Abstract Book of 5th International Brain Research School, 16-22 November 2020, Isparta /TURKEY http://2020.brs.org.tr

Year 2020, Volume: 12 Issue: Supplement, 1 - 16, 24.11.2020

Anonymous Anonymous

https://doi.org/10.37212/jcnos.830831

Cited By: 1

Abstract

5th International Brain Research School (BRS2020) was performed between 16 and 22 November 2020, Isparta /TURKEY (http://2020.brs.org.tr). There were 7 conference presentations and 9 oral presentations in the BRS2020. Abstracts of the presentations were published in the issue.
Speakers and titles
1. Calcium imaging and laser confocal microscopy analyses in the microglia. Dr. Mustafa NAZIROĞLU.
2. A mouse model for age-related macular degeneration. Dr. Xinhua SHU.
3. Western-blot, PCR, and immunofluorescence analysis in mitochondrial biogenesis studies. Dr. Denis ROUSSEAU.
4. Drug-induced plasticity: How and where? Dr. Plinio CASAROTTO.
5. Principles of Ca2+ imaging using low-affinity indicators. Dr. Marco CANEPARI.
6. Transcriptional and epigenetic dysregulation in Huntington's disease. Dr. Ferah YILDIRIM.
7. Voltage gated sodium channels and epilepsy. Dr. Simon HEBEISEN.

Keywords

Brain, Patch-clamp, Laser confocal microscope, Epilepsy, Alzheimer, Stress, Pain, Depression

