Antibiotics for transient tachypnea of newborn; are comorbidities reasons or results?

Abstract

Aim: To compare late preterm and term newborns administered antibiotic treatment and conservative management with the diagnosis of TTN including infectious complications, pulmonary air leak and length of hospital stay. Materials and methods: This prospective study was carried out at Zekai Tahir Burak Women’s Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences. Two hundred and ninety one infants were included in the study and 101 (34.7%) were given antibiotic treatment and 190 (65.3%) were followed with conservative treatment. Results: Infants treated with antibiotics required more noninvasive respiratory support (57% vs 21%, p<0.0001), had a longer duration of hospital stay (7.8±3.6 vs 5.5±3.1 days, P<0.0001), more infectious complications (16.8% vs 0.5%, p<0.0001) and pulmonary air leak complications (8.9% vs 0.5%, p<0.01) than untreated infants. Conclusions: Infants with TTN treated with antibiotics have not only more infectious complications but also more pulmonary air leak than untreated infants. Infants with TTN not treated with antibiotics have a shorter length of hospital stay possibly preventing complications related to longer hospital stay. In the light of our results we emphasize that most infants with TTN receive unnecessary antibiotics.

Keywords

• transient tachypnea,newborn,antibiotics,complications

Yenidoğanın geçici takipnesinde antibiyotikler; Komorbiditeler sebep mi sonuç mu?

Abstract

Amaç: Yenidoğanın geçici takipnesi(YDGT) tanısı alan, antibiyotik tedavisi verilen ve konservatif tedavi uygulanan geç pematüre ve term yenidoğanların, enfeksiyöz komplikasyonlar, pulmoner hava kaçağı ve hastanede kalış süresi açısından karşılaştırılması amaçlanmıştır. Gereçler ve Yöntem: Bu prospektif çalışma, Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi, Sağlık Bilimleri Üniversitesi, Tıp Fakültesi'nde yürütüldü. İki yüz doksan bir bebek çalışmaya dahil edildi ve 101'ine (% 34.7) antibiyotik tedavisi verildi ve 190' ına (% 65.3) konservatif tedavi uygulandı. Bulgular: Antibiyotik ile tedavi edilen bebeklerde, konvansiyonel tedavi ile izlenen bebeklerle karşılaştırıldığında daha fazla non-invaziv solunum desteği gereksinimi (% 57 -% 21, p <0.0001), daha uzun hastanede kalış süresi (7.8 ± 3.6 ve 5.5 ± 3.1 gün, P <0.0001), daha fazla enfeksiyöz komplikasyon (%16.8 ve -% 0.5, p <0.0001) ve pulmoner hava kaçağı komplikasyonları (% 8.9 -% 0.5, p <0.01) olduğu görüldü. Sonuçlar: Antibiyotik ile tedavi edilen YDGT’li bebeklerde enfeksiyöz komplikasyonlar ile birlikte pulmoner hava kaçağı komplikasyonu da daha fazla olduğu görülmüştür. Antibiyotik tedavisi görmeyen YDGT'li bebeklerin hastanede yatış sürelerinin daha kısa olması nedeni ile hastanede uzun süre yatış nedeni ile ortaya çıkabilecek komplikasyonların da önüne geçmesini sağlamıştır. Elde ettiğimiz sonuçlar ışığında, YDGT'li bebeklerin çoğunun gereksiz antibiyotik aldığını düşünmekteyiz.

Keywords

• geçici takipne,yenidoğan,antibiyotik,komplkasyon

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