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Comparative Analysis of ERCP Results in Two Elderly Cohorts: Late Elderly and Super-Aged Patients

Year 2025, Volume: 15 Issue: 1, 49 - 55, 31.01.2025

Abstract

Aims:
Endoscopists may generally avoid performing ERCP in super-old patients. This is because these patients often have comorbid conditions and reduced physiological function. The aim of this study was to evaluate the efficacy and safety of ERCP in the super-old population over 85 years of age.
Materials and Methods:
This study was retrospectively designed in a single tertiary care centre. Patients over 75 years of age with naive papillae who underwent ERCP between February 2019 and June 2022 were included in the study. Among the patients in the study, patients over 85 years of age were defined as süper-old, and patients aged 75-84 years were defined as old. The procedural data, efficacy and procedure-related adverse events of ERCP were compared between the two groups.
Results:
A total of 260 patients were included, with 200 (76.9%) in the old group and 60 (23.1%) in the super-old group, of whom 37 were over 90 years old. According to the results of the analyses, only age and Charlson score showed a significant difference (p<0.001) between the demographic variables. There was no significant difference between the two groups in terms of procedural success, cannulation time, difficult cannulation, cannulation techniques and other procedural data. Cardiopulmonary complications were significantly more frequent in the super-old group (8.3% versus 2%, p=0.033). The length of hospital stay was also found to be higher in the super-old group compared to the old group (p=0.005).
Conclusion:
Our study demonstrated that ERCP is a safe and effective procedure in super-old patients, with no significant difference in ERCP related adverse events between elderly groups. However, cardiopulmonary complications warrant caution and may lead to longer, more complex hospitalizations for super-aged patients undergoing ERCP.

Ethical Statement

Ethics committee approval was obtained for this study from the Bilkent City Hospital Local Ethics Committee (Date: 22.12.2021 Decision No: E2-21-1153).

Supporting Institution

The authors declared that this study has received no financial support.

