DENEY HAYVANLARINDA FERTİLİTE YÖNÜNDEN BİTKİSEL KAYNAKLI ANTİOKSİDANLARIN KULLANIMI

Serdal Kurt

doi:10.33483/jfpau.472016

Review

DENEY HAYVANLARINDA FERTİLİTE YÖNÜNDEN BİTKİSEL KAYNAKLI ANTİOKSİDANLARIN KULLANIMI

Year 2019, Volume: 43 Issue: 2, 197 - 208, 01.06.2019

Serdal Kurt

https://doi.org/10.33483/jfpau.472016

Cited By: 1

Abstract

Amaç: Deney hayvanlarında bitkisel kaynaklı antioksidanların kullanımının
fertilite üzerine etkisini araştırmak amaçlandı.

Gereç ve Yöntem: Bu alanda yapılmış bilimsel çalışmalar
incelendi. Elde edilen bilimsel bilgiler doğrultusunda antioksidan içerikli
bazı bitkilerin deney hayvanlarında fertilite parametrelerine etkileri
derlenmeye çalışıldı. Antioksidanlar, oksidasyonu engelleyen maddeler olarak
tanımlanmaktadır. En yaygın antioksidan maddeler arasında olan A vitamini, C
vitamini, E vitamini ve fenolik bileşiklerin temel kaynağı bitkilerdir.
Antioksidan maddeler, hücresel metabolizma ile mitokondrilerde enerji
üretilmesi sırasında yan ürün olarak açığa çıkan serbest radikalleri nötraliz
ederek zararlı etkilerine karşı vücudu korurlar. Ancak açığa çıkan serbest
radikaller antioksidan maddelerin detoksifiye etme kapasitesini aşarsa
oksidatif stres meydana gelerek hücrelerde Dezoksiribonükleik asit (DNA),
protein ve lipit hasarı ile malignant hücre gelişimine neden olabilir. Dolayısı
ile oksidatif stresin organ ve dokularda hastalık meydana getirmesinin yanında
eşey hücrelerde oluşturduğu fonksiyon bozuklukları ile de reprodüktif sorunlara
yol açmaktadırlar.

Sonuç ve
Tartışma: Tavşan, sıçan ve fareler üzerinde
yapılan çalışmalarda nötralize edilemeyen serbest radikallerin fertilite
sorunlarına yol açtığı tespit edilmiştir. Bu alanda yapılan çalışmaların
sonucunda deney hayvanlarında bitkisel kaynaklı antioksidanların kullanımın
sperm, semen, oosit ve embriyo gibi fertilite parametrelerini iyileştirdiği
saptanmıştır.

