COVID-19 Pozitif Gebelerin Hastaneye İlk Başvurularındaki Demografik, Klinik ve Laboratuvar Verilerinin Değerlendirilmesi

Abstract

Amaç: Acil Servise başvuran gebelerin demografik, klinik ve laboratuvar verilerini değerlendirerek, gebeliğin farklı trimesterlerinde COVİD-19 hastalığının klinik seyrini araştırmak. Gereç ve Yöntemler: Olgular semptomlara ve Sat O2 değerine göre asemptomatik, hafif semptomatik ve şiddetli hastalık olarak 3 grupta incelendi. Lenfopeni, kan testlerinde yüksek CRP, ferritin ve D-dimer seviyeleri kötü prognostik faktörler olarak kabul edildi. Bulgular: COVİD-19'lu 678 gebenin 118'i (%17.4) birinci trimesterde, 261'i (%38.5) ikinci trimesterde ve 299'u (%44.1) üçüncü trimesterdeydi. 120'si sadece covid 19 enfeksiyonuna bağlı olmak üzere toplam 257 (%37,9) COVİD-19 (+) gebe hastaneye yatırıldı. Olguların 57'sinde (%8.4) ağır hastalık saptandı, bunların 29'u (%50.9) 2. trimesterde, 26'sı (%45.6) 3. trimesterdeydi. Ağır hastalık insidansı gebeliğin sonraki haftalarında ilk trimestere göre anlamlı derecede yüksekti (p=0.004). Kötü prognostik laboratuvar kriterlerinin trimesterlere göre dağılımı incelendiğinde, COVİD-19'lu gebelerin %22,9'u ilk trimesterde en az bir kötü prognostik laboratuvar kriterine sahipken, bu oran ikinci ve üçüncü trimesterlerde sırasıyla %41,7 ve %63 idi (p<0.001). Sonuç: Bu çalışmada, COVİD-19 pozitif gebelerde hastalığın seyrinin gebeliğin ileri  haftalarında ilk trimestere göre daha şiddetli olduğunu gözlemledik.

Keywords

• COVİD-19
• gebelik
• trimester

Evaluation of Demographic, Clinic and Laboratory data of COVID-19 (+) Pregnants in their First Admission to Hospital

Abstract

Aim: To investigate the clinical course of COVID-19 in different trimesters of pregnancy by evaluating the demographic, clinical and laboratory data of pregnant women who applied to the Emergency Service. Materials and method: Cases were examined in 3 groups as asymptomatic, mild symptomatic and severe disease according to symptoms and oxygen saturation. High levels of CRP, ferritin, D-dimer and lymphopenia in blood tests were considered as poor prognostic factors. Results: Of 678 pregnant women with COVİD-19 , 118 (17.4%) were in the first trimester, 261 (38.5%) were in the second trimester and 299 (44.1%) were in the third trimester. A total of 257 (37.9%) COVID-19 (+) pregnant women were hospitalized and 120 of them were due to COVID-19 infection without any obstetric indication. Severe disease was detected in 57 (8.4%) of the cases; 29 of them (50.9%) were in the 2nd trimester and 26 (45.6%) were in the 3rd trimester. The incidence of severe disease was statistically significantly higher in the later weeks of pregnancy compared to the first trimester (p=0.004). When the distribution of the poor prognostic laboratory criteria according to trimesters was examined, 22.9% of pregnant women with COVID-19 had at least one poor prognostic laboratory criterion in the first trimester, while this rate was 41.7% and 63.9% in the second and third trimesters, respectively (p<0.001). Conclusion: In this study, we observed that the course of the disease in COVID-19 positive pregnant women is more severe in the later weeks of pregnancy than in the first trimester.

Keywords

• COVID-19
• pregnancy
• trimester

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