References

  • 1- World Health Organization; National Institute on Aging; National Institutes of Health. Global Health and Aging. NIH Publication No. 11-7737. Published 2011.
  • 2- Andriulli, A., Loperfido, S., Napolitano, G., et al. Incidence rates of post-ERCP complications: a systematic survey of prospective studies. Official journal of the American College of Gastroenterology| ACG. 2007;102(8): 1781-1788.
  • 3- Yıldırım AE, Öztürk ZA, Konduk BT, et al. The safety and efficacy of ERCP in octogenarians: a comparison of two geriatric age cohorts. Acta Gastroenterol Belg. 2017 ;80(2):263-270.
  • 4- Han SJ, Lee TH, Kang BI, et al. Efficacy and Safety of Therapeutic Endoscopic Retrograde Cholangiopancreatography in the Elderly Over 80 Years. Dig Dis Sci. 2016;61(7):2094-3101. doi: 10.1007/s10620-016-4064-y.
  • 5- Takahashi K, Tsuyuguchi T, Sugiyama H, et al. Risk factors of adverse events in endoscopic retrograde cholangiopancreatography for patients aged ≥85 years. Geriatr Gerontol Int. 2018 ;18(7):1038-1045. doi: 10.1111/ggi.13302.
  • 6- Mazzola P, Spedale V. Commentary: Risk factors for complications in elderly patients aged 85 years and over undergoing endoscopic biliary stone removal. Front Surg. 2023; 10: 1139745. doi: 10.3389/fsurg.2023.1139745.
  • 7- Ouchi Y, Rakugi H, Arai H, et al. Joint Committee of Japan Gerontological Society (JGLS) and Japan Geriatrics Society (JGS) on the definition and classification of the elderly. Redefining the elderly as aged 75 years and older: Proposal from the Joint Committee of Japan Gerontological Society and the Japan Geriatrics Society. Geriatr Gerontol Int. 2017 ;17(7):1045-1047. doi: 10.1111/ggi.13118.
  • 8- Kazumori H, Fukuda K, Onishi K, Ohno Y. Urgent Endoscopic Retrograde Cholangiopancreatography Treatment Useful for Acute Cholangitis Caused by Bile Duct Stones in Patients Aged 90 Years and Older. Gerontology. 2024; 30:1-9. doi: 10.1159/000541636.
  • 9- Testoni PA, Mariani A, Aabakken L, et al. Papillary cannulation and sphincterotomy techniques at ERCP: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy. 2016 ;48(7):657-83. doi: 10.1055/s-0042-108641.
  • 10- ASGE Standards of Practice Committee; Chandrasekhara V, Khashab MA, Muthusamy VR, et al. Adverse events associated with ERCP. Gastrointest Endosc. 2017;85(1):32-47. doi: 10.1016/j.gie.2016.06.051.
  • 11- Yun DY, Han J, Oh JS, Park KW, Shin IH, Kim HG. Is endoscopic retrograde cholangiopancreatography safe in patients 90 years of age and older? Gut Liver. 2014 ;8(5):552-6. doi: 10.5009/gnl13310.
  • 12- Ergin E, Oruç N, Ersöz G, Tekeşin O, Özütemiz Ö. Prognosis and risk factors of ERCP pancreatitis in elderly. Sci Rep. 2021;11(1):15930. doi: 10.1038/s41598-021-95484-8. Erratum in: Sci Rep. 2021;11(1):17769. doi: 10.1038/s41598-021-97721-6.
  • 13- Sugimoto S, Hattori A, Maegawa Y, et al. Long-term Outcomes of Therapeutic Endoscopic Retrograde Cholangiopancreatography for Choledocholithiasis in Patients ≥90 Years Old: A Multicenter Retrospective Study. Intern Med. 2021;60(13):1989-1997. doi: 10.2169/internalmedicine.6478-6520.
  • 14- Pericleous S, Smith LI, Karim MA, Middleton N, Musbahi A, Ali A. Endoscopic retrograde cholangiopancreatography in Ayrshire, Scotland: a comparison of two age cohorts. Scott Med J. 2015;60(2):95-100. doi: 10.1177/0036933015576695.
  • 15- Hu L, Sun X, Hao J, et al. Long-term follow-up of therapeutic ERCP in 78 patients aged 90 years or older. Sci Rep. 2014; 4: 4918. doi: 10.1038/srep04918.
  • 16- Mohammad Alizadeh AH, Afzali ES, Shahnazi A, Sanati A, Mirsattari D, Zali MR. Utility and safety of ERCP in the elderly: a comparative study in iran. Diagn Ther Endosc. 2012; 2012: 439320. doi: 10.1155/2012/439320.
  • 17- Colmenero Gargari AE, Melgar Somoza FE, Vera J, Micames CG. ERCP in patients over 90 years old: Safety and efficacy comparison with a younger cohort. Endosc Int Open. 2023;11(9):E893-E898. doi: 10.1055/a-2153-7094.
  • 18- Tabak F, Wang HS, Li QP, et al. Endoscopic retrograde cholangiopancreatography in elderly patients: Difficult cannulation and adverse events. World J Clin Cases. 2020 ;8(14):2988-2999. doi: 10.12998/wjcc.v8.i14.2988.
  • 19- Chan KS, Mohan R, Low JK, Junnarkar SP, Huey CWT, Shelat VG. Elderly patients (≥ 80 years) with acute calculous cholangitis have similar outcomes as non-elderly patients (< 80 years): Propensity score-matched analysis. World J Hepatol. 2021;13(4):456-471.doi: 10.4254/wjh.v13.i4.456.

İki Yaşlı Hasta Grubunda ERCP Sonuçlarının Karşılaştırmalı Analizi: Yaşlı ve Süper Yaşlı Hastalar