Keywords

bitkisel kaynaklı antioksidan, deney hayvanı, fertilite, oksidatif stres

References

1. Hanukoglu, I. (2006). Antioxidant protective mechanisms against reactive oxygen species (ROS) generated by mitochondrial P450 systems in steroidogenic cells. Drug metabolism reviews, 38(1-2), 171-196.
2. Jeeva, J. S., Sunitha, J., Ananthalakshmi, R., Rajkumari, S., Ramesh, M., & Krishnan, R. (2015). Enzymatic antioxidants and its role in oral diseases. Journal of pharmacy & bioallied sciences, 7(Suppl 2), S331.
3. Sen, S., Chakraborty, R., Sridhar, C., Reddy, Y. S. R., & De, B. (2010). Free radicals, antioxidants, diseases and phytomedicines: current status and future prospect. International Journal of Pharmaceutical Sciences Review and Research, 3(1), 91-100.
4. Sen, S., & Chakraborty, R. (2011). The role of antioxidants in human health. Oxidative stress: diagnostics, prevention, and therapy, 1083, 1-37.
5. Luximon-Ramma, A., Bahorun, T., Soobrattee, M. A., & Aruoma, O. I. (2002). Antioxidant activities of phenolic, proanthocyanidin, and flavonoid components in extracts of Cassia fistula. Journal of Agricultural and Food Chemistry, 50(18), 5042-5047.
6. Al Jothery, A. H., Vaanholt, L. M., Mody, N., Arnous, A., Lykkesfeldt, J., Bünger, L., ... & Speakman, J. R. (2016). Oxidative costs of reproduction in mouse strains selected for different levels of food intake and which differ in reproductive performance. Scientific reports, 6, 36353.
7. Hanafi, E. M., Raouf, A. A., Kassem, S. S., Abdel-Kader, M. M., & Elkadrawy, H. H. (2010). A novel herbal remedy to alleviate drawbacks of heat stress in rats with special references to some reproductive and molecular alterations. Global J. Biotechnol. Biochem, 5(3), 145-52.
8. Storey, K. B. (1996). Oxidative stress: animal adaptations in nature. Brazilian Journal of Medical and Biological Research, 29, 1715-1733.
9. Ornoy, A. (2007). Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy. Reproductive toxicology, 24(1), 31-41.
10. Miller, J. K., Brzezinska-Slebodzinska, E., & Madsen, F. C. (1993). Oxidative stress, antioxidants, and animal function. Journal of dairy science, 76(9), 2812-2823.
11. Puppel, K., Kapusta, A., & Kuczyńska, B. (2015). The etiology of oxidative stress in the various species of animals, a review. Journal of the Science of Food and Agriculture, 95(11), 2179-2184.
12. Metcalfe, N. B., & Alonso‐Alvarez, C. (2010). Oxidative stress as a life‐history constraint: the role of reactive oxygen species in shaping phenotypes from conception to death. Functional Ecology, 24(5), 984-996.
13. Zhong, R. Z., & Zhou, D. W. (2013). Oxidative stress and role of natural plant derived antioxidants in animal reproduction. Journal of Integrative Agriculture, 12(10), 1826-1838.
14. Melov, S., Schneider, J. A., Day, B. J., Hinerfeld, D., Coskun, P., Mirra, S. S., ... & Wallace, D. C. (1998). A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. Nature genetics, 18(2), 159.
15. Rizzo, A., Roscino, M. T., Binetti, F., & Sciorsci, R. L. (2012). Roles of reactive oxygen species in female reproduction. Reproduction in Domestic Animals, 47(2), 344-352.
16. Agarwal, A., & Allamaneni, S. S. (2004). Role of free radicals in female reproductive diseases and assisted reproduction. Reproductive biomedicine online, 9(3), 338-347.
17. Stier, A., Reichert, S., Massemin, S., Bize, P., & Criscuolo, F. (2012). Constraint and cost of oxidative stress on reproduction: correlative evidence in laboratory mice and review of the literature. Frontiers in zoology, 9(1), 37.
18. Walczak–Jedrzejowska, R., Wolski, J. K., & Slowikowska–Hilczer, J. (2013). The role of oxidative stress and antioxidants in male fertility. Central European journal of urology, 66(1), 60.
19. Agarwal, A., Aponte-Mellado, A., Premkumar, B. J., Shaman, A., & Gupta, S. (2012). The effects of oxidative stress on female reproduction: a review. Reproductive biology and endocrinology, 10(1), 49.
20. Aitken, R. J., & Baker, M. A. (2004). Oxidative stress and male reproductive biology. Reproduction, Fertility and development, 16(5), 581-588.
21. Aitken, R. J., & Roman, S. D. (2008). Antioxidant systems and oxidative stress in the testes. Oxidative medicine and cellular longevity, 1(1), 15-24.
22. Agarwal, A., Makker, K., & Sharma, R. (2008). Clinical relevance of oxidative stress in male factor infertility: an update. American journal of reproductive immunology, 59(1), 2-11.
23. Shrilatha, B. (2007). Early oxidative stress in testis and epididymal sperm in streptozotocin-induced diabetic mice: its progression and genotoxic consequences. Reproductive Toxicology, 23(4), 578-587.
24. Demyda, S., & Genero, E. (2011). Developmental competence of in vivo and in vitro matured oocytes: a review. Biotechnology and Molecular Biology Reviews, 6(7), 155-165.
25. El Mouatassim, S., Guerin, P., & Menezo, Y. (1999). Expression of genes encoding antioxidant enzymes in human and mouse oocytes during the final stages of maturation. Molecular Human Reproduction, 5(8), 720-725.
26. Agarwal, A., Gupta, S., & Sharma, R. K. (2005). Role of oxidative stress in female reproduction. Reproductive biology and endocrinology, 3(1), 28.
27. Wang, X., Falcone, T., Attaran, M., Goldberg, J. M., Agarwal, A., & Sharma, R. K. (2002). Vitamin C and Vitamin E supplementation reduce oxidative stress–induced embryo toxicity and improve the blastocyst development rate. Fertility and sterility, 78(6), 1272-1277.
28. Shahidi, F., Janitha, P. K., & Wanasundara, P. D. (1992). Phenolic antioxidants. Critical reviews in food science & nutrition, 32(1), 67-103.
29. Dai, J., & Mumper, R. J. (2010). Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules, 15(10), 7313-7352.
30. Khaki, A., Ouladsahebmadarek, E., Javadi, L., Farzadi, L., Fathiazad, F., & Nouri, M. (2011). Anti-oxidative effects of citro flavonoids on spermatogenesis in rat. African Journal of Pharmacy and Pharmacology, 5(6), 721-725.
31. Halenár, M., Tvrdá, E., Baldovská, S., Ondruška, Ľ., Massányi, P., & Kolesárová, A. In vitro Effects of Viscum album on the Functionality of Rabbit Spermatozoa. World Academy of Science, Engineering and Technology, International Journal of Biological, Biomolecular, Agricultural, Food and Biotechnological Engineering, 11(2), 108-112.
32. Khaki, A., Fathiazad, F., Ahmadi-Ashtiani, H. R., Rastgar, H., & Rezazadeh, S. (2009). Effects of Danae racemosa on Spermatogenesis in Rat. Journal of Medicinal Plants, 3(31), 87-92.
33. Zangeneh, F. Z., Minaee, B., Amirzargar, A., Ahangarpour, A., & Mousavizadeh, K. (2010). Effects of chamomile extract on biochemical and clinical parameters in a rat model of polycystic ovary syndrome. Journal of reproduction & infertility, 11(3), 169.
34. Ofem, O. E. (2014). Enhancement of some sex hormones concentrations by consumption of leaves extract of Viscum album (mistletoe) in rats. Asian Journal of Medical Sciences (E-ISSN 2091-0576; P-ISSN 2467-9100), 5(3), 87-90.
35. Ifeanyi, A. C., Yama, O. E., Ikechukwu, D. F., Adewale, O. A., Noronha, C. C., & Olugbenga, O. A. (2011). Effect of Momordica Charantia on estrous cycle of Sprague-Dawley rats. Pacific Journal of Medical Sciences, 8(1), 37-48.

