The instructional design of ethnoscience-based inquiry learning for scientific explanation about Taxus sumatrana as cancer medication

Abstract

The ethnoscience approach is carried out by integrating local wisdom culture in science learning. The Minang community believes that the Taxus sumatrana plant is a cancer drug. But they have not been able to explain its benefits conceptually based on scientific inquiry with relevant references. This study aims to solve these problems through (1) designing ethnoscience-based inquiry learning to study the bioactivity of Taxus sumatrana; and (2) describe scientific experiments on plants as cancer drugs. This research includes qualitative research to reconstruct scientific explanations based on local wisdom. The data were obtained through observations at the research location regarding community local wisdom and laboratory activities including isolation, phytochemical identification, and chemical structure testing using Perkin Elmer 100 FT-IR spectroscopy. All data obtained were analyzed and corroborated by various relevant sources. The results of the analysis concluded that the appropriate learning design was an integrated model; and secondary metabolites found in the bark and leaves of Taxus sumatrana were tested using water, ethanol, ethanol + n-hexane, and ethanol + benzene as solvents, including terpenoids, alkaloids, terpenoids, steroids, phenolics, and saponins. The results showed that Taxus sumatrana can act as an anticancer because in the experimental laboratory it is known that terpenoids as taxols, phenolics, and other oxygenated metabolites which have the potential to be anticancer

Keywords

• Taxus sumatrana
• Cancer medication
• Ethnoscience-based inquiry learning
• Instructional design
• Scientific explanation

Supporting Institution

The Indonesian Ministry of Research and Technology

Thanks

Thank you to the Indonesian Ministry of Research and Technology for funding this research, so that this research can be carried out.

References

1. Achmad, S. A. (2009). Indonesian Biological Resources Chemistry: Research for the Development of Education, Science, and Human Resources.
2. Ahmad Khoiri, W. S. (2019). Pendekatan Etnosains dalam Tinjauan Filsafat. Spektra: Jurnal Kajian Pendidikan Sains, 6(1).
3. Artanti N, M. H. (2002). Inhibitory activity of gambier extract (Uncaria gambir Roxb) and Taxus sumatrana (Miquel) de Laubenfels extract against α-glucosidase enzyme. Proceedings of the Scientific Meeting of the Indonesian Chemical Cooperation Network, 483–488. National Seminar on Chemistry in Development.
4. Bhasin, V. (2017). Medical Anthropology: A Review. Studies on Ethno-Medicine, 1(1), 1–20. https://doi.org/10.1080/09735070.2007.11886296
5. Dachriyanus. (2004). Analisis Struktur Senyawa Organik Secara Spektroskopi. Retrieved from tersedia: https://www.google.com/ search? client =firefox-b d&q= karak-teristik+ spektra+ infrared+benzena.
6. Dhama. (2013). Herbal Remedies To Combat Cancers In Humans And Animals – A Review. International Journal of Current Research, 5, 1908–1919.
7. Do Couto, H. H. (2014). Ecological approaches in linguistics: A historical overview. Language Sciences, 41, 122–128. https://doi.org/10.1016/j.langsci.2013.08.001
8. Earle, C. J. (2013). Taxus sumatrana (Miquel) de Laubenfels tersedia.

