Acil polikliniğine başvuran ve hospitalize edilen hiperemezis gravidarum tanılı hastaların inflamasyon skorlarının normal seyirli gebelerle karşılaştırılması

Year 2024, Volume: 14 Issue: 5, 240 - 244, 25.09.2024

Özlem Dülger , Hatice Şeyma Akça

Abstract

Amaç
HEG tanılı hastalarda sistemik inflamatuar belirteçlerin (NLR(nötrofil/lenfosit oranı) , PLR (platelet/lenfosit oranı), MLR(monosit/lenfosit oranı), SII( sistemik immun-inflamasyon indeksi), ve SIRI (sistemik inflamasyon cevap indeksi), normal gebelerle, ilk trimesterde karşılaştırılması amaçlandı.
Gereç ve Yöntem
Çalışmaya, 7-12. gebelik haftaları arasında acil kadın doğum kliniğine başvuran ve 2+ ketonüri nedeniyle hospitalize edilen 52 gebe kadın dahil edildi. Kontrol grubu ise aynı gebelik haftasında olan, kadın doğum polikliniğine başvuran sağlıklı gebelerden oluşturuldu. İstatistiksel analiz SPSS (Statistical package for Social Sciences-SPSS Inc., version 20.0;Chicago, IL) programı ile yapıldı.
Bulgular
Maternal yaş, parite, vücut kitle indeksi (BMI) ve elektif küretaj sayıları açısından gruplar arasında istatistiksel olarak anlamlı fark yoktu (p>0,05). İki grup arasında trombosit, monosit, lökosit ve lenfosit değerleri karşılaştırıldığında fark bulunmadı(p>0,05). Ancak, nötrofil sayısı, NLR ve PLR sonuçları değerlendirildiğinde istatistiksel olarak anlamlı bir fark gözlemledik (p>0,05). Ayrıca, SII ve SIRI'yı içeren kombine inflamatuar indekslerin de HEG grubunda anlamlı derecede yüksek olduğunu tespit ettik (sırasıyla, p=0,000 ve p=0,0011).
Sonuç
Çalışmamızın sonuçları, nötrofil ve kombine sistemik inflamatuar indekslerinin (NLR, PLR, SII, SIRI) HEG varlığı ile ilişkili olduğunu gösterdi. Sonuçlarımıza göre, NLR'nin HEG varlığını tespit etmede en güçlü tanısal etkinliğe sahip olduğu belirlendi.

Keywords

kombine sistemik inflamatuar indeksler, hiperemezis gravidarum, gebelik

Comparison of inflammation scores of patients diagnosed with hyperemesis gravidarum who applied to the emergency clinic and were hospitalized with pregnant women with a normal course.

Abstract

Aim
We aimed to compare systemic inflammatory markers ((NLR (neutrophil/lymphocyte ratio), PLR (platelet/lymphocyte ratio), MLR( monocyte/lymphocyte ratio), SII (systemic immune-inflammation index) and SIRI (systemic inflammation response index)) in patients diagnosed with HEG with normal pregnant women in the first trimester.
Materials and Methods
The study included 52 pregnant women who applied to the emergency gynecology clinic between the 7th and 12th weeks of pregnancy and were hospitalized due to 2+ ketonuria. The control group consisted of healthy pregnant women at the same gestational age who applied to the gynecology clinic. Statistical analysis was performed with the SPSS (Statistical package for Social Sciences-SPSS Inc., version 20.0; Chicago, IL) program.
Results
There was no statistically significant difference between the groups in terms of maternal age, parity, body mass index (BMI) and elective curettage numbers (p>0.05). When platelet, monocyte, leukocyte and lymphocyte values were compared between the two groups, no difference was found (p>0, 05). However, when neutrophil count, NLR and PLR results were evaluated, we observed a statistically significant difference (p>0.05). We also found that combined inflammatory indices, including SII and SIRI, were significantly higher in Group HEG (p=0.000 and p=0.0011, respectively).
Conclusion
The results of our study showed that neutrophil and combined systemic inflammatory indices (NLR, PLR, SII, SIRI) were associated with the presence of HEG. According to our results, NLR was determined to have the strongest diagnostic efficacy in detecting the presence of HEG.

Keywords

Combine systemic inflammatory indexes, hyperemesis gravidarum, pregnancy

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