (%38,6) hastanın koroner arterleri normaldi. 17 hastada (%20,5) tek damar tutulumu, 18 hastada (%21,7) iki damar tutulumu, 16 hastada (%19,3) üç damar tutulumu saptandı. KAH olan hastaların medyan BNP'si 33,9 (0-834) iken, KAH olmayanların medyan değeri 19,2 (0-185) idi ve bu istatistiksel olarak anlamlıydı (p=0,011). Ayrıca tutulan damar sayısı ile BNP arasında pozitif bir korelasyon vardı (r=0,364, p=0,001). Hipertansif hastalarda BNP düzeyleri anlamlı olarak yüksek bulundu (p=0,008). Üç damar tutulumu olan grubun KaS ve BNP medyanı anlamlı olarak daha yüksekti (sırasıyla p<0,001 ve p=0,007). Çok değişkenli lojistik regresyon sonuçlarına göre BNP ve yaş KAH varlığı ile ilişkili bulunmazken CaS ilişkili bulundu.
Sonuç: CaS, KAH varlığı ile ilişkili bulundu. Yukarıda belirtilen ilişkileri doğrulamak için daha fazla çalışma yapılmalıdır. 

Keywords

• Koroner arter hastalığı
• B tipi natriüretik peptit
• Koroner arter kalsiyum

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