Year 2025, Volume: 15 Issue: 1, 49 - 55, 31.01.2025

Abstract

Amaçlar:
Endoskopistler, genellikle süper yaşlı (85 yaş ve üzeri) hastalarda ERCP yapmaktan kaçınmaktadır. Bunun nedeni, bu hastaların sıklıkla komorbiditelere sahip olması ve fizyolojik rezervlerinin azalmasıdır. Bu çalışmanın amacı, 85 yaş üstü süper yaşlı popülasyonda ERCP'nin etkinliğini ve güvenliğini değerlendirmektir.
Gereç ve Yöntemler:
Bu retrospektif çalışma, üçüncü basamak bir sağlık merkezinde gerçekleştirildi. Şubat 2019 ile Haziran 2022 tarihleri arasında naive papillae ile ERCP uygulanan 75 yaş ve üstü hastalar çalışmaya dahil edildi. Hastalar, süper yaşlı (≥85 yaş) ve yaşlı (75–84 yaş) olarak sınıflandırıldı. Gruplar arasında işlem verileri, etkinlik ve ERCP’ye bağlı advers olaylar karşılaştırıldı.
Bulgular:
Çalışmaya toplam 260 hasta dahil edildi: 200’ü (%76,9) yaşlı, 60’ı (%23,1) süper yaşlı grubunda yer aldı; bu gruptaki 37 hasta 90 yaşın üzerindeydi. Süper yaşlı grubunda yaş ve Charlson skoru anlamlı derecede daha yüksekti (p<0,001). İşlemsel başarı, kanülasyon süresi, zor kanülasyon oranları ve kullanılan teknikler açısından gruplar arasında anlamlı bir fark yoktu. Ancak, süper yaşlı grupta kardiyopulmoner komplikasyonlar daha sık görüldü (%8,3 vs. %2, p=0,033) ve bu hastaların hastanede kalış süreleri daha uzundu (p=0,005).
Sonuç:
ERCP, süper yaşlı hastalar için güvenli ve etkili bir prosedür olarak görülmüştür ve yaş grupları arasında ERCP’ye bağlı advers olaylar açısından anlamlı bir fark bulunmamıştır. Bununla birlikte, süper yaşlı hastalarda kardiyopulmoner komplikasyon riskinin artması, dikkatli bir ön değerlendirme ve yönetim gerektirmektedir.

Ethical Statement

Ethics committee approval was obtained for this study from the Bilkent City Hospital Local Ethics Committee (Date: 22.12.2021 Decision No: E2-21-1153).

