DEFINITION OF VIBRATION EFFECT ON BONE HEALING

Abstract

Traumatic incidents, which can be accounted in daily life, may be occur bone fractures. As well as, controlled surgical implant plantation procedure causes same situation. Long healing time of bone causes serious health and comfort problems. Long healing time increases treatment cost, also causes uncomfortable life event for patient. Further, Serious working ability loss occurred due to mobility losses. If this mobility loss progression has been a matter of health problem in daily life, rehabilitation clinics work load increment has challenged to society. These points show to humanity the condition which is a serious burden to patient and society. Hence, potential treatment method; small magnitude-high frequency vibration affectivity has been studied with engineering discipline perspective. According to this path way, dynamic characteristics of sawbone femur has been studied with using Modal Analysis Technique. Damper coefficient, natural frequency has been obtained with various boundary conditions and their effects on healing process has been demonstrated. With study, also, effect of excitation location on bones dynamic behavior has been questioned

Keywords

• Bone Healing
• Remodelling
• Vibration
• Modal Analysis
• Sawbone Femur
• Dynamic Characteristics

TİTREŞİMİN KEMİK İYİLEŞMESİNE ETKİSİNİN BELİRLENMESİ

Abstract

Günümüzde yaşanan birçok travmatik olay kemik hasarlarına neden olmaktadır. Ameliyatlarda İmplant yerleştirilmesi sırasında oluşan kontrollü kemik hasarlarında da benzer durum ile karşılaşılabilmektedir. Her iki durumda kemik rejenerasyonunun uzun olması ciddi konfor ve sağlık problemlerine neden olmaktadır. Uzun iyileşme süreleri tedavi masraflarını arttırmakta, hastanın konforsuz bir süre geçirmesine sebep olmaktadır. Ayrıca mobilitenin büyük oranda azalmasına bağlı olarak ciddi iş kayıpları meydana gelmektedir. Mobilite kaybının ilerlemesi, fizik rehabilitasyon kliniğinin de iş yükünün artmasına sebep olmaktadır. Bu durum ele alındığında görülmektedir ki, kemiklerin iyileşme süreci hem bireye, hem de topluma karşı ekonomik ve sosyal yönden büyük bir yük oluşturmaktadır. Bu nedenle, günümüzde potansiyeli ortaya konan, küçük genlikli-yüksek frekanslı titreşimlerin etkinliği mühendislik disiplini çerçevesinde değerlendirilmiştir. Bu çerçevede sawbone femura ait dinamik karakteristikler modal analiz ile araştırılmıştır. Farklı bağ koşullarındaki frekans ve sönüm karakteristikleri ve bunların kemik iyileşmesine etkileri çalışma neticesinde ortaya konmuştur. Çalışmada ayrıca, farklı titreşim değerlerinde kemiğin mekanik cevabının ne olacağı sorusuna da cevap aranmaktadır.

Keywords

• Kemik İyileşmesi
• Remodelling
• Titreşim
• Modal Analiz
• Sawbone Femur
• Dinamik Karakteristik

References

1. Altun İ., 2011. “Alt Ekstremite Kısalıklarında İlizarov Eksternal Fiksatör ile Uzatma Sonuçları”. Uzmanlık Tezi, 111s, Adana
2. Antonia Torcasio A. Katharina Jähn K., Guyse M., Spaepen P., Tami A.E., Sloten J.V., Jones D.B., Stoddart M.J., Lenthe G.H., 2012. “Trabecular Bone Adaptation To Low-Magnitude High-Frequency Loading At Micro- Gravity”. 18th Congress of the European Society of Biomechanics. 1-4 Temmuz 2012, Lizbon, Portekiz, 531
3. Awad H.A., Keefe R.J., Lee C.H., Mao J.J., 2014. “Bone Tissue Engineering: Clinical Challenges and Emergent Advances in Orthopedic and Craniofacial Surgery, Principles of Tissue Engineering”, Elsevier, 4. Baskı, s1733-1743, ABD
4. Blecha L.D., Rakotomanana L., Razafimahery F., Terrier A., Pioletti D.P. 2010., “Mechanical Interaction Between Cells And Fluid For Bone Tissue Engineering Scaffold: Modulation Of The Interfacial Shear Stress”, Journal of Biomechanics, 43, 933-937
5. Brånemark R., Brånemark P.I., Rydevik B., Myers R.R., 2001. “Osseointegration In Skeletal Reconstruction And
6. Research and Development, 38(2), 1-8 of
7. Rehabilitation Cairns J. N., Pearcy M.J., Smeathers J., Clayton J.A. 2013. “Ability Of Modal Analysis To Detect Osseointegration Of Implants In Transfemoral Amputees: A Physical Model Study”, Medical & Biological Engineering & Computing, 51, 39-47
8. Chen J.H., Liu C., You L., Simmons C.A., 2010. “Boning Upon Wolff’s Law: Mechanical Regulation Of The Cells That Make And Maintain Bone”. Journal of Biomechanics 43,108–118

