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Year 2019, , 10 - 10, 21.06.2019
https://doi.org/10.37212/jcnos.584684

Abstract

References

  • Branca JJV, Morucci G, Pacini A. 2018. Cadmium-induced neurotoxicity: still much ado. Neural Regen Res. 13(11): 1879– 1882.
  • Kanter M, Aktoz T, Aktas C, Ozen F, Yarali O, Kanter B. 2016. Role of Quercetin in Cadmium-Induced Oxidative Stress, Testicular Damage, and Apoptosis in Rats. Anal Quant Cytopathol Histpathol. 38(1):45–51.

The effects of quercetin on antioxidant and cytokine levels in rat hippocampus exposed to acute cadmium toxicity

Year 2019, , 10 - 10, 21.06.2019
https://doi.org/10.37212/jcnos.584684

Abstract

 The aim of this study was to determine cadmium neurotoxicity (Branca et al.  2018) and beneficial effect of quercetin (QE) (Kanter et al.  2016) against on neuronal damage in hippocampus exposed with acute cadmium (Cd). Adult male Wistar-Albino rats (n = 30) were used and divided into four groups as Control (C, n = 6), Cadmium (Cd, n = 8), Quercetin (Q, n = 8) and Cadmium + Quercetin (Cd + Q, n = 8). Cadmium (CdCl2, 4 mg kg-1 daily, s.c) were administrated to Cd and Cd+Q groups, and Quercetin (Q, 50 mg kg-1 daily, i.p) were administrated to Q and Cd + Q groups for 3 days, respectively. At 4th day after the treatments, hippocampal samples were taken from the four groups. Cadmium decreased superoxide dismutase (SOD) and reduced glutathione (GSH) levels and the SOD activity and GSH level were markedly (p< 0.05) lower in Cd group than in the Q and C groups. Lipid peroxidation (MDA) levels were higher in Cd group when compared to the control, Q and Cd+Q groups. IL1 levels were found statistically higher in Cd group than in the control, Q and Cd+Q groups. IL-6 and TNF-alfa levels were significantly (p< 0.05) higher in Cd and Cd+Q groups than the Q and C groups.  In addition, IL10 levels were detected the lowest in Cd group when compared to other groups.      In conclusion, our results show that quercetin can be beneficial against to neurotoxic effects of acute cadmium toxicity in the rat hippocampus through upregulation of antioxidant system but down regulation of cytokine levels. 

References

  • Branca JJV, Morucci G, Pacini A. 2018. Cadmium-induced neurotoxicity: still much ado. Neural Regen Res. 13(11): 1879– 1882.
  • Kanter M, Aktoz T, Aktas C, Ozen F, Yarali O, Kanter B. 2016. Role of Quercetin in Cadmium-Induced Oxidative Stress, Testicular Damage, and Apoptosis in Rats. Anal Quant Cytopathol Histpathol. 38(1):45–51.
There are 2 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Original Articles
Authors

İhsan Kısadere

Nurcan Dönmez

Hasan Hüseyin Dönmez

Publication Date June 21, 2019
Published in Issue Year 2019

Cite

APA Kısadere, İ., Dönmez, N., & Dönmez, H. H. (2019). The effects of quercetin on antioxidant and cytokine levels in rat hippocampus exposed to acute cadmium toxicity. Journal of Cellular Neuroscience and Oxidative Stress, 11, 10-10. https://doi.org/10.37212/jcnos.584684
AMA Kısadere İ, Dönmez N, Dönmez HH. The effects of quercetin on antioxidant and cytokine levels in rat hippocampus exposed to acute cadmium toxicity. J Cell Neurosci Oxid Stress. June 2019;11:10-10. doi:10.37212/jcnos.584684
Chicago Kısadere, İhsan, Nurcan Dönmez, and Hasan Hüseyin Dönmez. “The Effects of Quercetin on Antioxidant and Cytokine Levels in Rat Hippocampus Exposed to Acute Cadmium Toxicity”. Journal of Cellular Neuroscience and Oxidative Stress 11, June (June 2019): 10-10. https://doi.org/10.37212/jcnos.584684.
EndNote Kısadere İ, Dönmez N, Dönmez HH (June 1, 2019) The effects of quercetin on antioxidant and cytokine levels in rat hippocampus exposed to acute cadmium toxicity. Journal of Cellular Neuroscience and Oxidative Stress 11 10–10.
IEEE İ. Kısadere, N. Dönmez, and H. H. Dönmez, “The effects of quercetin on antioxidant and cytokine levels in rat hippocampus exposed to acute cadmium toxicity”, J Cell Neurosci Oxid Stress, vol. 11, pp. 10–10, 2019, doi: 10.37212/jcnos.584684.
ISNAD Kısadere, İhsan et al. “The Effects of Quercetin on Antioxidant and Cytokine Levels in Rat Hippocampus Exposed to Acute Cadmium Toxicity”. Journal of Cellular Neuroscience and Oxidative Stress 11 (June 2019), 10-10. https://doi.org/10.37212/jcnos.584684.
JAMA Kısadere İ, Dönmez N, Dönmez HH. The effects of quercetin on antioxidant and cytokine levels in rat hippocampus exposed to acute cadmium toxicity. J Cell Neurosci Oxid Stress. 2019;11:10–10.
MLA Kısadere, İhsan et al. “The Effects of Quercetin on Antioxidant and Cytokine Levels in Rat Hippocampus Exposed to Acute Cadmium Toxicity”. Journal of Cellular Neuroscience and Oxidative Stress, vol. 11, 2019, pp. 10-10, doi:10.37212/jcnos.584684.
Vancouver Kısadere İ, Dönmez N, Dönmez HH. The effects of quercetin on antioxidant and cytokine levels in rat hippocampus exposed to acute cadmium toxicity. J Cell Neurosci Oxid Stress. 2019;11:10-.