A Case of Pulmonary Embolism after to Receiving a Dose of Sildenafil

Year 2024, , 53 - 55, 28.06.2024

Emin Fatih Vişneci , Tevhid Aydın , Fatih Cemal Tekin , Demet Acar

https://doi.org/10.33706/jemcr.1398042

Cited By: 1

Abstract

Introduction: Several studies have posited the potential of PDE5Is to precipitate arterial and venous thrombotic or embolic incidents, albeit rare occurrences. The present investigation documents a case of pulmonary thromboembolism (PTE) in an elderly male patient, aged 81, following the consumption of sildenafil. Case Report: An 81-year-old male patient who was previously diagnosed with syncope was admitted to our Emergency Department. He reported symptoms of dyspnea and vertigo. Approximately two hours before admission, there was a history of accidentally ingesting a total dose of 100 milligrams of sildenafil. Conclusion: The occurrence of PTE after sildenafil administration in this case, albeit rare, underscores the significance of meticulous evaluation of medications during patient history-taking. This case report, the importance of thorough efforts to rule out the diagnosis of PTE and to address even the slightest suspicion.

Keywords

Pulmonary embolism, phosphodiesterase 5 inhibitors, adverse effect

References

• 1. Smith BP, Babos M. Sildenafil. 2023 Feb 14. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32644404.
• 2. Pușcașu C, Zanfirescu A, Negreș S, Șeremet OC. ExploringtheMultifacetedPotential of Sildenafil in Medicine. Medicina. 2023; 59(12):2190. doi.org/10.3390/medicina59122190.
• 3. Tsertsvadze A, Yazdi F, Fink HA, et al. Oral sildenafilcitrate (viagra) for erectile dysfunction: a systematic review and meta-analysis of harms. Urology 2009; 74:831.
• 4. Feenstra J, van Drie-Pierik RJ, Lacle´ CF, Stricker BH. Acute myocardial infarction associated with sildenafil. Lancet. 1998; 352:957–8.
• 5. Rufa A, Cerase A, Monti L, et al. Recurrent venous thrombosis including cerebral venoussinus thrombosis in a patient taking sildenafil for erectile dysfunction. J Neurol Sci. 2007;260:293–5.
• 6. Schwarz ER, Kapur V, Rastogi S, Rosanio S. Theeffect of chronic phosphodiesterase-5 inhibitoruse on different organ systems. Int J ImpotRes 2007;19:139–48.
• 7. Elsayed YMH. Sildenafil serious emergency presentations; starting with angina, myocardial infarctions, ventricular fibrillation, and ending with death; retrospective observational study (13-report cases). Acci Anesand Crit Care Open A Open J. 2019; I(1): 13-20
• 8. Ekmekyapar M, Şahin L, Gürbüz Ş. Comparison of Auxiliary Diagnostic Methods in Pulmonary Embolism. MedRecords. 2021;3(3):204-209.
• 9. Chen HC, Wang CS, Chuang SH, Wang CY. Pulmonary embolism after tadalafil ingestion. Pharm World Sci 2008;30:610-2.
• 10. Tortum F, Gür A. Investigation of the relationship between the PaO2/FiO2 ratio and Wells score in patients diagnosed with acute pulmonary embolism. Ann Med Res. 2023;30(2):226–230.
• 11. Kaya Z, Tuncez A, Tekinalp M, Karanfil M, Kayrak M, Özdemir K .Comprehensive Echocardiographic Evaluation In Acute Pulmonary Embolism.Selcuk Med J 2013;29(4): 172-176.
• 12. Khandait H, Harkut P, Khandait V, Bang V. Acute pulmonary embolism: Diagnosis and management. Indian Heart J. 2023 Sep-Oct;75(5):335-342. doi: 10.1016/j.ihj.2023.05.007.