The relation of chronic idiopathic urticaria with Fibromyalgia, sleep disturbance and anxiety

Year 2019, Volume: 9 Issue: 2, 151 - 155, 30.06.2019

Tuba Tülay Koca , Hülya Nazik , Mehmet Kamil Mülayim , Perihan Öztürk

https://doi.org/10.16899/jcm.578711

Cited By: 1

Abstract

Aim:
Fibromyalgia syndrome (FMS) and chronic idiopathic urticaria
(CIU) are closely related due to peripheral neurogenic inflammation
(neuropeptide secretion), immune dysfunction, and somatic complaints such as fatigue,
pain, anxiety, and sleep disturbance. This study aimed to reveal the relationship
of CIU with FMS, sleep disturbance and anxiety.

Materials
and Methods: A total of 51 patients with CIU aged
18–64 years (36.2±10.4) and 45 sex- and age-matched healthy controls were
included. Urticaria activity score (UAS)
was assessed for the severity of urticaria. 
The 2010 American College of Rheumatology classification criteria were
used for FMS diagnosis. The participants were evaluated with visual analog scale (VAS), fibromyalgia impact
questionnaire (FIQ), Pittsburgh sleep quality index (PSQI), and Beck anxiety inventory
(BAI).

Results:
The presence of FMS and body mass index
(BMI) were significantly higher in the urticaria group compared with the control
group. The mean FIQ and UAS of the urticaria group were 47.0 ± 22.1 and 1.3 ±
0.9, respectively.  UAS was positively
correlated with FIQ, PSQI, BAI and VAS (rho=0.411 p=0.004; rho=0.310 p=0.034;
rho=0.419 p=0.004; rho=0.414 p=0.004; respectively).  The presence of FMS was found to be
significantly associated with high BMI (p = 0.04).

Conclusions:
The prevalence of FMS was higher in patients with CIU than control group. Also,
FMS was more severe, general pain and fatigue, sleep disturbance and anxiety
were higher in patients with high urticarial activity. 

Keywords

Anxiety disorder, fibromyalgia syndrome, sleep disturbance, urticaria

Kronik idiopatik ürtiker ile Fibromyalji, uyku bozukluğu ve anksiyete ilişkisi

Abstract

Amaç:
Fibromiyalji sendromu (FMS) ve kronik idiyopatik ürtiker (CIU), periferik
nörojenik inflamasyon (nöropeptid salınımı), immün işlev bozukluğu ve yaygın
halsizlik, ağrı, anksiyete ve uyku bozukluğu gibi somatik şikayet nedeniyle
yakından ilişkilidir. Bu çalışmada CIU ile
FMS, uyku bozukluğu ve anksiyete ilişkisini ortaya koymak amaçlandı.

Gereç ve Yöntem: Yaşları
18-64 arasında değişen (36.2 ± 10.4) CIU'lu 51 hasta ile cinsiyet ve yaşa uygun
45 sağlıklı kontrol alındı. Ürtiker aktivite skoru (UAS) ürtiker şiddeti
açısından değerlendirildi. FMS tanısı için 2010 Amerikan Romatoloji Cemiyeti
sınıflandırma kriterleri kullanılmıştır. Katılımcılar görsel analog skala
(VAS), fibromiyalji etkisi anketi (FIQ), Pittsburgh uyku kalitesi indeksi
(PSQI) ve Beck anksiyete envanteri (BAI) ile değerlendirildi.

 

Bulgular: Ürtiker
grubunda FMS ve vücut kütle indeksi (VKİ) kontrol grubuna göre anlamlı derecede
yüksekti. Ürtiker grubunun FIQ ve UAS ortalaması sırasıyla 47.0 ± 22.1 ve 1.3 ±
0.9 idi. UAS ile FIQ, PSQI, BAI ve VAS pozitif korele idi (rho=0.411 p=0.004;
rho=0.310 p=0.034; rho=0.419 p=0.004; rho=0.414 p=0.004; sırasıyla). FMS
varlığı VKİ ile anlamlı ilişkiliydi (p = 0.04).

Sonuç: FMS
prevalansı kontrol grubuna göre CIU olan hastalarda daha yüksekti. Ayrıca,
yüksek ürtikeryel aktivite gösteren kişilerde FMS daha şiddetli, genel ağrı ve
yorgunluk, uyku bozukluğu ve anksiyete daha yüksek idi. 

Keywords

Anksiyete bozukluğu, fibromyalji sendromu, uyku bozukluğu, ürtiker

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