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A Rare Cause of Rhabdomiyolysis:Sildenafil

Year 2019, Volume: 10 Issue: 4, 98 - 100, 01.10.2019
https://doi.org/10.33706/jemcr.508406

Abstract

INTRODUCTION



 



Rhabdomyolysis is a syndrome characterized by muscle necrosis
and the release of
intracellular muscle components into the bloodstream.



 



CASE
REPORT



 



A
29-year-old male patient presented to the emergency department complaining of
nausea, vomiting and widespread body pain. Physical examination of the agitated
patient who did not want to talk was as followed; Vitals: BP: 115/50, Pulse:
85, Sa02: 95. The patient was conscious, oriented
, cooperative and his GCS was 15. Biochemical values
​​in laboratory tests; AST: 224, ALT: 183, LDH: 1273, CK: 33639, and drawn
arterial blood gas were determined as follows: pH: 7.45, hHCO3:18.7, lactate:
2.4. All other laboratory tests were normal. An ECG was performed and it showed
sinus tachycardia. When anamnesis was deepened, he stated that he used S
ildenafil and alcohol 24 hours
before and just 3 hours before his admission to the hospital. Patient informed
us that there was no coitus. In the follow-up, the patient who was given
hydration and sodium bicarbonate treatment did not develop dialysis necessity,
his biochemical values ​​showed a rapid decrease of CK level 24000-11000-5000
and the patient was discharged because of the decline of all  his complaints.



DISCUSSION




Rhabdomyolysis is a syndrome characterized by
muscle necrosis and the release of
intracellular muscle components into the
bloodstream. The true incidence of Sildenafil-related renal matters is unknown,
since the post-marketing data are very limited. More cases can be detected as
the number of prescription of Sildenafil increases.



 



 

CONCLUSİON

 

Even in patients with nonspecific symptoms, anamnesis (drug use, etc.) should be deepened. Physician awareness is important to prevent possible toxicities and systemic dysfunctions that may be caused by them.

References

  • 1. Melli G, Chaudhry V, Cornblath DR, Rhabdomyolysis: an evaluation of 475 hospitalized patients, Medicine (Baltimore), 2005;84(6):377-85.
  • 2. Haas CE, Magram Y, Mishra A, Rhabdomyolysis and acute renal failure following an ethanol and diphenhidramine overdose. Ann Pharmacother, 2003;37(4):538-42
  • 3. Saatcioglu Ö, Yıldız B S, Gökçe E, Tomruk N B, Rhabdomyolysis, Alcohol Related Rhabdomyolysis and Acute Renal Failure, Journal of Anatolian Clinical Research2010;4 /1:70-79.
  • 4.Mohey V, Singh M, Puri N, Kaur T, Pathak D, Singh AP, Sildenafil obviates ischemia-reperfusion injury–induced acute kidney injury through peroxisome proliferator–activated receptor γ agonism in rats, Journal of Surgical Research 2016;201(1):69-75.
  • 5.Bakota E L, Kelly AT, Walterscheid JP, Phatak D R, A Case Report of Fatal Desmethyl Carbodenafil Toxicity, Journal of Analytical Toxicology, 2017 Apr 1;41(3):250-255.
  • 6. Molehin O R, Adeyanju A A, Adefegha A S, Aina O, Afolabi B, Olowoyeye A, Oyediran J A, Olediran O R, Sildenafil, a phosphodiesterase-5 inhibitor, offers protection against carbon tetrachloride-induced hepatotoxicity in rat, Journal of Basic and Clinical Physiology and Pharmacology, 2018;29(1):29-35.
  • 7.Pennisi G, Vacante M, Russo C, Malaguarnera M, Rhabdomyolysis induced by rosuvastatin and sildenafil, South Medical Journal, 2010 Oct;103(10):1052-4.
  • 8.Oh DJ, Sildenafil overdose can cause rhabdomyolysis and subjective visual perception changes., Nephrology (Carlton). 2014 Apr;19(4):258.
Year 2019, Volume: 10 Issue: 4, 98 - 100, 01.10.2019
https://doi.org/10.33706/jemcr.508406