9. Farrar, J. L. (1995). Trees in Canada. Canadian Forest Service and Fitzhenry & Whiteside Ltd. Markham ON. 502 P.
10. Fasasi, R. A. (2017). Effects of ethnoscience instruction, school location, and parental educational status on learners’ attitude towards science. International Journal of Science Education, 39(5), 548–564. https://doi.org/10.1080/09500693.2017.1296599
11. Fitria, M. (2018). The Development of Ethnoscience-Based Chemical Enrichment Book as a Science Literacy Sorce of Students. IJCER, 2(1).
12. Ghafoori, R. (2012). Improved effect of glutathione on the induction and growth of Taxus baccata L. Callus. Annals of Biological Research, 3(4), 1726–1730.
13. Graffigna, G., Vegni, E., Barello, S., Olson, K., & Bosio, C. A. (2011a). Studying the social construction of cancer-related fatigue experience: The heuristic value of Ethnoscience. Patient Education and Counseling, 82(3), 402–409. https://doi.org/10.1016/j.pec.2010.12.017
14. Graffigna, G., Vegni, E., Barello, S., Olson, K., & Bosio, C. A. (2011b). Studying the social construction of cancer-related fatigue experience: The heuristic value of Ethnoscience. Patient Education and Counseling, 82(3), 402–409. https://doi.org/10.1016/j.pec.2010.12.017
15. Guang-li, S. (2010). Seed rain and seed bank of Chinese yew (Taxus chinensis var. mairei) population. Acta Ecologica Sinica, 30(5), 276–279.
16. Hakim, L. (2014). Ethnobotany and Home Garden Management: Food Security, Health and Agro-tourism. Malang: Publishers are in sync.
17. Hempel, C. (2014). Scientific Explanation, Stanford Encyclopedia Philosophy.
18. Hidayat, A. (2013). Taxol and Its Related Compound from the Bark of Taxus sumatrana. Paper, Presented at the International Seminar of Forest and Medicinal Plants for Better Human Welfare, Bogor, 10–12 September 2013.
19. Hidayat, A. (2014). Taxus sumatrana, mutiara terpendam dari zamrud Sumatera. Bogor: Forda press.
20. Jumini, S. (2016). Problem Based Learning Berbasis Inquiry ditinjau dari Sikap Ilmiah dan Kreativitas Mahasiswa. Spektra: Jurnal Kajian Pendidikan Sains, 2(1).
21. Jumini, S., & Sutikno. (2019). Physics Learning Integrated Science, Technology, Enterpreneurship. International Journal of Advanced Multidisciplinary Scientific Research (IJAMSR), 2(12), 1–16. https://doi.org/10.31426/ijamsr.2019.2.12.2511
22. Kaya, S., Erduran, S., Birdthistle, N., & McCormack, O. (2018). Looking at the Social Aspects of Nature of Science in Science Education Through a New Lens: The Role of Economics and Entrepreneurship. Science and Education, 27(5–6), 457–478. https://doi.org/10.1007/s11191-018-9990-y
23. Khory, M. (2019). Taxus sumatrana Cancer Drug, LIPI: Abundant Antioxidant Active Compounds. Tempo Report. Co, August 15, 2019.
24. Kirshbaum, M. N., Olson, K., Pongthavornkamol, K., & Graffigna, G. (2013). Understanding the meaning of fatigue at the end of life: An ethnoscience approach. European Journal of Oncology Nursing, 17(2), 146–153. https://doi.org/10.1016/j.ejon.2012.04.007
25. Kitagawa, I. (1995). Taxol and its related taxoid from the needles of Taxus sumatrana. Chem.Pham. Bull.
26. Lung-Guang, N. (2019). Decision-making determinants of students participating in MOOCs: Merging the theory of planned behavior and self-regulated learning model. Computers & Education, 134, 50–62. https://doi.org/10.1016/j.compedu.2019.02.004
27. Manar, P. A. (2018). Ethnopharmacological Knowledge of Alang-Alang (Imperatacylindrica L.) Plants by Several Ethnic Communities in Indonesia. TM Conference Series 01 (2018): 114–116,.
28. Mangkurat, M. T. of U. L. (2017). Komponen Metabolit Sekunder Bajakah. Banjarmasin: Universitas Lambung Mangkurat.
29. Matsjeh, S. (2009). Utilization of Potential Natural Vegetable Materials as Raw Materials for Medicinal Compounds. Guest Speaker Paper for the National Seminar. at the Faculty of Pharmacy, Tanjungpura University, February 16, 2009.
