ASSOCIATION BETWEEN HYPERURICEMIA AND NON-TRADITIONAL ADIPOSITY INDICES IN PRE-MENOPAUSAL WOMEN

Year 2021, Volume: 11 Issue: 4, 577 - 581, 31.07.2021

Mehmet Ayhan İbrahim Güney , Mustafa Can , Cevdet Duran

Abstract

Aim: Hyperuricemia is a risk factor for hypertension, type 2 diabetes mellitus, dyslipidemia, metabolic syndrome, cardiovascular diseases .
Body adiposity index (BAI), lipid accumalation pruduct (LAP), cardiometabolic index (CMI) and visceral adiposity index (VAI) are non-traditional parameters used to evaluate visceral obesity. There are not enough studies on the relationship between non-traditional adiposity markers and hyperuricemia. In this study, we aimed to investigate the relationship between hyperuricemia and non-traditional adiposity markers in pre-menopausal women.
Material and Method: 86 premenopausal women were included in the study. Height, weight, waist circumference (WC) and hip circumference measurements were made, Body mass index (kg / m²) was calculated. Blood pressure was measured from both arms after 10 minutes of rest. Blood samples were taken after 12 hours of fasting.
Rusults: 43 women (%50) had hyperuricemia. In the group with hyperuricemia, traditional and non-traditional (BAI, LAP, VAI, CMI) adiposity markers were increased. A positive correlation was found between serum uric acid (UA) levels and adiposity markers. WC, LAP and CMI were found to be independent adiposity markers of serum UA.
Conclusion: In our study, we determined that WC, LAP and CMI were independent adiposity markers for serum uric acid value.

Keywords

Cardiometabolic index,, Lipid accumalation pruduct,, Visceral adiposity,, Uric acid,

Supporting Institution

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Thanks

Dear Editor, 12 / Dec /2020 We kindly request the enclosed manuscript for your consideration of publication as an orginal manuscript in JOURNAL OF CONTEMPORARY MEDICINE. The work in the attached paper entitled “Association Between Hyperuricemia And Non-traditional Adiposity Indices in Pre-Menopausal Women” has not been published previously and is not currently being assessed for publication by any journal other than Journal of Contemporary Medicine. Each author has contributed substantially to the research, preparation and production of the paper and approves of its submission to the Journal. We are looking forward to your favorable response in your early convenience. Best regards, IBRAHIM GUNEY Professor in University of Health Sciences, Konya Research and Training Hospital, Nephrology Department, 42100 MERAM, KONYA/TURKEY Phone: [phone] e-mail: [e-mail]

MENAPOZA GİRMEYEN KADINLARDA HİPERÜRİSEMİ VE GELENEKSEL OLMAYAN ADİPOZİTE BELİRTEÇLERİ ARASINDAKİ İLİŞKİ

Abstract

Amaç: Hiperürisemi hipertansiyon, tip 2 diyabet, dislipidemi, metabolik sendrom ve kardiyovasküler hastalıklar için bir risk faktörüdür.
Vücut yağ indeksi (VYI), lipit biriktirme ürünü (LBÜ), kardiyo metabolik indeks (KMI) ve viseral adipozite indeksi (VAI) viseral adipoziteyi değerlendirmek için kullanılan geleneksel olmayan parametrelerdir. Hiperürisemi ve geleneksel olmayan adipozite belirteçleri arasındaki ilişkiyi inceleyen yeterli sayıda çalışma yoktur. Biz bu çalışmada menapoza girmemiş kadınlarda hiperürisemi ve geleneksel olmayan adipozite belirteçleri arasındaki ilişkiyi incelemeyi amaçladık.
Gereç ve Yöntem: Çalışmaya 86 menapoza girmemiş kadın dahil edildi. Boy, kilo, bel çevresi (BÇ), ve kalça çevresi ölçümleri yapıldı. VKI (kg / m²) hesaplandı. Kan basıncı 10 dakikalık dinlenmeden sonra her iki koldan ölçüldü. Kan örnekleri 12 saatlik açlıktan alındı.
Bulgular: 43 kadında (% 50) hiperürisemi tespit edildi. Hiperürisemi grubunda, geleneksel ve geleneksekl olmayan ( VYI, LBÜ, VAI, KMI) adipozite belirteçleri artmış olarak bulundu. Serum ürik asid ve adipozite belirteçleri arasında pozitif korelasyon tespit edildi. BÇ, LBÜ ve KMI serum ürik asidin bağımsız adipozite belirteçleri olarak bulundu.
Sonuç: Çalışmamızda, BÇ, LBÜ ve KMI in serum ürik asid için bağımsız adipozite belirteçleri olduğunu belirledik.

