INVESTIGATION OF THE RELATION BETWEEN DOPAMINE DEPLETION AND THE SLOWING OF ALPHA RHYTHM IN ELECTROENCEPHALOGRAM OF THALAMUS

Abstract

A hybrid computational model of thalamo-cortical circuitry and basal ganglia is used to investigate the relation between the electroencephalogram (EEG) changes within the alpha frequency bands in thalamic region depending on the decrease in the dopamine level in striatum.  Since it is known that in the diseases such as Alzheimer and Parkinson, the level of dopamine decreases, the related changes in thalamic region is investigated considering the dopamine depletion. The diseases affects the dopamine decrease in different ways, such that in Parkinsonian disease (PD), the total amount of dopamine affecting striatal neurons decreases whereas in Alzheimer disease (AD), the dopamine level decreases mostly in D2 dopamine receptor neurons. Therefore, these differences are analyzed to investigate the slowing of alpha rhythm on EEG of thalamus by using the modified mass model of thalamic region. It is observed that the decrease in the amount of dopamine causes shift of the power in alpha bands to lower frequencies. When the dopamine level is decreased in D1 and D2 type MSN neurons, the slowing of alpha rhythm in EEG of thalamus is prominent. 

Keywords

• Alzheimer disease,EEG,dopamine

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