USES OF PLANT-DERIVED ANTIOXIDANTS IN TERMS OF FERTILITY IN EXPERIMENTAL ANIMALS

Year 2019, Volume: 43 Issue: 2, 197 - 208, 01.06.2019

Serdal Kurt

https://doi.org/10.33483/jfpau.472016

Cited By: 1

Abstract

Objective: This study was aimed
to investigate the effect of using plant-derived antioxidants on fertility in
experimental animals.

Material and Method:
Scientific studies related to this study were investigated. In line with
information obtained, the effects of some antioxidant plants on fertility
parameters of experimental animals were reviewed.

Antioxidants are defined as substances
that inhibits oxidation. The most common antioxidant substances are vitamin A,
vitamin C, vitamin E and phenolic compounds. And also, their main origin are
the plants. Free radicals arise as byproduct during production of energy by
cellular metabolism in mitochondria. Antioxidants neutralize free radicals and
thus protect the body against the harmful effects of oxidants. If the free
radicals exceed detoxification capacity of antioxidant substances, oxidative
stress occurs. Oxidative stress can damage to cellular components such as
deoxyribonucleic acid (DNA), protein and lipids and leads to formation of
malignant cells. So, oxidative stress results in reproductive problems because
it induces functional disorders in sex cells, organs and tissues.

