Clinical Research
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TÜRKİYE'DEKİ BİR 3. BASAMAK HASTANEDE, DÖRT ENFEKSİYON DALGASI SIRASINDA COVID-19 OLAN 333 GEBE KADININ ÖZELLİKLERİ, KLİNİK BULGULARI VE SONUÇLARI

Year 2023, Volume: 13 Issue: 4, 625 - 631, 31.07.2023
https://doi.org/10.16899/jcm.1280728

Abstract

Amaç:
Türkiye'de ilk SARS-CoV-2 vakasından bu yana, 14 milyondan fazla insanda doğrulandı ve yaklaşık 95.000 ölüme neden oldu. SARS-CoV-2 pandemisinin iki yıllık seyri boyunca Türkiye'de 4 hastalık dalgasına neden oldu.
Dört farklı pandemi dalgası sırasında COVID-19 enfeksiyonunun ilk sunumu, klinik seyri ve şiddeti, risk faktörleri ve gebelik sonuçları hakkındaki bilgilerimizi geliştirmek.
Gereç ve Yöntem:
Doğrulanmış pozitif PCR testi olan 333 hamile kadının klinik kayıtları incelendi. Pandeminin iki yıllık seyri boyunca hastaların dağılımı incelendi. Anne yaşı, vücut kitle indeksi (VKİ), eğitim, çalışma durumu, ABO kan grubu, önceki obstetrik öyküsü, önceki tıbbi öyküsü, sigara içme durumu ile ilgili tanımlayıcı veriler toplandı. Maternal ve acil perinatal sonuçlar incelendi. Çalışmanın birincil son noktası, pandemi sırasındaki dört dalganın YBÜ'ye kabul, mekanik ventilasyon kullanımı veya anne ve yenidoğan ölümü açısından karşılaştırılmasıydı.
Bulgular:
Hasta sayısının dağılımı, hamileleri etkilemediği görülen birinci dalga dışında, Türkiye'deki genel popülasyonla aynı modeli izlemiştir. Hastaların çoğu ve anne ölümlerinin tamamı ikinci ve dördüncü dalgalarda toplanmıştır. Daha şiddetli hastalığı olanlar daha ileri yaşta kadınlar, gebeliğin daha erken aylarında ve daha yüksek VKİ'ne sahipti.
Tartışma:
COVID-19 hastalığının şiddeti, anne yaşı ve gebelik yaşı ile güçlü bir şekilde ilişkiliydi. Türkiye'de en kötü maternal sonuçlar, hastalığın ikinci ve dördüncü dalgalarında görüldü.

Supporting Institution

YOK

Project Number

YOK

Thanks

Çalışmamızı incelemeyi kabul ettiğiniz için teşekkür ederiz.

References

  • 1. WHO COVID-19 Dashboard. Geneva: World Health Organization 2020. Available online: https://covid19.who.int/ (last cited: March 3, 2022. https://covid19.who.int/.
  • 2. https://covid19.saglik.gov.tr/.
  • 3. Kelly JC, Raghuraman N, Carter EB, Palanisamy A, Stout MJ. Preprocedural asymptomatic coronavirus disease 2019 cases in obstetrical and surgical units. AJOG. 2021;224(1):114-116.
  • 4. Jamieson DJ, Rasmussen SA. An update on COVID-19 and pregnancy. AJOG. 2022;226(2):177-186.
  • 5. Vega M, Hughes F, Bernstein PS, et al. From the trenches: inpatient management of coronavirus disease 2019 in pregnancy. AJOG MFM. 2020;2(3):100154.
  • 6. National Institutes of Health. Coronavirus disease 2019 (COVID-19) treatment guidelines. Accessed March 3, 2022. Accessed March 3, 2022. https://www.covid19treatmentguidelines.nih.gov/overview/clinical-spectrum/
  • 7. Committee on Practice Bulletins-Obstetrics. Practice Bulletin No. 183: Postpartum Hemorrhage. Obstet Gynecol. 2017;130(4):e168-e186.
  • 8. https://www.kanver.org/EKutuphane/GruplamaLaboratuari. Turk Kızılayı. Accessed March 28, 2022. https://www.kanver.org/EKutuphane/GruplamaLaboratuari
  • 9. Metz TD, Clifton RG, Hughes BL, et al. Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19). Obstet Gynecol. 2021;137(4):571-580.
  • 10. Emeruwa UN, Ona S, Shaman JL, et al. Associations Between Built Environment, Neighborhood Socioeconomic Status, and SARS-CoV-2 Infection Among Pregnant Women in New York City. JAMA. 2020;324(4):390.
  • 11. Khoury R, Bernstein PS, Debolt C, et al. Characteristics and Outcomes of 241 Births to Women With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection at Five New York City Medical Centers. Obstet Gynecol. 2020;136(2):273-282.

