Results of Adjuvant Radiotherapy Based on Sedlis Criteria in Early Stage Cervical Cancer

Year 2023, Volume: 13 Issue: 3, 439 - 443, 31.05.2023

Necla Gürdal , Özge Kandemir Gürsel

https://doi.org/10.16899/jcm.1241809

Abstract

Background/Aims:
Investigation of the efficacy of adjuvant RT in cervical cancer stage I-IIA according to FIGO (2018) in terms of risk factors and oncologic outcomes.
Methods:
The study included 113 patients with FIGO stage I-IIA. Patients who received adjuvant external pelvic RT and/or intracavitary brachytherapy (ICBT) after surgery retrospectively analyzed for demographic data , histology, grade, tumor size , stage, LVSI, stromal invasion depth, type of lymphadenectomy, number of dissected pelvic / paraaortic lymph nodes , surgical margin, adjuvant therapies, local relapse, distant failure, overall survival, and progression-free survival.
Results:
After a median follow-up of 160 months, local recurrence was observed in 3 patients, distant metastasis in 6 patients and all-cause death in 15 patients. It was observed that only SID had a statistically significant effect on overall survival among the Sedlis criteria (p=0.04). The ten-year DFS and OS rates were 95% and 94%, respectively .
Conclusions:
Promising oncological results were obtained in early stage cervical cancer with adjuvant RT based on Sedlis criteria.

Keywords

Radiotherapy, Sedlis criteria, Cervix cancer

Supporting Institution

none

Project Number

none

Thanks

none

Erken Evre Serviks Kanserinde Sedlis Kriterleri Gözönünde Bulundurularak Uygulanan Adjuvant Radyoterapi Sonuçları

Abstract

ÖZ:
Amaç:
FIGO (2018) Evre I-IIA serviks kanserinde adjuvan RT ‘nin risk faktörleri ve onkolojik sonuçlar açısından etkinliğinin araştırılmasıdır.
Metod:
FIGO evre I-IIA olan 113 hasta çalışmaya dahil edilmiştir. Cerrahi sonrası adjuvan eksternal pelvik RT ve / ve ya intrakaviter brakiterapi (ICBT ) uygulanan hastalar demografik veriler, histoloji, grade, tümör boyutu , evre, LVSI, stromal invazyon derinliği (SID), lenfadenektomi tipi, diseke edilen pelvik/paraaortik lenf nodu sayısı , cerrahi sınır durumu, uygulanan adjuvant tedaviler, lokal relaps, uzak hastalık, genel sağkalım (OS), and hastalıksız sağkalım (DFS) açısından retrospektif olarak incelenmiştir.
Bulgular:
Medyan 160 aylık takip sonunda 3 hastada lokal nüks, 6 hastada uzak metastaz, 15 hastada tüm nedenlere bağlı ölüm gözlenmiştir. Sedlid kriterleri içerisinde sadece SID ‘ın OS üzerinde istatistiksel anlamlı olarak etkili olduğu gözlenmiştir. (p=0.04). On yıllık DFS ve OS oranı sırasıyla 95% ve 94% olarak bulunmuştur.
Sonuç:
Erken evre serviks kanserinde Sedlis kriterlerine dayalı adjuvan RT ile yüz güldürücü onkolojik sonuçlar elde edilmiştir.

Keywords

Radiotherapy, Sedlis criteria, Cervix cancer

Project Number

none

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