Result and Discussion: Studies on rabbits, mice, and rats have shown that
non-neutralized free radicals cause reproductive dysfunction In conclusion, it
was determined that the plant-derived antioxidants improve fertility parameters
such as sperm, semen, oocytes and embryos in the experimental animals.

Keywords

experimental animal, fertility, oxidative stress, plant-derived antioxidants

References

1. Hanukoglu, I. (2006). Antioxidant protective mechanisms against reactive oxygen species (ROS) generated by mitochondrial P450 systems in steroidogenic cells. Drug metabolism reviews, 38(1-2), 171-196.
2. Jeeva, J. S., Sunitha, J., Ananthalakshmi, R., Rajkumari, S., Ramesh, M., & Krishnan, R. (2015). Enzymatic antioxidants and its role in oral diseases. Journal of pharmacy & bioallied sciences, 7(Suppl 2), S331.
3. Sen, S., Chakraborty, R., Sridhar, C., Reddy, Y. S. R., & De, B. (2010). Free radicals, antioxidants, diseases and phytomedicines: current status and future prospect. International Journal of Pharmaceutical Sciences Review and Research, 3(1), 91-100.
4. Sen, S., & Chakraborty, R. (2011). The role of antioxidants in human health. Oxidative stress: diagnostics, prevention, and therapy, 1083, 1-37.
5. Luximon-Ramma, A., Bahorun, T., Soobrattee, M. A., & Aruoma, O. I. (2002). Antioxidant activities of phenolic, proanthocyanidin, and flavonoid components in extracts of Cassia fistula. Journal of Agricultural and Food Chemistry, 50(18), 5042-5047.
6. Al Jothery, A. H., Vaanholt, L. M., Mody, N., Arnous, A., Lykkesfeldt, J., Bünger, L., ... & Speakman, J. R. (2016). Oxidative costs of reproduction in mouse strains selected for different levels of food intake and which differ in reproductive performance. Scientific reports, 6, 36353.
7. Hanafi, E. M., Raouf, A. A., Kassem, S. S., Abdel-Kader, M. M., & Elkadrawy, H. H. (2010). A novel herbal remedy to alleviate drawbacks of heat stress in rats with special references to some reproductive and molecular alterations. Global J. Biotechnol. Biochem, 5(3), 145-52.
8. Storey, K. B. (1996). Oxidative stress: animal adaptations in nature. Brazilian Journal of Medical and Biological Research, 29, 1715-1733.
9. Ornoy, A. (2007). Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy. Reproductive toxicology, 24(1), 31-41.
10. Miller, J. K., Brzezinska-Slebodzinska, E., & Madsen, F. C. (1993). Oxidative stress, antioxidants, and animal function. Journal of dairy science, 76(9), 2812-2823.
11. Puppel, K., Kapusta, A., & Kuczyńska, B. (2015). The etiology of oxidative stress in the various species of animals, a review. Journal of the Science of Food and Agriculture, 95(11), 2179-2184.
12. Metcalfe, N. B., & Alonso‐Alvarez, C. (2010). Oxidative stress as a life‐history constraint: the role of reactive oxygen species in shaping phenotypes from conception to death. Functional Ecology, 24(5), 984-996.
13. Zhong, R. Z., & Zhou, D. W. (2013). Oxidative stress and role of natural plant derived antioxidants in animal reproduction. Journal of Integrative Agriculture, 12(10), 1826-1838.
14. Melov, S., Schneider, J. A., Day, B. J., Hinerfeld, D., Coskun, P., Mirra, S. S., ... & Wallace, D. C. (1998). A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. Nature genetics, 18(2), 159.
15. Rizzo, A., Roscino, M. T., Binetti, F., & Sciorsci, R. L. (2012). Roles of reactive oxygen species in female reproduction. Reproduction in Domestic Animals, 47(2), 344-352.
16. Agarwal, A., & Allamaneni, S. S. (2004). Role of free radicals in female reproductive diseases and assisted reproduction. Reproductive biomedicine online, 9(3), 338-347.
17. Stier, A., Reichert, S., Massemin, S., Bize, P., & Criscuolo, F. (2012). Constraint and cost of oxidative stress on reproduction: correlative evidence in laboratory mice and review of the literature. Frontiers in zoology, 9(1), 37.
