GLYCYRRHIZA GLABRA'NIN BAZI TIBBİ ÖZELLİKLERİ (MEYAN KÖKÜ)

Year 2021, Volume: 45 Issue: 3, 524 - 534, 27.09.2021

Falah Saleh Mohammed , Nuh Korkmaz , Mehmet Doğan , Ali Erdem Şabik , Mustafa Sevindik

https://doi.org/10.33483/jfpau.979200

Cited By: 11

Abstract

Amaç: Alternatif tıp, insanlık tarihinde birçok hastalıkla mücadelede önemli bir yere sahiptir. Bu çalışmada Glycyrrhiza glabra L.'nin biyolojik aktivitesi araştırıldı.

Gereç ve Yöntem: Bitkinin kök kısımları etanol ile ekstrakte edildi. Antioksidan ve oksidan potansiyelleri Rel Assay kitleri kullanılarak belirlendi. Antimikrobiyal aktivite, agar seyreltme yöntemi kullanılarak standart bakteri ve mantar suşlarına karşı test edildi. Antiproliferatif aktivite, Lung Carcinoma Cell Line'a (A549) karşı MTT testi ile belirlendi.

Sonuç ve Tartışma: Çalışmalar sonucunda bitkinin TAS değeri 8.770±0.171, TOS değeri 14.590±0.191 ve OSI değeri 0.167±0.005 olarak ölçülmüştür. Bitki ekstraktının 50-200 µg/mL konsantrasyon aralığında standart bakteri ve mantar suşlarına karşı inhibisyonu gözlemlendi. Ayrıca bitki ekstraktının konsantrasyon artışına bağlı olarak güçlü antiproliferatif aktivite gösterdiği belirlendi. Bu çalışmalar sonucunda G. glabra'nın önemli bir doğal antioksidan, antimikrobiyal ve antikanser ajanı olarak kullanılabileceği belirlenmiştir.

Keywords

Antimikrobiyal, antioksidan, antiproliferatif, Glycyrrhiza glabra, tıbbi bitkiler

Supporting Institution

Yok

Project Number

Yok

Thanks

Yok

SOME MEDICINAL PROPERTIES OF GLYCYRRHIZA GLABRA (LICORICE)

Abstract

Objective: Alternative medicine has an important place in the fight against many diseases in human history. The biological activity of Glycyrrhiza glabra L. was investigated in this study.

Material and Method: The root parts of the plant were extracted with ethanol. Antioxidant and oxidant potentials were determined using Rel Assay kits. Antimicrobial activity was tested against standard bacteria and fungus strains using the agar dilution method. Antiproliferative activity was determined by MTT test against Lung Carcinoma Cell Line (A549).

Result and Discussion: As a result of the studies, the TAS value of the plant was measured as 8.770±0.171, TOS value as 14.590±0.191 and OSI value as 0.167±0.005. Inhibition of the plant extract was observed against standard bacteria and fungus strains at ranging from 50-200 µg/mL concentrations. In addition, it was determined that the plant extract displayed strong antiproliferative activity due to the increase in concentration. As a result of these studies, it has been determined that G. glabra can be used as an important natural antioxidant, antimicrobial and anticancer agent.

Keywords

Antimicrobial, antioxidant, antiproliferative, Glycyrrhiza glabra, medicinal plants

Project Number

Yok

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