Keywords

Kardiyo metabolik indeks,, Lipid biriktirme ürünü,, Viseral adipozite,, Ürik asit,

References

• REFERENCES 1. Grayson PC, Kim SY, LaValley M, Choi HK. Hyperuricemia and incident hypertension: a systematic review and metaanalysis. Arthritis Care Res (Hoboken) 2011;63:102–10.
• REFERENCES 1. Grayson PC, Kim SY, LaValley M, Choi HK. Hyperuricemia and incident hypertension: a systematic review and metaanalysis. Arthritis Care Res (Hoboken) 2011;63:102–10.
• 2. Lv Q, Meng XF, He FF, et al. High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies. PloS One 2013;8:e56864.
• 2. Lv Q, Meng XF, He FF, et al. High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies. PloS One 2013;8:e56864.
• 3. Zhang Q, Zhang C, Song X, et al. A longitudinal cohort–based association study between uric acid level and metabolic syndrome in Chinese Han urban male population. BMC Public Health. 2012;12:419.
• 3. Zhang Q, Zhang C, Song X, et al. A longitudinal cohort–based association study between uric acid level and metabolic syndrome in Chinese Han urban male population. BMC Public Health. 2012;12:419.
• 4. Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Albert DA. Hyperuricemia and coronary heart disease: a systematic review and meta-analysis. Arthritis Care Res (Hoboken) 2010;62:170–80.
• 4. Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Albert DA. Hyperuricemia and coronary heart disease: a systematic review and meta-analysis. Arthritis Care Res (Hoboken) 2010;62:170–80.
• 5. Chen JH, Chuang SY, Chen HJ, Yeh WT, Pan WH. Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study. Arthritis and rheumatism. 2009; 61:225–32.
• 5. Chen JH, Chuang SY, Chen HJ, Yeh WT, Pan WH. Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study. Arthritis and rheumatism. 2009; 61:225–32.
• 6. Sautin YY, Nakagawa T, Zharikov S, Johnson RJ. Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol-Cell Ph. 2007; 293:C584–96.
• 6. Sautin YY, Nakagawa T, Zharikov S, Johnson RJ. Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol-Cell Ph. 2007; 293:C584–96.
• 7. Corry DB, Eslami P, Yamamoto K, Nyby MD, Makino H, Tuck ML. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stressvia the vascular renin-angiotensin system. Journal of hypertension. 2008; 26:269–75.
• 7. Corry DB, Eslami P, Yamamoto K, Nyby MD, Makino H, Tuck ML. Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stressvia the vascular renin-angiotensin system. Journal of hypertension. 2008; 26:269–75.
• 8. Pouliot MC, Despres JP, Lemieux S, et al. Waist circumference and abdominal saggital diameter: best simple anthropometric indices of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men andwomen. Am J Cardiol. 1994,73:460-68.
• 8. Pouliot MC, Despres JP, Lemieux S, et al. Waist circumference and abdominal saggital diameter: best simple anthropometric indices of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men andwomen. Am J Cardiol. 1994,73:460-68.
• 9. Rader DJ. Effect of insulin resistance, dyslipidemia, and intra-abdominal adiposity on the development of cardiovascular disease and diabetes mellitus. Am J Med. 2007;120(Suppl. 1):S12–S18.
• 9. Rader DJ. Effect of insulin resistance, dyslipidemia, and intra-abdominal adiposity on the development of cardiovascular disease and diabetes mellitus. Am J Med. 2007;120(Suppl. 1):S12–S18.
• 10. Liu XZ, Li HH, Huang S, Zhao DB. Association Between Hyperuricemia and Nontraditional Adiposity Indices. Clin Rheumatol. 2019 Apr;38(4):1055-62.
• 10. Liu XZ, Li HH, Huang S, Zhao DB. Association Between Hyperuricemia and Nontraditional Adiposity Indices. Clin Rheumatol. 2019 Apr;38(4):1055-62.
• 11. dos Santos RE, Aldrighi JM, Lanz JR, Ferezin PC, Marone MMS.. Relationship of body fat distribution by waist circumference, dual energy X-ray absorptiometry and ultrasonography to insulin resistance by homeostasis model assessment and lipid profile in obese and non-obese postmenopausal women. Gynecol Endocrinol. 2005. 21(5): p. 295-301.
• 11. dos Santos RE, Aldrighi JM, Lanz JR, Ferezin PC, Marone MMS.. Relationship of body fat distribution by waist circumference, dual energy X-ray absorptiometry and ultrasonography to insulin resistance by homeostasis model assessment and lipid profile in obese and non-obese postmenopausal women. Gynecol Endocrinol. 2005. 21(5): p. 295-301.
• 12. Borruel S, Moltó JF, Alpañés M, et al. Surrogate markers of visceral adiposity in young adults: waist circumference and body mass index are more accurate than waist hip ratio, model of adipose distribution and visceral adiposity index. PloS One. 2014; 9(12): e114112.