9. Hong P., 2011. “A Clinical Narrative Review Of Mandibular Distraction Osteogenesis In Neonates With Pierre Robin Sequence”. International Journal of Pediatric Otorhinolaryngology. 75, 985–991.
10. Ignatius A., Blessing H., Liedert A., Schmidt C., Neidlinger-Wilke C., Kaspar D., Friemert B., Claes L. 2005. “Tissue Engineering Of Bone: Effects Of Mechanical Strain On Osteoblastic Cells In Type Icollagen Matrices”, Biomaterials, 26, 311-318 International
11. “Epidemiology, Costs And Burden Of Osteoporosis In Asia”, 60s Foundation
12. 200 International
13. “Capture the Fracture: A Global Campaign to Break the Fragility Fracture Cycle”, 28s Foundation
14. 20 Judex S., Lei X., Han D., Rubin C. 2007. “Low-Magnitude Mechanical Signals That Stimulate Bone Formation In The Ovariectomized Rat Are Dependent On The Applied Frequency But Not On The Strain Magnitude”, Journal of Biomechanics 40, 1333–1339
15. Kameo Y., Adachi T., Hojo M. 2011. “Effects Of Loading Frequency On The Functional Adaptation Of Trabeculae
16. Simulation”, Journal of the Mechanical Behavior of Biomedical Materials, 4, 900-908
17. Remodeling Kanazawa I., Yamaguchi T., Tada Y., Yamauchi M., Yano S., Sugimoto T., 2011 “Serum Osteocalcin Level Is Positively Associated With Insulin Sensitivity And Secretion In Patients With Type 2 Diabetes”. Bone. 48, 720–725
18. Karsenty G., Ferron M., 2012. “The Contribution Of Bone To Whole-Organism Physiology”. Nature. 481, 314-320
19. Kloss F.R., Gassner R., 2006. “Bone And Aging: Effects On The Maxillofacial Skeleton”, Experimental Gerontology 41, 123–129
20. Kozlovskaya I.B., Sayenko I.V., Miller T.F., Khusnutdinova D.R., Melnik K.A.,
21. Morris E.C., 2012. “Why are So Many Ion Channels Mechanosensitive?”. Cell Physiology Sourcebook. 493- 505, 4. Baskı, ABD
22. Popov D.V., Vinogradova O.L., Yarmanova E.N., Tomilovskaya E.S., 2007. “Erratum To: New Approaches To Countermeasures Of The Negative Effects Of Micro-Gravity In Long-Term Space Flights [Acta Astronautica 59 (2006) 13–19]”. Acta Astronautica. 60, 783 – 789
23. Prisby R.D., Lafage-Proust M.H., Malaval L., Belli A., Vico L., 2008. “Effects Of Whole Body Vibration On The Skeleton And Other Organ Systems In Man And Animal Models: What We Know And What We Need To Know”, Ageing Research Reviews, 7, 319–329
24. Sandino C., Planell J.A., Lacroix D. 2008. “A Finite Element Study Of Mechanical Stimuli In Scaffolds For Bone Tissue Engineering”, Journal of Biomechanics, 41, 1005–1014
25. Shao F., Xu W., Crocombe A., Ewins D. 2007. “Natural Frequency Analysis of Osseointegration for Trans- femoral Implant”, Annals of Biomedical Engineering, 35(5), 817-824
26. Tanaka S.M., Li J., Duncan R.L., Yokota H., Burr D.B., Charles H.T., 2003, “Effects Of Broad Frequency Vibration On Cultured Osteoblasts”, Journal of Biomechanics, 36, 73-80
27. Thompson W.R., Rubin C.T., Rubin J. 2012. “Mechanical Regulation Of Signaling Pathways In Bone”, Gene, 503,179–193
28. Thrailkill K.M. , Lumpkin C.K. , Bunn ,Jr. R. C., Kemp S.F., and Fowlkes J.L., 2005. “Is Insulin An Anabolic Agent In Bone? Dissecting The Diabetic Bone For Clues”. Am. J. Physiol. Endocrinol. Metab. 289, 735–745
29. Weinbaum S., Cowin S.C., Zeng Y., 1994. “A Model for the Excitation of Osteocytes by Mechanical Loading- Induced Bone Fluid Shear Stresses”. Journal of Biomechanics. 27(3) 339-360
30. WHO, Diabetes, 2014.
31. http://www.who.int/mediacentre/factsheets/fs312/ en/
32. Zadpoor A.A. 2013. “Open Forward And Inverse Problems In Theoretical Modeling Of Bone Tissue Adaptation”, Journal of the Mechanical Behavior of Biomedical Materials, 27, 249-261
33. Zhang X., Torcasio A., Vandamme K., Ogawa T., Lenthe G.H., Naert I., Duyck J., “Enhancement of Implant Osseointegration by High-Frequency Low-Magnitude Loading,
34. http://www.plosone.org/article/info%3Adoi%2F10. 1371%2Fjournal.pone.0040488, Son erişim tarihi: 11 Nisan 2014 Plos one,