Comparison of the Effects of Different Molecular Weight Hyaluronic Acid Application in Knee Osteoarthritis

Year 2022, Volume: 12 Issue: 6, 973 - 977, 30.11.2022

Ali Çoştu

https://doi.org/10.16899/jcm.1123734

Abstract

Objective: The objective of this study was to evaluate the effect of different molecular weight (MW) hyaluronic acid (HA) application on pain and functional parameters in knee osteoarthritis (OA).
Methods: This study was designed as retrospectively. Hospital records of the patients who received intraarticular HA injection therapy in our center were screened. The patients were divided into 3 categories according to the MW of the preparates as the follows; Group 1: 0,6-1,2 Milion Da of MW (N=26); Group 2: 1,1- 2,2 Million Da of MW (N=25); and Group 3: 1,7-2,1 Million Da of MW (N=25). All patients were assessed using Visual Analogue Scale (VAS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) before the treatment and one month after the injection.
Results: A total of 76 patients (61 females, 15 males) with a mean age of 62,1 years (minimum-maximum: 50-70 years) were included. VAS and WOMAC scores did improve significantly in all groups (all for p<0.001). However, no significant difference was observed between the groups in terms of the delta values of the VAS and WOMAC scores between the groups (p: 0,721 and p: 0,595, respectively).
Conclusion: In conclusion, significant reductions in VAS and WOMAC scores were observed in all 3 patient groups in our study. Yet, there was no significant difference regarding the MW of HA preparations.

Keywords

knee osteoarthritis, hyaluronic acid, pain

Project Number

2017-610

Diz Osteoartritinde Farklı Molekül Ağırlıklı Hyaluronik Asit Uygulamalarının Etkilerinin Karşılaştırılması

Abstract

Amaç: Bu çalışmanın amacı, diz osteoartritinde (OA) farklı moleküler ağırlıklı (MA) hyaluronik asit (HA) uygulamasının ağrı ve fonksiyonel parametreler üzerindeki etkisini değerlendirmektir.
Yöntemler: Bu çalışma geriye dönük olarak planlandı. Merkezimizde intraartiküler HA enjeksiyon tedavisi alan hastaların hastane kayıtları tarandı. Preparatların MA'sına göre hastalar aşağıdaki gibi 3 kategoriye ayrıldı; Grup 1: 0,6-1,2 Milyon Da MA (N=26); Grup 2: 1,1- 2,2 Milyon Da MA (N=25); ve Grup 3: 1,7-2,1 Milyon Da MA (N=25). Tüm hastalar, tedaviden önce ve enjeksiyondan bir ay sonra Görsel Analog Skala (VAS) ve Western Ontario ve McMaster Universities Arthritis Index (WOMAC) kullanılarak değerlendirildi.
Bulgular: Yaş ortalaması 62,1 yıl (minimum-maksimum: 50-70 yıl) olan toplam 76 hasta (61 kadın, 15 erkek) dahil edildi. VAS ve WOMAC skorları tüm gruplarda anlamlı olarak iyileşti (tümü için p<0,001). Ancak gruplar arasında VAS ve WOMAC puanlarının delta değerleri açısından gruplar arasında anlamlı bir fark gözlenmedi (sırasıyla p: 0,721 ve p: 0,595).
Sonuç: Sonuç olarak, çalışmamızda her 3 hasta grubunda da VAS ve WOMAC skorlarında anlamlı düşüşler gözlendi. Ancak, HA preparatlarının MA'sı ile ilgili önemli bir fark yoktu.

Keywords

Diz Osteoartriti, Hyaluronik Asit, Ağrı

Supporting Institution

Hacettepe Üniversitesi Tıp Fakültesi

Project Number

2017-610

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