Abstract

References

  • 1. Melli G, Chaudhry V, Cornblath DR, Rhabdomyolysis: an evaluation of 475 hospitalized patients, Medicine (Baltimore), 2005;84(6):377-85.
  • 2. Haas CE, Magram Y, Mishra A, Rhabdomyolysis and acute renal failure following an ethanol and diphenhidramine overdose. Ann Pharmacother, 2003;37(4):538-42
  • 3. Saatcioglu Ö, Yıldız B S, Gökçe E, Tomruk N B, Rhabdomyolysis, Alcohol Related Rhabdomyolysis and Acute Renal Failure, Journal of Anatolian Clinical Research2010;4 /1:70-79.
  • 4.Mohey V, Singh M, Puri N, Kaur T, Pathak D, Singh AP, Sildenafil obviates ischemia-reperfusion injury–induced acute kidney injury through peroxisome proliferator–activated receptor γ agonism in rats, Journal of Surgical Research 2016;201(1):69-75.
  • 5.Bakota E L, Kelly AT, Walterscheid JP, Phatak D R, A Case Report of Fatal Desmethyl Carbodenafil Toxicity, Journal of Analytical Toxicology, 2017 Apr 1;41(3):250-255.
  • 6. Molehin O R, Adeyanju A A, Adefegha A S, Aina O, Afolabi B, Olowoyeye A, Oyediran J A, Olediran O R, Sildenafil, a phosphodiesterase-5 inhibitor, offers protection against carbon tetrachloride-induced hepatotoxicity in rat, Journal of Basic and Clinical Physiology and Pharmacology, 2018;29(1):29-35.
  • 7.Pennisi G, Vacante M, Russo C, Malaguarnera M, Rhabdomyolysis induced by rosuvastatin and sildenafil, South Medical Journal, 2010 Oct;103(10):1052-4.
  • 8.Oh DJ, Sildenafil overdose can cause rhabdomyolysis and subjective visual perception changes., Nephrology (Carlton). 2014 Apr;19(4):258.
There are 8 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Case Report
Authors

Selma Şimşek This is me 0000-0002-7585-6757

Büşra İhtiyar 0000-0003-2830-9782

Hatice Şeyma Akça 0000-0003-2823-9577

Kamil Kokulu 0000-0002-6132-0898

Serkan Emre Eroğlu 0000-0002-3183-3713

Publication Date October 1, 2019
Submission Date January 4, 2019
Published in Issue Year 2019 Volume: 10 Issue: 4

Cite

APA Şimşek, S., İhtiyar, B., Akça, H. Ş., Kokulu, K., et al. (2019). A Rare Cause of Rhabdomiyolysis:Sildenafil. Journal of Emergency Medicine Case Reports, 10(4), 98-100. https://doi.org/10.33706/jemcr.508406
AMA Şimşek S, İhtiyar B, Akça HŞ, Kokulu K, Eroğlu SE. A Rare Cause of Rhabdomiyolysis:Sildenafil. Journal of Emergency Medicine Case Reports. October 2019;10(4):98-100. doi:10.33706/jemcr.508406
Chicago Şimşek, Selma, Büşra İhtiyar, Hatice Şeyma Akça, Kamil Kokulu, and Serkan Emre Eroğlu. “A Rare Cause of Rhabdomiyolysis:Sildenafil”. Journal of Emergency Medicine Case Reports 10, no. 4 (October 2019): 98-100. https://doi.org/10.33706/jemcr.508406.
EndNote Şimşek S, İhtiyar B, Akça HŞ, Kokulu K, Eroğlu SE (October 1, 2019) A Rare Cause of Rhabdomiyolysis:Sildenafil. Journal of Emergency Medicine Case Reports 10 4 98–100.
IEEE S. Şimşek, B. İhtiyar, H. Ş. Akça, K. Kokulu, and S. E. Eroğlu, “A Rare Cause of Rhabdomiyolysis:Sildenafil”, Journal of Emergency Medicine Case Reports, vol. 10, no. 4, pp. 98–100, 2019, doi: 10.33706/jemcr.508406.
ISNAD Şimşek, Selma et al. “A Rare Cause of Rhabdomiyolysis:Sildenafil”. Journal of Emergency Medicine Case Reports 10/4 (October 2019), 98-100. https://doi.org/10.33706/jemcr.508406.
JAMA Şimşek S, İhtiyar B, Akça HŞ, Kokulu K, Eroğlu SE. A Rare Cause of Rhabdomiyolysis:Sildenafil. Journal of Emergency Medicine Case Reports. 2019;10:98–100.
MLA Şimşek, Selma et al. “A Rare Cause of Rhabdomiyolysis:Sildenafil”. Journal of Emergency Medicine Case Reports, vol. 10, no. 4, 2019, pp. 98-100, doi:10.33706/jemcr.508406.
Vancouver Şimşek S, İhtiyar B, Akça HŞ, Kokulu K, Eroğlu SE. A Rare Cause of Rhabdomiyolysis:Sildenafil. Journal of Emergency Medicine Case Reports. 2019;10(4):98-100.