Kolon Kanserli Hastalarda Yaşam Analizi

Year 2021, Volume: 11 Issue: 3, 374 - 379, 24.05.2021

Ayse Ulgen , Şirin Çetin , İsa Dede

https://doi.org/10.16899/jcm.902588

Abstract

Amaç: Bu çalışmanın amacı kolon kanseri (KK) tanısı almış hastaların sağkalımını etkileyen prognostik ve demografik faktörlerin risk derecesini ve önemini araştırmaktır. Gereç ve Yöntem: Mustafa Kemal Üniversitesi Onkoloji Kliniği'nde 01/2018 – 01/2021 arasında metastaz KK tanısı almış 80 hastanın tıbbi kayıtları gözden geçirilerek yapılan retrospektif bir çalışmadır. KK'ni etkileyen prognostik ve demografik faktörleri belirlemek için Cox regresyon analizi yapıldı ve genel sağkalımı (GS) tahmin etmek için Kaplan-Meier yöntemi kullanıldı. Sağkalım olasılıkları açısından değişken düzeyler arasındaki fark, log-rank testi kullanılarak araştırıldı.
Bulgular: Hastaların ortalama yaşı 56.72 ± 12.42 idi. Kolon kanseri olan hastaların medyan yaşam süresi 48.42 aydı (% 95 güven aralığı (CI) = 41.97-54.87). Cox regresyon analizi, yaş, tip 2 diabetes mellitus (DB) ve ailede KK öyküsünün GS ile anlamlı şekilde ilişkili olduğunu gösterdi (p <0.005). 50 yaşındaki KK hastaları; DB'li hastalar ve ailesinde KK öyküsü olan hastalar, sırasıyla <50 yaşındaki hastalara; DB olmayan hastalara ve ailesinde KK olmayan hastalara kıyasla yaklaşık 3 kat daha fazla risk altındaydı.
Sonuç ve Tartışma: KK'li hastaların sağkalımını etkileyen prognostik ve demografik faktörlerin etkisi değerlendirildi. Bulgularımız KK'nin yaş, DB ve aile öyküsünün KK'li hastaların sağkalımlarını tahmin etmek için kullanılabileceğini gösterdi. Sonuçlarımızın, metastatik KK teşhisi konan hastaların tedavisi için klinisyenlere rehberlik edeceğine inanıyoruz.

Keywords

Kolon kanseri, Prognostik ve Demografik faktörler, Yaşam Analizi

Survival Analysis in Colon Cancer Patients

Abstract

Introduction: The aim of this study is to investigate the degree of risk and significance of prognostic and demographic factors affecting the survival of patients diagnosed with colon cancer (CC).
Material and Method: This was a retrospective study conducted by reviweing the medical records of 80 patients diagnosed with metastatic CC at the Oncology Clinic at the Mustafa Kemal University between 01/2018 – 01/2021. Cox regression analysis was performed to determine the prognostic and demographic factors affecting the CC and Kaplan-Meier method was used to estimate the overall survival (OS). Difference between the variable levels in terms of survival probabilities was investigated using the log-rank test.
Results: The average age of the patients was 56.72 ± 12.42. The median survival time of patients with colon cancer was 48.42 months (95% confidence interval (CI) = 41.97-54.87). Cox regression analysis showed that age, incident type 2 diabetes mellitus (DB), and family history of CC were significantly associated with OS (p <0.005). Patients with CC aged 50 years; patients with DB and patients with a family history of CC were approximately 3 times more at risk compared to patients <50 years; patients without DB and patients without CC in the family, consecutively.
Discussion and Conclusion: The effect of prognostic and demographic factors affecting the survival of patients with CC was evaluated. Our findings showed that age, DB and family history of CC can be used to estimate the survial of patients with CC. We believe that our results will help guide practitioners for the treatment of patients diagnosed with metastatic CC.

Keywords

Colon Cancer, Prognostic and Demographic Factors, Survival Analysis

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