USE OF HIGH-DOSE OF UROKINASE DURING CARDIOPULMONARY RESUSCITATION FOR CLINICALLY SUSPECTED MASSIVE PULMONARY EMBOLISM.

Year 2019, Volume: 10 Issue: 1 , 17 - 20 , 01.01.2019

Luis Chiscano Camon Juan Carlos Ruiz Rodriguez Laura Dono Anselmo Adolf Ruiz Sanmartin

https://doi.org/10.33706/jemcr.550556

Cited By: 1

https://izlik.org/JA43KR48ML

Abstract

Introduction: We are presenting
6 patients who suffered a cardiac arrest (CA) for suspected pulmonary embolism.
Before establishing a definitive diagnosis, advanced life support (ALS)
algorithm was initiated. Urokinase dosed as 15.000 UI/kg (weight) was
administered initially, followed by 4.400 UI/Kg for 12 hours as a continuous
intravenous perfusion. Two patients presented absolute contraindications for fibrinolytic
therapy, however only one patient presented a major hemorrhagic complication.
Global mortality rate was 83%.

Case report: We present 6 cases
of patients with CA due to MPE
who were treated with high doses of urokinase during cardiopulmonary resuscitation
and later admitted to the Intensive Care Unit (ICU).

Conclusion: Our observations suggest that the clinical suspected MPE with CA can also be
one of the recommended applications of thrombolysis with high-dose bolus
injection of thrombolytic with efficacy.

Keywords

cardiac arrest , cardiopulmonary resuscitation , pulmonary embolism , reperfusion

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