30. Mondaya, A. (2019). Seven Amazing Endemic and Typical Flora of Sumatra. Retrieved from https://www.abangnji.com/2019/08/ flora-endemic-sumatera. Html. National Research Council (NRC) (2011). Inquiry and the National Science Education Standards: A Guifor Teaching and Learning. Wahington, DC. NationalAcademy Press.
31. Priscylio, G., & Anwar, S. (2019). Integration of Natural Science Teaching Materials Using Robin Fogarty’s Model for the Science Learning Process in Junior High Schools. Jurnal Pijar Mipa, 14(1), 1. https://doi.org/10.29303/jpm.v14i1.966
32. Richard Decaprio. (2017). Panduan Mengembangkan Kecerdasan Motorik Siswa. Jogjakarta: Diva Press.
33. Roumy, V., Ruiz, L., Ruiz Macedo, J. C., Gutierrez-Choquevilca, A.-L., Samaillie, J., Encinas, L. A., … Hennebelle, T. (2020). Viral hepatitis in the Peruvian Amazon: Ethnomedical context and phytomedical resource. Journal of Ethnopharmacology, 255, 112735. https://doi.org/10.1016/j.jep.2020.112735
34. Shen Y-C., Lin Y-S., Cheng Y-B., Cheng K-C., T.K. Khalil, Kuo Y-H., Chien C-T. and Lin Y-C. (2005). Novel Taxane diterpenes from Taxus sumatrana with the first C-21 Taxane ester. Tetrahedron, 61, 1345–1352..
35. Spjut. (2007). Taxonomy and Nomenclature of Taxus (Taxaceae). Journal of the Botanical Institute of Texas, 1(1), 203–289.
36. Sudarmin. (2018). Pendidikan Karakter, Ethnosains, dan Kearifan Lokal. Semarang: FMIPA UNNES.
37. Sudarmin. (2019). Development of Local Wisdom Based Science Learning Model. Semarang.
38. Sudarmin. (2020). Student Worksheet on Bioactivity Test for Secondary Metabolite Compounds from Indonesian Tropical Forest Plants [Sample: Bajakah, Taxus Sumatrana, Yellow Root, Jenitri, and Mangrove]. Semarang: UNNES Press.
39. Sudarmin, S., Sumarni, W., Zahro, L., Diba, P. F., & Rosita, A. (2018). The Development of Learning Chemistry Module Integrated with Green Chemistry and Ethnoscience to Development of Students’ Generic Science Skills and Soft Skills of Conservation in Central Java. Journal of Science and Mathematics Education in Southeast Asia, 41, 5.
40. Sumarni, W., Wardani, S., Sudarmin, S., & Gupitasari, D. N. (2016). Project based learning (PBL) to improve psychomotoric skills: A classroom action research. Jurnal Pendidikan IPA Indonesia, 5(2), 157–163. https://doi.org/10.15294/jpii.v5i2.4402
41. Supartono. (2016). Experiment of Organic Chemistry 2. Semarang.
42. Walujo, E. (2013). Ethnopharmacology: Knowledge Science for the Development of Medicinal and Pharmaceutical Chemical Industry in Indonesia.
43. Weiskopf, D. A. (2020). Representing and coordinating ethnobiological knowledge. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, 101328. https://doi.org/10.1016/j.shpsc.2020.101328
44. Yin, R.K. (2016). Qualitative Research from Start to Finish, Second Edition. New York: The Guilford Press.
45. Yuliana, & Hidayat, H. (2017). How to Implement Technology Science for Entrepreneurship by Using Product-Based Learning Approach and Participatory Action Learning System in Higher Education? Advanced Science Letters, 23(11), 10918–10921. https://doi.org/10.1166/asl.2017.10186
46. Zappes, C. A., Simões-Lopes, P. C., Andriolo, A., & Di Beneditto, A. P. M. (2016). Traditional knowledge identifies causes of bycatch on bottlenose dolphins (Tursiops truncatus Montagu 1821): An ethnobiological approach. Ocean & Coastal Management, 120, 160–169. https://doi.org/10.1016/j.ocecoaman.2015.12.006
47. Zidny, R., & Eilks, I. (2020). Integrating perspectives from indigenous knowledge and Western science in secondary and higher chemistry learning to contribute to sustainability education. Sustainable Chemistry and Pharmacy, 16, 100229. https://doi.org/10.1016/j.scp.2020.100229