HPV Pozitif Kadınlarda ASC-US ve LSIL Sitolojilerinin Klinik Veri ve Kolposkopi Sonuçlarının Karşılaştırılması

Abstract

ÖZET Amaç: Çalışmamızın amacı, yüksek riskli insan papilloma virüs (hrHPV) pozitif kadınlar arasında önemi belirsiz atipik skuamöz hücre (ASC-US) ve düşük dereceli skuamöz intraepitelyal lezyon (LSIL) sitolojisinin klinik verileri ile kolposkopiye yönelik biyopsi (CDB) sonuçlarını karşılaştırmaktır. Gereç ve Yöntem: Çalışmaya 20-67 yaşları arasında ASC-US ve LSIL sitolojisi olan toplam 359 hrHPV pozitif hasta dahil edildi. Katılımcıların yaşı, eğitim durumu, sigara içme durumu, kolposkopi sonuçları ve CDB sayısı değerlendirildi ve klinik veriler biyopsilerin histopatolojik değerlendirmesiyle istatistiksel olarak karşılaştırıldı. Bulgular: hrHPV + ASC-US ve hrHPV + LSIL grupları arasında yaş, medeni durum, eğitim durumu ve sigara içme durumu açısından istatistiksel olarak anlamlı fark yoktu. Her iki grup CDB'lerin histopatolojik sonuçları açısından karşılaştırıldı ve gruplar arasında istatistiksel olarak anlamlı bir fark gözlenmedi. CDB materyali sayısı ve endoservikal küretaj sıklığı hrHPV + LSIL'de hrHPV + ASC-US hastalarına göre anlamlı olarak daha yüksekti. İleri tedavi ihtiyacı açısından iki grup arasında istatistiksel olarak anlamlı fark yoktu. Hem ASC-US hem de LSIL gruplarının takibi sırasında gerçekleştirilen kontrol sitolojisi benign olarak sonuçlandı. Sonuç: HPV pozitifliğinde ASCUS ve LSIL'e yaklaşım benzer şekilde önemlidir. Takip süremiz 1 yıllık bir süreyi içerdiğinden, daha uzun vadeli sonuçların gösterilebilmesi için daha ileri çalışmaların yapılması gerekmektedir.

Keywords

• ASCUS
• LSIL
• KOLPOSKOPİ
• HPV

Comparison of Clinical Data and Colposcopy Results of HPV-positive Women with ASC-US and LSIL

Abstract

ABSTRACT Objective: The aim of our study is to compare the clinical data and colposcopy- directed biopsy (CDB) results of atypical squamous cell of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL) cytology among high risk human papilloma virus (hrHPV) positive women. Materials and Methods: A total of 359 hrHPV-positive patients with ASC-US and LSIL cytology, between 20-67 years of age were included in the study. Participants’ age, education status, smoking status, colposcopy results, and number of CDBs were assessed and clinical data compared with histopathologic evaluation of biopsies statistically. Results: There were no statistically significant differences in terms of age, marital status, education status and smoking status of hrHPV + ASC-US and hrHPV + LSIL groups. Both groups were compared in terms of histopathologic results of CDBs and no statistically significant difference was observed between the groups. The number of CDB material and frequency of endocervical curettage were significantly higher in hrHPV + LSIL than hrHPV + ASC-US patients. There was no statistically significant difference between the two groups in terms of advanced treatment need. Control cytology performed during follow-up of both ASC-US and LSIL groups were resulted as benign. Conclusion: The approach to ASCUS and LSIL is similarly important in HPV positivity. Since our follow up period includes a sort period of 1 year, further studies need to be carried out in order to demonstrate longer term outcomes.

Keywords

• ASCUS
• LSIL
• COLPOSCOPY
• HPV

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