NANOTHERANOSTICS

Year 2021, , 131 - 155, 18.01.2021

Meliha Ekinci , Derya İlem-özdemir

https://doi.org/10.33483/jfpau.717067

Cited By: 2

Abstract

Objective: In recent years, significant advances have been made in early diagnosis and treatment of diseases, thanks to advances in nanotechnology. With the birth of the concept of “theranostic”, a concept that combines diagnostic imaging methods with therapeutic methods, cancer nanotherapy has started to rise rapidly. In this review, it is aimed to review the recent studies on these subjects by giving information about the theranostic concept, cancer nanotherapy, drug and gene delivery systems, nanoprobes, nanosensors, personalized therapy, and active and passive targeting.

Result and Discussion: The use of nanostructures carrying various targeted drugs, genes and imaging agents has provided new possibilities for personalized medicine. In medicine, by overcoming biological barriers in the body with nanoscale drug delivery systems, targeted diagnosis with imaging systems and treatment with theranostics are provided. We believe that the use of nanoteranostic in medicine, which provides early diagnosis and treatment of cancer, which is the main cause of death in the world, will take up a wider place day by day.

Keywords

Drug delivery systems, personalized medicine, nanotechnology, theranostics

NANOTERANOSTİKLER

Abstract

Amaç: Son yıllarda, nanoteknolojideki gelişmeler sayesinde hastalıkların erken teşhis ve tedavisinde önemli ilerlemeler kaydedilmektedir. Tanısal görüntüleme yöntemleriyle tedavi yöntemlerini birleştiren bir kavram olan “teranostik” kavramının doğmasıyla kanser nanotıbbı hızlı bir yükselişe geçmiştir. Bu derlemede, teranostik kavramı, kanser nanotıbbı, ilaç ve gen taşıyıcı sistem çeşitleri, nanogörüntüleme yöntemleri, nanoproblar, nanosensörler, kişiselleştirilmiş tedavi ve aktif ve pasif hedeflendirme ile ilgili bilgiler verilerek, son yıllarda bu konularda yapılmış olan çalışmaların gözden geçirilmesi amaçlanmıştır.

Sonuç ve Tartışma: Hedeflendirilmiş çeşitli ilaç, gen ve görüntüleme maddelerini taşıyan nanoyapıların kullanılması kişiselleştirilmiş tedaviye yeni olanaklar sağlamıştır. Tıpta nanoboyutlu ilaç taşıyıcı sistemler ile vücuttaki biyolojik bariyerler aşılarak, görüntüleme sistemleriyle hedefe yönelik teşhis ve teranostikler ile de tedavi sağlanmaktadır. Dünyada başlıca ölüm sebebi olan kanserin erken teşhisini ve tedavisini sağlayan nanoteranostiklerin tıpta kullanımının gün geçtikçe daha geniş bir yer kaplayacağı kanaatindeyiz.

Keywords

İlaç taşıyıcı sistemler, kişiselleştirilmiş tedavi, nanoteknoloji, radyofarmasötik, teranostik

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