The Effect of Antenatal Nifedipine Administration on Patent Ductus Arteriosus

Abstract

Aim: In his study, we aimed to determine the effect of antenatal nifedipine application on haemodynamicaly significant PDA hsPDA in very low birth weight VLBW premature infants.Material and Methods: We retrospectively evaluated the medical records of very low birth weight VLBW infants between January 2013 and December 2016.The demographic and clinical characteristics of the infants were recorded. The preterms included in the study were divided into two groups as with hsPDA and without hsPDA. Demographic, clinical features and nifedipine administration were compared between two groups.Results: A total of 602 VLBW infans were included. Two hundred fifty-seven 42.7% infants had hsPDA, and 11 1.8% of them treated with PDA ligation. The rate of administration of antenatal nifedipine in the hsPDA group was significantly higher than the rate of antenatal nifedipine administration in the non-hsPDA group . %46,7 vs %31,3; p

Keywords

• Patent ductus arteriosus,premature,very low birth weight,nifedipine

Antenatal Nifedipin Kullanımının Patent Duktus Arteriozusa Etkisi

Abstract

Amaç: Çalışmamızda çok düşük doğum ağırlıklı ÇDDA prematürelerde antenatal nifedipin uygulanmasının hemodinamik anlamlı patent duktus arteriozus haPDA üzerine etkisini belirlenmesi amaçlanmıştır.Gereç ve Yöntemler: Çalışmamızda Ocak 2013 ile Aralık 2016 tarihleri arasında ünitemizde izlenen, ÇDDA bebekler retrospektif olarak incelendi. Bebeklerin demografik ve klinik özellikleri kayıt edildi. Çalışmaya dahil edilen prematürelerin haPDA’sı olan ve olmayanlar olarak iki gruba ayrılarak, demografik, klinik özellikleri ve antenatal nifedipin uygulanması açından karşılaştırıldı.Bulgular: Toplam 602 ÇDDA bebeğin dahil edildiği çalışmamızda, 257 bebekte %42,7 haPDA saptandı ve 11 hastaya %1,8 PDA ligasyonu uygulandı. Hemodinamik anlamlı PDA grubunda antenatal nifedipin uygulanma oranı, haPDA olmayan gruptaki antenatal nifedipin uygulanma oranına göre istatistiksel olarak anlamlı yüksek tespit edildi %46,7 ve %31,3; p

Keywords

• Patent duktus arteriozus,prematüre,çok düşük doğum ağırlığı,nifedipin

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