Gebeliğin ilk üç ayında teşhis edilen COVID-19 hastalığının obstetrik sonuçlara etkisi

This article was retracted on December 31, 2022. https://dergipark.org.tr/en/pub/jgon/article/1219931

Abstract

Amaç: Bu makalenin amacı, ilk trimesterde koronavirüs 2019 hastalığı tanısı alan gebeliklerin maternal, fetal ve obstetrik sonuçlarını analiz etmektir. Yöntemler: Gebeliğin ilk üç ayında COVID-19 tanısı konan ve hastaneye yatırılan hastaların prospektif analizi yapıldı. Gebeliğin sonraki haftalarında obstetrik komplikasyonlar, doğum ve neonatal sonuçlar rapor edildi. Bulgular: Yetmiş beş hastayı çalışmaya dahil ettik. Kovid-19 pozitif olan gebelerin ortalama yaşı 28.2 yıl, ortalama gebelik haftası 9.9 hafta idi. Ortalama doğum haftası 31,65±9,47 idi. Hastaların 27'si erken doğum yaptı. Hiçbir bebekte tüm olgular arasında neonatal Sars Cov-2 pozitifliği yoktu. Şiddetli Covid-19 hastası olan 29 hastanın 15'i erken doğumla sonuçlandı. Sonuç: İlk trimesterinde ağır Covid-19 olan hamile kadınlar, erken doğum, intrauterin fetal ölüm ve perinatal komplikasyon açısından daha yüksek risk altındadır.

Keywords

• covid-19
• sars cov-2 ve gebelik
• ilk trimestırda coronavirus-2019
• erken doğum

The effect of COVID-19 disease diagnosed in the first trimester of pregnancy on obstetric outcomes

This article was retracted on December 31, 2022. https://dergipark.org.tr/en/pub/jgon/article/1219931

Abstract

Aim: The purpose of this article is to analyze the maternal, fetal, and obstetric outcomes of pregnancies diagnosed with coronavirus 2019 disease in the first trimester. Methods: A prospective analysis of patients diagnosed with COVID-19 during the first trimester of pregnancy and hospitalized was performed. Obstetric complications, delivery, and neonatal outcomes were reported in the following weeks of pregnancy. Results: We included seventy-five patients in the study. The mean age of pregnant women, Covid-19 positive, was 28.2 years, and the mean gestational week was 9.9 weeks. The mean delivery week was 31.65±9.47. Twenty-seven of the patients had preterm delivery. There was no neonatal Sars Cov-2 positivity among all the cases in any babies. Fifteen of twenty-nine patients with severe Covid-19 resulted in preterm delivery. Conclusion: Pregnant women with severe Covid-19 in their first trimester are at higher risk of premature birth, intrauterine fetal death, and perinatal complications

Keywords

• covid-19
• sars cov-2 and pregnancy
• coronavirus 2019 in the first trimestr
• preterm birth

References

1. 1. WHO. Coronavirus disease 2019 (COVID-19) Situation Report – 52 [Internet]. p. 1–9. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200312-sitrep-52-covid-19.pdf
2. 2. Zhang Y-Z. Novel 2019 coronavirus genome. Virological org. 2020; 3. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. New England journal of medicine. 2020; 4. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The lancet. 2020;395(10224):565–74.
3. 5. Hui DSC, Zumla A. Severe acute respiratory syndrome: historical, epidemiologic, and clinical features. Infectious Disease Clinics. 2019;33(4):869–89.
4. 6. Rasmussen S, Smulian J, Lednicky J, Wen T, Jamieson DJ. Enfermedad por coronavirus 2019 (COVID–19) y embarazo: lo que los obstetras deben saber. Reseñas de Expertos. 2020;222(5):426–501.
5. 7. Yan J, Guo J, Fan C, Juan J, Yu X, Li J, et al. Coronavirus disease 2019 in pregnant women: a report based on 116 cases. American journal of obstetrics and gynecology. 2020;223(1):111-e1.
6. 8. McIntosh K, Hirsch MS, Bloom A. Coronavirus disease 2019 (COVID-19). UpToDate Hirsch MS Bloom. 2020;5(1). 9. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The lancet. 2020;395(10223):497–506.
7. 10. Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics of coronavirus disease 2019 in China. New England journal of medicine. 2020;382(18):1708–20.
8. 11. Xu H, Huang S, Liu S, Deng J, Jiao B, Ai L, et al. Evaluation of the clinical characteristics of suspected or confirmed cases of COVID-19 during home care with isolation: A new retrospective analysis based on O2O. Available at SSRN 3548746. 2020;

9. 12. Lan L, Xu D, Ye G, Xia C, Wang S, Li Y, et al. Positive RT-PCR test results in patients recovered from COVID-19. Jama. 2020;323(15):1502–3.
10. 13. Of NI, Health. Coronavirus Disease 2019 (COVID-19) Treatment Guidelines [Internet]. Available from: https://files.covid19treatmentguidelines.nih.gov/guidelines/covid19treatmentguidelines.pdf
11. 14. Khalil A, Kalafat E, Benlioglu C, O’Brien P, Morris E, Draycott T, et al. SARS-CoV-2 infection in pregnancy: A systematic review and meta-analysis of clinical features and pregnancy outcomes. EClinicalMedicine. 2020;25:100446.
12. 15. Juan J, Gil MM, Rong Z, Zhang Y, Yang H, Poon LC. Effect of coronavirus disease 2019 (COVID‐19) on maternal, perinatal and neonatal outcome: systematic review. Ultrasound in Obstetrics & Gynecology. 2020;56(1):15–27.
13. 16. WHO COVID-19 Case definition [Internet]. Available from: https://www.who.int/publications/i/item/WHO-2019-nCoV-Surveillance_Case_Definition-2020.2
14. 17. Azap Ö. 5. COVID-19’da hastalık ağırlık tanımları ve yatış kriterleri. COVID-19 Görev Grubu Görüş Raporu. :30.
15. 18. Rosen H, Bart Y, Zlatkin R, Ben-Sira L, Ben Bashat D, Amit S, et al. Fetal and Perinatal Outcome Following First and Second Trimester COVID-19 Infection: Evidence from a Prospective Cohort Study. Vol. 10, Journal of Clinical Medicine . 2021.
16. 19. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology. 2021 Feb;57(2):232–41.
17. 20. Cosma S, Carosso AR, Cusato J, Borella F, Carosso M, Bovetti M, et al. Coronavirus disease 2019 and first-trimester spontaneous abortion: a case-control study of 225 pregnant patients. American journal of obstetrics and gynecology. 2021 Apr;224(4):391.e1-391.e7.
18. 21. la Cour Freiesleben N, Egerup P, Hviid KVR, Severinsen ER, Kolte AM, Westergaard D, et al. SARS-CoV-2 in first trimester pregnancy: a cohort study. Human reproduction (Oxford, England). 2021 Jan;36(1):40–7.
19. 22. Zeng L, Xia S, Yuan W, Yan K, Xiao F, Shao J, et al. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatrics [Internet]. 2020;174(7):722–5. Available from: https://doi.org/10.1001/jamapediatrics.2020.0878
20. 23. Di Mascio D, Sen C, Saccone G, Galindo A, Grünebaum A, Yoshimatsu J, et al. Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19. Journal of perinatal medicine. 2020;48(9):950–8.