The Role Of Tocolytic Agents and Calcium Channel Blockers (Nifedipine) In Preterm Birth Management

Abstract

Preterm birth is an important risk factor for neonatal morbidity and mortality. Calcium channel blockers (nifedipine) are safe and these agents are preferred frequently in medical treatment of preterm labor. Due to lack of license, they may use off-label in the treatment of preterm labor. In this review, current literature on tocolytic agents and nifedipine used in the treatment of preterm delivery is presented.

Keywords

• Preterm birth,tocolysis,calcium channel blockers,nifedipine

Preterm Doğum Yönetiminde Tokolitik Ajanlar ve Kalsiyum Kanal Blokerlerinin (Nifedipin) Yeri

Abstract

Preterm doğum, neonatal morbidite ve mortalite yönünden önemli bir risk faktörüdür. Kalsiyum kanal blokerleri (nifedipin) preterm doğum medikal tedavisinde kullanımı güvenlidir ve uluslararası kılavuzlarda sık tercih edilen ajanlardan birisidir. Ruhsatlanımı olmaması nedeniyle preterm doğum tedavisinde endikasyon dışı (off-label) kullanılmaktadır. Bu derlemede preterm doğum tedavisinde kullanılan tokolitik ajanlar ve nifedipin ile ilgili güncel literatür sunulmuştur.

Keywords

• Preterm doğum,tokoliz,kalsiyum kanal blokerler,nifedipin

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