Evaluation of urine cotinine levels in children with chronic cough

Year 2023, Volume: 13 Issue: 4, 686 - 691, 31.07.2023

Yesim Özdemir Atikel , İlknur Bostancı , Çiğdem Özdilekcan , Serap Özmen

https://doi.org/10.16899/jcm.1191361

Abstract

Bacground: Our study was planned to reveal the objective relation between urine cotinine level and tobacco smoke exposure in children suffering from chronic cough.
Methods: Between ages 5-18 years, 58 patients with chronic cough with no underlying specific cause and 54 healthy individuals were included in the study.
Results: There was a statistically significant difference between urine cotinine levels of cases those who exposed and unexposed (based on the declaration of parents) to tobacco smoke (p<0, 05). The highest mean value of cotinine (41.3±73.7) was detected in the cases of chronic cough group who exposed to smoke. The best “cut-off value” for discriminating exposed and unexposed group was found to be 12.15 ng/ml with ROC analysis. Smoking ratio during pregnancy has been found higher in the group with chronic cough (p<0, 05).FEV1/FVC ratio was found to be lower in patients with chronic cough who are passive smokers when compared with the cases in the other groups (p<0,05).
Conclusions: This is the first study objectively evaluating chronic cough effect of passive smoking with urine cotinine level. Since there is a meaningful decrease in FEV1/FVC ratio, close follow up is needed especially in children diagnosed as chronic cough who are exposed to tobacco smoke.

Keywords

biomarkers, children, chronic cough, environmental tobacco smoke, passive smoking, urine cotinine level

Kronik öksürüklü çocukların idrar kotinin düzeyleri ile değerlendirilmesi

Abstract

Giriş ve amaç: Çalışmamız kronik öksürüklü çocuklarda idrar kotinin düzeyi ile sigara dumanı maruziyetini objektif olarak göstermek için planlandı.
Gereç ve Yöntem: 5-18 yaş arası, kronik öksürüğü olan 58 ve sağlıklı 54 olmak üzere 112 çocuk çalışmaya dahil edildi.
Bulgular: Ebeveyn beyanına göre sigara dumanına maruz kalan ve kalmayan olguların idrar kotinin düzeyleri arasında istatistiksel olarak anlamlı fark vardı (p<0, 05). En yüksek ortalama kotinin düzeyi (41.3±73.7) kronik öksürüğü olup sigaraya maruz kalan grupta saptandı. Sigara dumanına maruz kalan ve kalmayan grupları ayırt etmek için en iyi “cut-off” değeri (kesim noktası) ROC analizi ile 12.15 ng/ml olarak bulundu. Gebelikte sigara içme oranı kronik öksürüğü olan ve sigara dumanına maruz kalan grupta daha yüksek bulundu (p<0, 05). Pasif içici olan kronik öksürüğü olan çocuklarda FEV1/FVC oranı diğer gruplara göre daha düşük bulundu ( p<0,05).
Sonuç: Bu, pasif içiciliğin çocuklarda kronik öksürük üzerine etkisini idrar kotinin düzeyi ile objektif olarak değerlendiren ilk çalışmadır. FEV1/FVC oranında anlamlı düşme nedeniyle tütün dumanına maruz kalan kronik öksürüklü çocuklarda yakın takip gereklidir.

Keywords

biyobelirteçler, çevresel tütün dumanı, çocuk, kronik öksürük, pasif içicilik, idrar kotinin düzeyi

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