CHARACTERISTICS, CLINICAL FINDINGS AND OUTCOMES OF 333 PREGNANT WOMEN WITH COVID-19 DURING FOUR WAVES OF INFECTION AT A TERTIARY HOSPITAL IN TURKEY

Year 2023, Volume: 13 Issue: 4, 625 - 631, 31.07.2023
https://doi.org/10.16899/jcm.1280728

Abstract

Background/Aims:
Since the first case of SARS-CoV-2 in Turkey, it was confirmed in over 14 million people causing almost 95,000 of deaths. During the two years course of pandemic SARS-CoV-2 caused 4 waves of disease in Turkey.
To enhance our knowledge on initial presentation, clinical course and severity, risk factors, and pregnancy outcomes of COVID-19 infection during the four different waves of pandemic.
Methods:
Clinical records of 333 pregnant women with a verified positive PCR test was reviewed. The distribution of the patients during the two-year course of the pandemic was studied. Descriptive data regarding maternal age, body mass index (BMI), education, employment status, ABO blood type, previous obstetric history, previous medical history, smoking status were collected. Maternal and immediate perinatal outcomes were examined. The primary endpoint of the study was comparison of four waves during the pandemic in terms of admission to ICU, use of mechanical ventilation or maternal and neonatal death.
Results:
The distribution of number of the patients followed the same pattern as the general population in Turkey, except first wave, which did not seem to affect pregnants. Most of the patients and all the maternal deaths were accumulated in the second and fourth waves. Those with more severe disease were older, at an earlier gestational age, and had a higher BMI.
Conclusion:
The severity of the COVID-19 disease was strongly associated with the maternal age and gestational age. The worst maternal outcomes of the disease were detected during the second and fourth waves in Turkey.

Project Number

YOK

References

  • 1. WHO COVID-19 Dashboard. Geneva: World Health Organization 2020. Available online: https://covid19.who.int/ (last cited: March 3, 2022. https://covid19.who.int/.
  • 2. https://covid19.saglik.gov.tr/.
  • 3. Kelly JC, Raghuraman N, Carter EB, Palanisamy A, Stout MJ. Preprocedural asymptomatic coronavirus disease 2019 cases in obstetrical and surgical units. AJOG. 2021;224(1):114-116.
  • 4. Jamieson DJ, Rasmussen SA. An update on COVID-19 and pregnancy. AJOG. 2022;226(2):177-186.
  • 5. Vega M, Hughes F, Bernstein PS, et al. From the trenches: inpatient management of coronavirus disease 2019 in pregnancy. AJOG MFM. 2020;2(3):100154.
  • 6. National Institutes of Health. Coronavirus disease 2019 (COVID-19) treatment guidelines. Accessed March 3, 2022. Accessed March 3, 2022. https://www.covid19treatmentguidelines.nih.gov/overview/clinical-spectrum/
  • 7. Committee on Practice Bulletins-Obstetrics. Practice Bulletin No. 183: Postpartum Hemorrhage. Obstet Gynecol. 2017;130(4):e168-e186.
  • 8. https://www.kanver.org/EKutuphane/GruplamaLaboratuari. Turk Kızılayı. Accessed March 28, 2022. https://www.kanver.org/EKutuphane/GruplamaLaboratuari
  • 9. Metz TD, Clifton RG, Hughes BL, et al. Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19). Obstet Gynecol. 2021;137(4):571-580.
  • 10. Emeruwa UN, Ona S, Shaman JL, et al. Associations Between Built Environment, Neighborhood Socioeconomic Status, and SARS-CoV-2 Infection Among Pregnant Women in New York City. JAMA. 2020;324(4):390.
  • 11. Khoury R, Bernstein PS, Debolt C, et al. Characteristics and Outcomes of 241 Births to Women With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection at Five New York City Medical Centers. Obstet Gynecol. 2020;136(2):273-282.
There are 11 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Research
Authors

Elif Ünlügedik Sayın 0000-0002-6238-0446

Medine Kahraman Kaya 0000-0002-5900-5338

Elif Gundogdu 0000-0003-2961-3831

Ahmet Kale 0000-0002-1194-6649

Project Number YOK
Early Pub Date July 27, 2023
Publication Date July 31, 2023
Acceptance Date July 16, 2023
Published in Issue Year 2023 Volume: 13 Issue: 4

Cite

AMA Ünlügedik Sayın E, Kahraman Kaya M, Gundogdu E, Kale A. CHARACTERISTICS, CLINICAL FINDINGS AND OUTCOMES OF 333 PREGNANT WOMEN WITH COVID-19 DURING FOUR WAVES OF INFECTION AT A TERTIARY HOSPITAL IN TURKEY. J Contemp Med. July 2023;13(4):625-631. doi:10.16899/jcm.1280728