Experimental traumatic brain injury models in rodents

Year 2019, Cilt 11 Supp 1 (BRS), 13 - 13, 21.06.2019

Özgür Öcal

https://doi.org/10.37212/jcnos.584693

Abstract

Several accidents such as sport and traffic may induce head trauma for inducing mild traumatic brain injuries. Then the mild traumatic brain injuries result in primary and secondary brain injuries for resulting neurodegenerative disorders. Investigation of the traumatic brain injuries in the subject are difficult due to ethical restrictions. In addition, results of postmortem analyses of mild traumatic brain injuries are not valuable for clarifying the etiology of the mild traumatic brain injuries. Therefore, the animal models have great importance for the clarifying etiology of the mild traumatic brain injuries. Today, there are several animal models of mild traumatic brain injuries such as models of Marmarou, Feeney and Maryland (Marmarou et al. 1994; Hiskens et al. 2019). However, they are severe and acute models instead of the mild traumatic brain injuries. Recently, Dr. Mehmet Bilgen from USA discovered a valuable mechanical technique for the injuries (Bilgen, 2005). This presentation, I aimed to examine the literature for variables included in these animal models. Present data on the experimental traumatic brain injury suggested that appropriate animal models can assist in understanding the pathophysiological outcomes of patients with traumatic brain injury. The animal models could be used for discovering new therapies in the treatment of traumatic brain injuries.

Keywords

Traumatic brain injury, Neurodegenerative diseases, Marmarou’ model, Experimental Animals

References

• Hiskens MI, Angoa-Pérez M, Schneiders AG, Vella RK, Fenning AS. 2019. Modeling sports-related mild traumatic brain injury in animals-A systematic review. J Neurosci Res. doi: 10.1002/jnr.24472. [Epub ahead of print].
• Marmarou A, Foda MA, Brink WVB, Campbell J, Kita H, Demetriadou K. 1994. A new model of diffuse brain injury in rats. J Neurosurg 80:291-300.
• Bilgen M. 2005. A new device for experimental modeling of central nervous system injuries. Neurorehabil Neural Repair. 19(3):219-126.