References

  • 1- World Health Organization; National Institute on Aging; National Institutes of Health. Global Health and Aging. NIH Publication No. 11-7737. Published 2011.
  • 2- Andriulli, A., Loperfido, S., Napolitano, G., et al. Incidence rates of post-ERCP complications: a systematic survey of prospective studies. Official journal of the American College of Gastroenterology| ACG. 2007;102(8): 1781-1788.
  • 3- Yıldırım AE, Öztürk ZA, Konduk BT, et al. The safety and efficacy of ERCP in octogenarians: a comparison of two geriatric age cohorts. Acta Gastroenterol Belg. 2017 ;80(2):263-270.
  • 4- Han SJ, Lee TH, Kang BI, et al. Efficacy and Safety of Therapeutic Endoscopic Retrograde Cholangiopancreatography in the Elderly Over 80 Years. Dig Dis Sci. 2016;61(7):2094-3101. doi: 10.1007/s10620-016-4064-y.
  • 5- Takahashi K, Tsuyuguchi T, Sugiyama H, et al. Risk factors of adverse events in endoscopic retrograde cholangiopancreatography for patients aged ≥85 years. Geriatr Gerontol Int. 2018 ;18(7):1038-1045. doi: 10.1111/ggi.13302.
  • 6- Mazzola P, Spedale V. Commentary: Risk factors for complications in elderly patients aged 85 years and over undergoing endoscopic biliary stone removal. Front Surg. 2023; 10: 1139745. doi: 10.3389/fsurg.2023.1139745.
  • 7- Ouchi Y, Rakugi H, Arai H, et al. Joint Committee of Japan Gerontological Society (JGLS) and Japan Geriatrics Society (JGS) on the definition and classification of the elderly. Redefining the elderly as aged 75 years and older: Proposal from the Joint Committee of Japan Gerontological Society and the Japan Geriatrics Society. Geriatr Gerontol Int. 2017 ;17(7):1045-1047. doi: 10.1111/ggi.13118.
  • 8- Kazumori H, Fukuda K, Onishi K, Ohno Y. Urgent Endoscopic Retrograde Cholangiopancreatography Treatment Useful for Acute Cholangitis Caused by Bile Duct Stones in Patients Aged 90 Years and Older. Gerontology. 2024; 30:1-9. doi: 10.1159/000541636.
  • 9- Testoni PA, Mariani A, Aabakken L, et al. Papillary cannulation and sphincterotomy techniques at ERCP: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy. 2016 ;48(7):657-83. doi: 10.1055/s-0042-108641.
  • 10- ASGE Standards of Practice Committee; Chandrasekhara V, Khashab MA, Muthusamy VR, et al. Adverse events associated with ERCP. Gastrointest Endosc. 2017;85(1):32-47. doi: 10.1016/j.gie.2016.06.051.
  • 11- Yun DY, Han J, Oh JS, Park KW, Shin IH, Kim HG. Is endoscopic retrograde cholangiopancreatography safe in patients 90 years of age and older? Gut Liver. 2014 ;8(5):552-6. doi: 10.5009/gnl13310.
  • 12- Ergin E, Oruç N, Ersöz G, Tekeşin O, Özütemiz Ö. Prognosis and risk factors of ERCP pancreatitis in elderly. Sci Rep. 2021;11(1):15930. doi: 10.1038/s41598-021-95484-8. Erratum in: Sci Rep. 2021;11(1):17769. doi: 10.1038/s41598-021-97721-6.
  • 13- Sugimoto S, Hattori A, Maegawa Y, et al. Long-term Outcomes of Therapeutic Endoscopic Retrograde Cholangiopancreatography for Choledocholithiasis in Patients ≥90 Years Old: A Multicenter Retrospective Study. Intern Med. 2021;60(13):1989-1997. doi: 10.2169/internalmedicine.6478-6520.
  • 14- Pericleous S, Smith LI, Karim MA, Middleton N, Musbahi A, Ali A. Endoscopic retrograde cholangiopancreatography in Ayrshire, Scotland: a comparison of two age cohorts. Scott Med J. 2015;60(2):95-100. doi: 10.1177/0036933015576695.
  • 15- Hu L, Sun X, Hao J, et al. Long-term follow-up of therapeutic ERCP in 78 patients aged 90 years or older. Sci Rep. 2014; 4: 4918. doi: 10.1038/srep04918.
  • 16- Mohammad Alizadeh AH, Afzali ES, Shahnazi A, Sanati A, Mirsattari D, Zali MR. Utility and safety of ERCP in the elderly: a comparative study in iran. Diagn Ther Endosc. 2012; 2012: 439320. doi: 10.1155/2012/439320.
  • 17- Colmenero Gargari AE, Melgar Somoza FE, Vera J, Micames CG. ERCP in patients over 90 years old: Safety and efficacy comparison with a younger cohort. Endosc Int Open. 2023;11(9):E893-E898. doi: 10.1055/a-2153-7094.
  • 18- Tabak F, Wang HS, Li QP, et al. Endoscopic retrograde cholangiopancreatography in elderly patients: Difficult cannulation and adverse events. World J Clin Cases. 2020 ;8(14):2988-2999. doi: 10.12998/wjcc.v8.i14.2988.
  • 19- Chan KS, Mohan R, Low JK, Junnarkar SP, Huey CWT, Shelat VG. Elderly patients (≥ 80 years) with acute calculous cholangitis have similar outcomes as non-elderly patients (< 80 years): Propensity score-matched analysis. World J Hepatol. 2021;13(4):456-471.doi: 10.4254/wjh.v13.i4.456.
There are 19 citations in total.

Details

Primary Language English
Subjects Gastroenterology and Hepatology
Journal Section Original Research
Authors

Rasim Eren Cankurtaran 0000-0002-3687-3845

Osman Ersoy 0000-0002-1364-5962

Publication Date January 31, 2025
Submission Date December 30, 2024
Acceptance Date January 27, 2025
Published in Issue Year 2025 Volume: 15 Issue: 1

Cite

AMA Cankurtaran RE, Ersoy O. Comparative Analysis of ERCP Results in Two Elderly Cohorts: Late Elderly and Super-Aged Patients. J Contemp Med. January 2025;15(1):49-55.