• 12. Borruel S, Moltó JF, Alpañés M, et al. Surrogate markers of visceral adiposity in young adults: waist circumference and body mass index are more accurate than waist hip ratio, model of adipose distribution and visceral adiposity index. PloS One. 2014; 9(12): e114112.
• 13. Amato MC, Giordano C, Galia M, et al. Visceral Adiposity Index: a reliable indicator of visceral fat function associated with cardiometabolic risk. Diabetes Care. 2010,33:920-22.
• 13. Amato MC, Giordano C, Galia M, et al. Visceral Adiposity Index: a reliable indicator of visceral fat function associated with cardiometabolic risk. Diabetes Care. 2010,33:920-22.
• 14. Ishizaka N, Ishizaka Y, Toda A, et al. Changes in waist circumference and body mass index in relation to changes in serum uric acid in Japanese individuals. J Rheumatol.2010. 37(2):410–16.
• 14. Ishizaka N, Ishizaka Y, Toda A, et al. Changes in waist circumference and body mass index in relation to changes in serum uric acid in Japanese individuals. J Rheumatol.2010. 37(2):410–16.
• 15. Suma S, Naito M, Okada R, et al. associations between body mass index and serum uric acid levels in a japanese population were significantly modified by LRP2 rs2544390. Nagoya J Med Sci. 2014. 76(3–4):333–39
• 15. Suma S, Naito M, Okada R, et al. associations between body mass index and serum uric acid levels in a japanese population were significantly modified by LRP2 rs2544390. Nagoya J Med Sci. 2014. 76(3–4):333–39
• 16. Chen JH, Pan WH, Hsu CC, et al. Impact of obesity and hypertriglyceridemia on gout development with or without hyperuricemia: a prospective study. Arthritis Care Res (Hoboken). 2013. 65(1):133–40.
• 16. Chen JH, Pan WH, Hsu CC, et al. Impact of obesity and hypertriglyceridemia on gout development with or without hyperuricemia: a prospective study. Arthritis Care Res (Hoboken). 2013. 65(1):133–40.
• 17. You L, Liu A, Wuyun G, Wu H, Wang P. Prevalence of hyperuricemia and the relationship between serum uric acid and metabolic syndrome in the Asian Mongolian area. J Atheroscler Thromb. 2014. 21(4):355–65
• 17. You L, Liu A, Wuyun G, Wu H, Wang P. Prevalence of hyperuricemia and the relationship between serum uric acid and metabolic syndrome in the Asian Mongolian area. J Atheroscler Thromb. 2014. 21(4):355–65
• 18. Huang X, Jiang X, Wang L, et al. Visceral Adipose Accumulation Increased the Risk of Hyperuricemia Among Middle-Aged and Elderly Adults: A Population-Based Study. J Transl Med. 2019. Oct 10;17(1):341-50.
• 18. Huang X, Jiang X, Wang L, et al. Visceral Adipose Accumulation Increased the Risk of Hyperuricemia Among Middle-Aged and Elderly Adults: A Population-Based Study. J Transl Med. 2019. Oct 10;17(1):341-50.
• 19. Wang H, Sun Y, Wang S, et al. Body Adiposity Index, Lipid Accumulation Product, and Cardiometabolic Index Reveal the Contribution of Adiposity Phenotypes in the Risk of Hyperuricemia Among Chinese Rural Population. Clin Rheumatol. 2018 Aug; 37 (8): 2221-31.
• 19. Wang H, Sun Y, Wang S, et al. Body Adiposity Index, Lipid Accumulation Product, and Cardiometabolic Index Reveal the Contribution of Adiposity Phenotypes in the Risk of Hyperuricemia Among Chinese Rural Population. Clin Rheumatol. 2018 Aug; 37 (8): 2221-31.
• 20. Dong H , Xu Y , Zhang Y, Tian S. Visceral Adiposity Index Is Strongly Associated With Hyperuricemia Independently of Metabolic Health and Obesity Phenotypes. Sci Rep. 2017 Aug 18;7(1):8822.
• 20. Dong H , Xu Y , Zhang Y, Tian S. Visceral Adiposity Index Is Strongly Associated With Hyperuricemia Independently of Metabolic Health and Obesity Phenotypes. Sci Rep. 2017 Aug 18;7(1):8822.
• 21. Gu D, Ding Y, Zhao Y, Miao S, Qu Q. Positively Increased Visceral Adiposity Index in Hyperuricemia Free of Metabolic Syndrome. Lipids Health Dis. 2018 May 7;17(1):101-7.
• 21. Gu D, Ding Y, Zhao Y, Miao S, Qu Q. Positively Increased Visceral Adiposity Index in Hyperuricemia Free of Metabolic Syndrome. Lipids Health Dis. 2018 May 7;17(1):101-7.
• 22. Yamada A, Sato KK, Kinuhata S, et al. Association of Visceral Fat and Liver Fat With Hyperuricemia. T.Arthritis Care Res (Hoboken). 2016 Apr;68(4):553-61.
• 22. Yamada A, Sato KK, Kinuhata S, et al. Association of Visceral Fat and Liver Fat With Hyperuricemia. T.Arthritis Care Res (Hoboken). 2016 Apr;68(4):553-61.
• 23. Ibrahim MM. Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev. 2010 Jan;11(1):11-18.
• 23. Ibrahim MM. Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev. 2010 Jan;11(1):11-18.
• 24. Takir M. Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia. J Investig Med. 2015 Dec;63(8):924-29.
• 24. Takir M. Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia. J Investig Med. 2015 Dec;63(8):924-29.