The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.
Year 1998,
Volume: 27 Issue: 2, 93 - 100, 01.12.1998
Abstract
Bu çalışmada asetaminofenin kantitatif tayini için ters fazlı yüksek basınçlı sıvı kromatografisi yöntemi geliştirilmiştir. C18stasyoner fazda, 1.78 ml/dak akış hızındaki metanolsu (1/2, v/v) karışımı kullanılarak 193.3 nm'de tayin yapılmıştır. Sülfametoksazolün internal standart olarak kullanıldığı analiz 5 dakika içinde tamamlanmaktadır. Metod iyi bir linearite, kesinlik ve tekrarlanabilirlik göstermektedir. Önerilen metod, asetaminofenin tablet ve şuruptaki analizine başarı ile uygulanmıştır
QUANTITATION OF ACETAMINOPHEN IN PHARMACEUTICAL FORMULATIONS USING HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
Abstract
A reversed-phase high-performance liquid chromatographic method has heen developed for the determination of acetaminophen in pharmaceutical formulations. A C18 stationary phase is used with a methanol-water (1/2, v/v) mixture at the flow rate of 1.78 ml/min with the spectrophotometric detection at 193.3 nm. Sulphamethoxazole is used as an internal standard and analysis is completed within 5 minutes. The method showed good linearity, precision and reproducibility. The proposed method was successfully applied to the determination of acetaminophen in tablet and syrup
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Details
| Other ID | JA59HY97CD |
|---|---|
| Authors | |
| Publication Date | December 1, 1998 |
| Submission Date | December 1, 1998 |
| Published in Issue | Year 1998 Volume: 27 Issue: 2 |