The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.
Year 2003,
Volume: 32 Issue: 4, 231 - 241, 01.12.2003
Abstract
Bu çalışmada, vitamin E tedavisinin, diyabetik siçanlarda trakea reaktivitesindeki değişiklikler ve bazı biyokimyasal parametreler iizerindeki etkileri araştırılmıştır. Erkek siçanlar kontrol ve diyabetik olmak üzere rastgele iki gruba ayrılmıştır. Diyabet, tek doz streptozotosin enjeksiyonu (STZ; 60 mglkg i.p.) ile yapılmıştır. Sonrasında diyabetik sıçanların bir kısmına, vitamin E tedavisi uygulanmıştır. Vitamin E, standart laboratuvar yemine (DL-_ tocophenyl asetat 0.5 % w/w) katılarak, diyabet oluştuktan 8 hafta sonra 8 hafta süre ile verilmiştir. Diyabetik sıçanların Vitamin E ile tedavisi, diyabette artan plazma trigliserid ve tiyobarbitürik asit reaktif substans düzeylerini, hiperglisemi üzerine bir etkisi olmaksızın azaltmıştır. Vitamin E, diyabetik trakeada ise artmış asetilkolin (Ask) ve potasyum klorür(KCl) yanıtlarını düzeltmiştir. Bu çalışmanın sonuçları, vitamin E tedavisinin diyabetik sıçanlarda artan lipid peroksidasyonu ve trakea reaktivitesini düzelterek, diyabetik komplikasyonların tedavisinde yararlı etkileri olduğunu göstermektedir
THE EFFECTS OF VITAMIN E TREATMENT ON TRACHEAL REACTIVITY AND SOME BIOCHEMICAL PARAMETERS IN DIABETIC RATS
Abstract
The present study investigated the effect of vitamin E treatment on the alterations in reactivity of trachea and some biochemical parameters in diabetic rat. Rats were randomly divided into two groups: Control and diabetic. Diabetes was induced by a single dose injection of streptozotocin (STZ; 60 mglkg ;i.p.). Diabetic rats were divided into two groups as untreated and treated with vitamin E. Vitamin E was given as a high-vitamin E diet in the standard laboratory chow diet (DL-_ tocophenyl acetate 0.5 % w/w) for 8 weeks started 8- week after induction of diabetes. In Vitamin E treated diabetic rats, the increased plasma triglyceride and thiobarbituric reactive substance levels due to diabetes were reduced without any effect on hyperglycemia. Vitamin E significantly restored the increased contractile responses to acetylcholine (ACh) and potassium chloride (KCl) in diabetic trachea. It is concluded that vitamin E treatment restored increased lipid peroxidation and tracheal reactivity in diabetic rat thus Vitamin E treatment may have beneficial effect on diabetic complications
There are 0 citations in total.
Details
| Other ID | JA58UM97HY |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | December 1, 2003 |
| Submission Date | December 1, 2003 |
| Published in Issue | Year 2003 Volume: 32 Issue: 4 |