18. Walczak–Jedrzejowska, R., Wolski, J. K., & Slowikowska–Hilczer, J. (2013). The role of oxidative stress and antioxidants in male fertility. Central European journal of urology, 66(1), 60.
19. Agarwal, A., Aponte-Mellado, A., Premkumar, B. J., Shaman, A., & Gupta, S. (2012). The effects of oxidative stress on female reproduction: a review. Reproductive biology and endocrinology, 10(1), 49.
20. Aitken, R. J., & Baker, M. A. (2004). Oxidative stress and male reproductive biology. Reproduction, Fertility and development, 16(5), 581-588.
21. Aitken, R. J., & Roman, S. D. (2008). Antioxidant systems and oxidative stress in the testes. Oxidative medicine and cellular longevity, 1(1), 15-24.
22. Agarwal, A., Makker, K., & Sharma, R. (2008). Clinical relevance of oxidative stress in male factor infertility: an update. American journal of reproductive immunology, 59(1), 2-11.
23. Shrilatha, B. (2007). Early oxidative stress in testis and epididymal sperm in streptozotocin-induced diabetic mice: its progression and genotoxic consequences. Reproductive Toxicology, 23(4), 578-587.
24. Demyda, S., & Genero, E. (2011). Developmental competence of in vivo and in vitro matured oocytes: a review. Biotechnology and Molecular Biology Reviews, 6(7), 155-165.
25. El Mouatassim, S., Guerin, P., & Menezo, Y. (1999). Expression of genes encoding antioxidant enzymes in human and mouse oocytes during the final stages of maturation. Molecular Human Reproduction, 5(8), 720-725.
26. Agarwal, A., Gupta, S., & Sharma, R. K. (2005). Role of oxidative stress in female reproduction. Reproductive biology and endocrinology, 3(1), 28.
27. Wang, X., Falcone, T., Attaran, M., Goldberg, J. M., Agarwal, A., & Sharma, R. K. (2002). Vitamin C and Vitamin E supplementation reduce oxidative stress–induced embryo toxicity and improve the blastocyst development rate. Fertility and sterility, 78(6), 1272-1277.
28. Shahidi, F., Janitha, P. K., & Wanasundara, P. D. (1992). Phenolic antioxidants. Critical reviews in food science & nutrition, 32(1), 67-103.
29. Dai, J., & Mumper, R. J. (2010). Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules, 15(10), 7313-7352.
30. Khaki, A., Ouladsahebmadarek, E., Javadi, L., Farzadi, L., Fathiazad, F., & Nouri, M. (2011). Anti-oxidative effects of citro flavonoids on spermatogenesis in rat. African Journal of Pharmacy and Pharmacology, 5(6), 721-725.
31. Halenár, M., Tvrdá, E., Baldovská, S., Ondruška, Ľ., Massányi, P., & Kolesárová, A. In vitro Effects of Viscum album on the Functionality of Rabbit Spermatozoa. World Academy of Science, Engineering and Technology, International Journal of Biological, Biomolecular, Agricultural, Food and Biotechnological Engineering, 11(2), 108-112.
32. Khaki, A., Fathiazad, F., Ahmadi-Ashtiani, H. R., Rastgar, H., & Rezazadeh, S. (2009). Effects of Danae racemosa on Spermatogenesis in Rat. Journal of Medicinal Plants, 3(31), 87-92.
33. Zangeneh, F. Z., Minaee, B., Amirzargar, A., Ahangarpour, A., & Mousavizadeh, K. (2010). Effects of chamomile extract on biochemical and clinical parameters in a rat model of polycystic ovary syndrome. Journal of reproduction & infertility, 11(3), 169.
34. Ofem, O. E. (2014). Enhancement of some sex hormones concentrations by consumption of leaves extract of Viscum album (mistletoe) in rats. Asian Journal of Medical Sciences (E-ISSN 2091-0576; P-ISSN 2467-9100), 5(3), 87-90.
35. Ifeanyi, A. C., Yama, O. E., Ikechukwu, D. F., Adewale, O. A., Noronha, C. C., & Olugbenga, O. A. (2011). Effect of Momordica Charantia on estrous cycle of Sprague-Dawley rats. Pacific Journal of Medical Sciences, 8(1), 37-48.

