Evaluation Of The Relationship Between Congenital Hypothyroidism And Mortality In Very Low Birth Weight Preterms

Abstract

Aim: Low thyroid hormones can increase the mortality of critical patients involving adults and children. It is not yet known whether premature infants with congenital hypothyroidism CH present a risk to mortality. In our study, we aimed to investigate the relationship between mortality and CH in premature infants with very low birth weight VLBW

Keywords

• Congenital hypothyroidism,mortality,premature,thyroid function test,very low birth weight

Çok Düşük Doğum Ağırlıklı Prematürelerde Konjenital Hipotiroidi İle Mortalite İlişkisinin Değerlendirilmesi

Abstract

Amaç: Tiroid hormonlarının düşüklüğü ile kritik hastaların mortalitesini artırabildiği erişkin ve çocuk hastalarda belirtilmiştir. Yalnız konjenital hipotiroidi KH olan prematüre hastaların KH olmayan hastalara göre mortalite açısında risk teşkil edip etmediği henüz bilinmemektedir. Çalışmamızda, çok düşük doğum ağırlıklı ÇDDA

Keywords

• Çok düşük doğum ağırlığı,konjenital hipotiroidi,mortalite,prematüre,tiroid fonksiyon testi

References

1. 1. Heidari Z, Feizi A, Hashemipour M, Kelishadi R, Amini M. Growth development in children with congenital hypothyroidism: the effect of screening and treatment variables-a comprehensive longitudinal study. Endocrine 2016; 54:448-459.
2. 2. Baysal BT, Baysal B, Genel F, Erdur B, Ozbek E, Demir K, et al. Neurodevelopmental Outcome of Children with Congenital Hypothyroidism Diagnosed in a National Screening Program in Turkey. Indian Pediatr 2017; 54:381-384.
3. 3. Osborn DA, Hunt RW. Prophylactic postnatal thyroid hormones for prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev 2007; (1):CD005948.
4. 4. LaFranchi S. Thyroid function in the preterm infant. Thyroid 1999; 9:71-8.
5. 5. Hashemipour M, Hovsepian S, Ansari A, Keikha M, Khalighinejad P, Niknam N. Screening of congenital hypothyroidism in preterm, low birth weight and very low birth weight neonates: A systematic review. Pediatr Neonatol 2018; 59:3-14.
6. 6. Dhital R, Poudel DR, Tachamo N, Gyawali B, Basnet S, Shrestha P, et al. Ischemic Stroke and Impact of Thyroid Profile at Presentation: A Systematic Review and Meta-analysis of Observational Studies. J Stroke Cerebrovasc Dis 2017; 26:2926-2934.
7. 7. Akirov A, Shochat T, Shechvitz A, Shimon I, Diker-Cohen T, Robenshtok E. Pre-admission TSH levels predict long-term mortality in adults treated for hypothyroidism. Endocrine 2017; 58:481-487.
8. 8. Weng CH, Chen YH, Lin CH, Luo X, Lin TH. Thyroid disorders and breast cancer risk in Asian population: a nationwide population-based case-control study in Taiwan. BMJ Open 2018 ;8:e020194.

9. 9. Wang F, Pan W, Wang H, Wang S, Pan S, Ge J. Relationship between thyroid function and ICU mortality: a prospective observation study. Crit Care 2012; 16:R11.
10. 10. Suvarna JC, Fande CN. Serum thyroid hormone profile in critically III children. Indian J Pediatr 2009; 76:1217-21.
11. 11. Hatipoglu N, Büyükkayhan D, Kurtoglu S. Yenidogan Dönemi Tiroid Hastalıkları. Turkiye Klinikleri J Pediatr Sci 2006; 2:63-82.
12. 12. Kurt A, Aygun AD, Sengul I, Sen Y, Citak Kurt AN, Ustundag B. Serum thyroid hormones levels are significantly decreased in septic neonates with poor outcome. J Endocrinol Invest 2011; 34:e92-6.
13. 13. Rogers EE, Hintz SR. Early neurodevelopmental outcomes of extremely preterm infants. Semin Perinatol 2016; 40:497-509.
14. 14. Vigone MC, Caiulo S, Di Frenna M, Ghirardello S, Corbetta C, Mosca F, et al. Evolution of thyroid function in preterm infants detected by screening for congenital hypothyroidism. J Pediatr 2014; 164:1296-302.
15. 15. Lee JH, Kim SW, Jeon GW, Sin JB. Thyroid dysfunction in very low birth weight preterm infants. Korean J Pediatr 2015; 58:224-9.
16. 16. American Academy of Pediatrics, Rose SR; Section on Endocrinology and Committee on Genetics, American Thyroid Association, Brown RS; Public Health Committee, Lawson Wilkins Pediatric Endocrine Society, Foley T, Kaplowitz PB, Kaye CI, Sundararajan S, Varma SK. Update of newborn screening and therapy for congenital hypothyroidism. Pediatric 2006; 117:2290-303.
17. 17. Guy VV, Johnny D. Disorders of the thyroid in the newborn and infant. In: Sperling MA, editor. Pediatric endocrinology. 4th ed. Philadelphia (PA): Saunders, 2014. p. 186-208.
18. 18. Ericson JE, Laughon MM. Chorioamnionitis: implications for the neonate. Clin Perinatol 2015; 42:155-65, ix.
19. 19. Männistö T, Mendola P, Reddy U, Laughon SK. Neonatal outcomes and birth weight in pregnancies complicated by maternal thyroid disease. Am J Epidemiol 2013; 178:731-40.
20. 20. Taşcı Hİ, Erikoğlu M, Toy H, Karaibrahimoğlu A. Course of sepsis in rats with thyroid dysfunction. Turk J Surg 2017; 33:175-179.
21. 21. Dembinski J, Arpe V, Kroll M, Bartmann P, Hieronimi G. Thyroid function in healthy and sick very-low-birth-weight infants--thyrotropin and free thyroxine levels until the sixth week of age. Biol Neonate 2001; 80:210-4.
22. 22. Ryckman KK, Spracklen CN, Dagle JM, Murray JC. Maternal factors and complications of preterm birth associated with neonatal thyroid stimulating hormone. J Pediatr Endocrinol Metab 2014; 27:929-38.
23. 23. Kantor MJ, Leef KH, Bartoshesky L, Getchell J, Paul DA. Admission thyroid evaluation in very-low-birth-weight infants: association with death and severe intraventricular hemorrhage. Thyroid 2003; 13:965-9.