QUANTITATION OF ACETAMINOPHEN IN PHARMACEUTICAL FORMULATIONS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

Sinan Süzen; Cemal Akay; Şenol Tartılmış; Serdar Erdöl R.; Atilla Önal; Şemsettin Cevheroğlu

doi:10.1501/Eczfak_0000000325

: YÜKSEK BASINÇLI SIVI KROMATOGRAFİSİ KULLANILARAK FARMASÖTÎK FORMÜLASYONLARDA ASETAMİNOFEN

Year 1998, Volume: 27 Issue: 2, 93 - 100, 01.12.1998

Sinan Süzen Cemal Akay Şenol Tartılmış Serdar Erdöl R. Atilla Önal Şemsettin Cevheroğlu

https://doi.org/10.1501/Eczfak_0000000325

https://izlik.org/JA82LK56LG

Abstract

Bu çalışmada asetaminofenin kantitatif tayini için ters fazlı yüksek basınçlı sıvı kromatografisi yöntemi geliştirilmiştir. C18stasyoner fazda, 1.78 ml/dak akış hızındaki metanolsu (1/2, v/v) karışımı kullanılarak 193.3 nm'de tayin yapılmıştır. Sülfametoksazolün internal standart olarak kullanıldığı analiz 5 dakika içinde tamamlanmaktadır. Metod iyi bir linearite, kesinlik ve tekrarlanabilirlik göstermektedir. Önerilen metod, asetaminofenin tablet ve şuruptaki analizine başarı ile uygulanmıştır

Keywords

Asetaminofen , parasetamol , yüksek basınçlı sıvı kromatografisi , tablet , şurup

QUANTITATION OF ACETAMINOPHEN IN PHARMACEUTICAL FORMULATIONS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

Year 1998, Volume: 27 Issue: 2, 93 - 100, 01.12.1998

Sinan Süzen Cemal Akay Şenol Tartılmış Serdar Erdöl R. Atilla Önal Şemsettin Cevheroğlu

https://doi.org/10.1501/Eczfak_0000000325

https://izlik.org/JA82LK56LG

Abstract

A reversed-phase high-performance liquid chromatographic method has heen developed for the determination of acetaminophen in pharmaceutical formulations. A C18 stationary phase is used with a methanol-water (1/2, v/v) mixture at the flow rate of 1.78 ml/min with the spectrophotometric detection at 193.3 nm. Sulphamethoxazole is used as an internal standard and analysis is completed within 5 minutes. The method showed good linearity, precision and reproducibility. The proposed method was successfully applied to the determination of acetaminophen in tablet and syrup

Keywords

Acetaminophen , paracetamol , high-pressure liquid chromatography , tablet , syrup

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Details

Other ID	JA59HY97CD
Authors	Sinan Süzen This is me Cemal Akay This is me Şenol Tartılmış This is me Serdar Erdöl R. This is me Atilla Önal This is me Şemsettin Cevheroğlu This is me
Submission Date	December 1, 1998
Publication Date	December 1, 1998
DOI	https://doi.org/10.1501/Eczfak_0000000325
IZ	https://izlik.org/JA82LK56LG
Published in Issue	Year 1998 Volume: 27 Issue: 2

Cite

APA	Süzen, S., Akay, C., Tartılmış, Ş., Erdöl R., S., Önal, A., & Cevheroğlu, Ş. (1998). QUANTITATION OF ACETAMINOPHEN IN PHARMACEUTICAL FORMULATIONS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY. Journal of Faculty of Pharmacy of Ankara University, 27(2), 93-100. https://doi.org/10.1501/Eczfak_0000000325
AMA	1.Süzen S, Akay C, Tartılmış Ş, Erdöl R. S, Önal A, Cevheroğlu Ş. QUANTITATION OF ACETAMINOPHEN IN PHARMACEUTICAL FORMULATIONS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY. J. Fac. Pharm. Ankara. 1998;27(2):93-100. doi:10.1501/Eczfak_0000000325
Chicago	Süzen, Sinan, Cemal Akay, Şenol Tartılmış, Serdar Erdöl R., Atilla Önal, and Şemsettin Cevheroğlu. 1998. “QUANTITATION OF ACETAMINOPHEN IN PHARMACEUTICAL FORMULATIONS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY”. Journal of Faculty of Pharmacy of Ankara University 27 (2): 93-100. https://doi.org/10.1501/Eczfak_0000000325.
EndNote	Süzen S, Akay C, Tartılmış Ş, Erdöl R. S, Önal A, Cevheroğlu Ş (December 1, 1998) QUANTITATION OF ACETAMINOPHEN IN PHARMACEUTICAL FORMULATIONS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY. Journal of Faculty of Pharmacy of Ankara University 27 2 93–100.
IEEE	[1]S. Süzen, C. Akay, Ş. Tartılmış, S. Erdöl R., A. Önal, and Ş. Cevheroğlu, “QUANTITATION OF ACETAMINOPHEN IN PHARMACEUTICAL FORMULATIONS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY”, J. Fac. Pharm. Ankara, vol. 27, no. 2, pp. 93–100, Dec. 1998, doi: 10.1501/Eczfak_0000000325.
ISNAD	Süzen, Sinan - Akay, Cemal - Tartılmış, Şenol - Erdöl R., Serdar - Önal, Atilla - Cevheroğlu, Şemsettin. “QUANTITATION OF ACETAMINOPHEN IN PHARMACEUTICAL FORMULATIONS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY”. Journal of Faculty of Pharmacy of Ankara University 27/2 (December 1, 1998): 93-100. https://doi.org/10.1501/Eczfak_0000000325.
JAMA	1.Süzen S, Akay C, Tartılmış Ş, Erdöl R. S, Önal A, Cevheroğlu Ş. QUANTITATION OF ACETAMINOPHEN IN PHARMACEUTICAL FORMULATIONS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY. J. Fac. Pharm. Ankara. 1998;27:93–100.
MLA	Süzen, Sinan, et al. “QUANTITATION OF ACETAMINOPHEN IN PHARMACEUTICAL FORMULATIONS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY”. Journal of Faculty of Pharmacy of Ankara University, vol. 27, no. 2, Dec. 1998, pp. 93-100, doi:10.1501/Eczfak_0000000325.
Vancouver	1.Süzen S, Akay C, Tartılmış Ş, Erdöl R. S, Önal A, Cevheroğlu Ş. QUANTITATION OF ACETAMINOPHEN IN PHARMACEUTICAL FORMULATIONS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY. J. Fac. Pharm. Ankara [Internet]. 1998 Dec. 1;27(2):93-100. Available from: https://izlik.org/JA82LK56LG

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.