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Details

Primary Language	Turkish
Subjects	Pharmacology and Pharmaceutical Sciences
Journal Section	Collection
Authors	Serdal Kurt 0000-0002-0191-3245
Publication Date	June 1, 2019
Submission Date	October 18, 2018
Acceptance Date	March 4, 2019
Published in Issue	Year 2019 Volume: 43 Issue: 2

Cite

APA	Kurt, S. (2019). DENEY HAYVANLARINDA FERTİLİTE YÖNÜNDEN BİTKİSEL KAYNAKLI ANTİOKSİDANLARIN KULLANIMI. Journal of Faculty of Pharmacy of Ankara University, 43(2), 197-208. https://doi.org/10.33483/jfpau.472016
AMA	Kurt S. DENEY HAYVANLARINDA FERTİLİTE YÖNÜNDEN BİTKİSEL KAYNAKLI ANTİOKSİDANLARIN KULLANIMI. J. Fac. Pharm. Ankara. June 2019;43(2):197-208. doi:10.33483/jfpau.472016
Chicago	Kurt, Serdal. “DENEY HAYVANLARINDA FERTİLİTE YÖNÜNDEN BİTKİSEL KAYNAKLI ANTİOKSİDANLARIN KULLANIMI”. Journal of Faculty of Pharmacy of Ankara University 43, no. 2 (June 2019): 197-208. https://doi.org/10.33483/jfpau.472016.
EndNote	Kurt S (June 1, 2019) DENEY HAYVANLARINDA FERTİLİTE YÖNÜNDEN BİTKİSEL KAYNAKLI ANTİOKSİDANLARIN KULLANIMI. Journal of Faculty of Pharmacy of Ankara University 43 2 197–208.
IEEE	S. Kurt, “DENEY HAYVANLARINDA FERTİLİTE YÖNÜNDEN BİTKİSEL KAYNAKLI ANTİOKSİDANLARIN KULLANIMI”, J. Fac. Pharm. Ankara, vol. 43, no. 2, pp. 197–208, 2019, doi: 10.33483/jfpau.472016.
ISNAD	Kurt, Serdal. “DENEY HAYVANLARINDA FERTİLİTE YÖNÜNDEN BİTKİSEL KAYNAKLI ANTİOKSİDANLARIN KULLANIMI”. Journal of Faculty of Pharmacy of Ankara University 43/2 (June 2019), 197-208. https://doi.org/10.33483/jfpau.472016.
JAMA	Kurt S. DENEY HAYVANLARINDA FERTİLİTE YÖNÜNDEN BİTKİSEL KAYNAKLI ANTİOKSİDANLARIN KULLANIMI. J. Fac. Pharm. Ankara. 2019;43:197–208.
MLA	Kurt, Serdal. “DENEY HAYVANLARINDA FERTİLİTE YÖNÜNDEN BİTKİSEL KAYNAKLI ANTİOKSİDANLARIN KULLANIMI”. Journal of Faculty of Pharmacy of Ankara University, vol. 43, no. 2, 2019, pp. 197-08, doi:10.33483/jfpau.472016.
Vancouver	Kurt S. DENEY HAYVANLARINDA FERTİLİTE YÖNÜNDEN BİTKİSEL KAYNAKLI ANTİOKSİDANLARIN KULLANIMI. J. Fac. Pharm. Ankara. 2019;43(2):197-208.

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.