INVESTIGATION OF THE RELATION BETWEEN DOPAMINE DEPLETION AND THE SLOWING OF ALPHA RHYTHM IN ELECTROENCEPHALOGRAM OF THALAMUS

Year 2019, Volume: 4 Issue: 1, 22 - 27, 30.06.2019

Yüksel Çakir

Abstract

A hybrid computational model of thalamo-cortical
circuitry and basal ganglia is used to investigate the relation between the
electroencephalogram (EEG) changes within the alpha frequency bands in thalamic
region depending on the decrease in the dopamine level in striatum.  Since it is known that in the diseases such
as Alzheimer and Parkinson, the level of dopamine decreases, the related
changes in thalamic region is investigated considering the dopamine depletion. The
diseases affects the dopamine decrease in different ways, such that in
Parkinsonian disease (PD), the total amount of dopamine affecting striatal
neurons decreases whereas in Alzheimer disease (AD), the dopamine level
decreases mostly in D2 dopamine receptor neurons. Therefore, these differences
are analyzed to investigate the slowing of alpha rhythm on EEG of thalamus by
using the modified mass model of thalamic region. It is observed that the
decrease in the amount of dopamine causes shift of the power in alpha bands to
lower frequencies. When the dopamine level is decreased in D1 and D2 type MSN
neurons, the slowing of alpha rhythm in EEG of thalamus is prominent. 

Keywords

Alzheimer disease, EEG, dopamine

Supporting Institution

TUBITAK BIDEB

Project Number

2219

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