References

• Alkis ME, Bilgin HM, Akpolat V, Dasdag S, Yegin K, Yavas MC, Akdag MZ. 2019. Effect of 900-, 1800-, and 2100-MHz radiofrequency radiation on DNA and oxidative stress in brain. Electromagn Biol Med. 38(1):32-47.
• Aynalı G, Nazıroğlu M, Çelik Ö, Doğan M, Yarıktaş M, Yasan H. 2013. Modulation of wireless (2.45 GHz)-induced oxidative toxicity in laryngotracheal mucosa of rat by melatonin. Eur Arch Otorhinolaryngol. 270:1695-700.
• Balaban H, Nazıroğlu M, Demirci K, Övey İS. 2017. The protective role of selenium on scopolamine-induced memory impairment, oxidative stress, and apoptosis in aged rats: The involvement of TRPM2 and TRPV1 channels. Mol Neurobiol. 54(4):2852- 2868.
• Baş E, Nazıroğlu M, Pecze L. 2019. ADP-Ribose and oxidative stress activate TRPM8 channel in prostate cancer and kidney cells.
• Bidaux G, Borowiec AS, Dubois C, Delcourt P, Schulz C, Vanden Abeele F, Lepage G, Desruelles E, Bokhobza A, Dewailly E, Slomianny C, Roudbaraki M, Héliot L, Bonnal JL, Mauroy B, Mariot P, Lemonnier L, Prevarskaya N. 2016. Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells. Oncotarget 7(20):29063- 29080.
• Bohonyi N, Pohóczky K, Szalontai B, Perkecz A, Kovács K, Kajtár B, Orbán L, Varga T, Szegedi S, Bódis J, Helyes Z, Koppán M. 2017. Local upregulation of transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 ion channels in rectosigmoid deep infiltrating endometriosis. Mol Pain. 13:1744806917705564.
• Brito R, Sheth S, Mukherjea D, Rybak LP, Ramkumar V. 2014. TRPV1: A Potential Drug Target for Treating Various Diseases. Cells 3(2):517-45.
• Chuang HH, Neuhausser WM, Julius D. 2004. The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron 43(6):859-869.
• Clapham DE. 2003. TRP channels as cellular sensors. Nature. 426(6966):517-524. Miller BA, Cheung JY. 2016. TRPM2 protects against tissue damage following oxidative stress and ischaemia-reperfusion. J Physiol. 594(15):4181-4191.
• Davalli P, Mitic T, Caporali A, Lauriola A, D’Arca D. 2016. ROS, cell senescence, and novel molecular mechanisms in aging and age-related diseases. Oxid Med Cell Longev. 3565127.
• de Melo Reis RA, Freitas HR, de Mello FG. 2020. Cell calcium imaging as a reliable method to study neuron-glial circuits. Front Neurosci. 14:569361.
• Donmez G. 2012. The neurobiology of sirtuins and their role in neurodegeneration. Trends Pharmacol Sci. 33(9):494–501.
• Ekici Eİ, Güney M, Nazıroğlu M. 2020. Protective effect of cabergoline on mitochondrial oxidative stress-induced apoptozis is mediated by modulations of TRPM2 in neutrophils of patiens with endometriosis. J Bioenerg Biomembr.52(3):131-142.
• Finkel T, Deng CX, Mostoslavsky R. 2009. Recent progress in the biology and physiology of sirtuins. Nature 460:587-591.
• Goenka L, George M, Sen M. 2017. A peek into the drug development scenario of endometriosis - A systematic review. Biomed Pharmacother. 90:575-585.
• Greaves E, Grieve K, Horne AW, Saunders PT. 2014. Elevated peritoneal expression and estrogen regulation of nociceptive ion channels in endometriosis. J Clin Endocrinol Metab. 99(9):E1738-E1743.
• Haigis MC, Sinclair DA. 2010. Mammalian sirtuins: Biological insights and disease relevance. Annu Rev Pathol. 5:253–295.
• Hall H, Reyes S, Landeck N, Bye C, Leanza G, Double K, Thompson L, Halliday G, Kirik D. 2014. Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease. Brain. 137(Pt 9):2493-508.
• Hussain S, Manuel CT, Protsenko DE, Wong BJ. 2015. Electromechanical reshaping of ex vivo porcine trachea. The Laryngoscope, 125.7: 1628-1632.
• Kahya MC, Nazıroğlu M, Övey İS. 2017. Modulation of diabetesinduced oxidative stress, apoptosis, and Ca2+ entry through TRPM2 and TRPV1 channels in dorsal root ganglion and hippocampus of diabetic rats by melatonin and selenium. Mol Neurobiol. 54:2345-2360.
• Kumar VS, Gopalakrishnan A, Nazıroğlu M, Rajanikant GK. 2014. Calcium ion--the key player in cerebral ischemia. Curr Med Chem. 21(18):2065-2075.
• Ogawa N, Kurokawa T, Fujiwara K, Polat OK, Badr H, Takahashi N, Mori Y. (2016) Functional and structural divergence in human TRPV1 channel subunits by oxidative cysteine modification. J Biol Chem. 291:4197-4210. Sci Rep. 9(1):4100.
• Sun Y, Sukumaran P, Selvaraj S, Cilz NI, Schaar A, Lei S, Singh BB. 2018. TRPM2 Promotes Neurotoxin MPP(+)/MPTP-Induced Cell Death. Mol Neurobiol. 55(1):409-420.
• Yıldızhan K, Nazıroğlu M. 2020. Glutathione depletion and parkinsonian neurotoxin MPP+-induced TRPM2 channel activation play central roles in oxidative cytotoxicity and inflammation in microglia. Mol Neurobiol. 57(8):3508-3525.
• Yürüker V, Nazıroğlu M, Şenol N. 2015. Reduction in traumatic brain injury-induced oxidative stress, apoptosis, and calcium entry in rat hippocampus by melatonin: Possible involvement of TRPM2 channels. Metab Brain Dis. 30(1):223-31.
• Zong C, Ji Y, He Q, Zhu S, Qin F, Tong J, Cao Y. 2015. Adaptive response in mice exposed to 900 MHZ radiofrequency fields: bleomycin-induced DNA and oxidative damage/repair. Int J Radiat Biol. 91(3):270-276.