To Which Patients Should Intrauterine HCG Injection Be Applied In In Vitro Fertilization?

Abstract

Aim: To investigate the impact of the intrauterine injection of hCG before embryo transfer in in vitro fertilization IVF according to number of transfer.Material And Methods: One hundred and sixty-eight 168 patients were included to the study group; 274 patients were included to the control group. The patients were divided into 2 study and 2 control groups.Group 1: Study group patients in the first and the second IVF cycles. N=126 Group 2: Control group patients in the first and the second IVF cycles. N=189 Group 3: Study group patients in the third or more IVF cycles. N=42 Group 4: Control group patients in the third or more IVF cycles. N=85 Fresh IVF-embryo transfer ET was performed to all patients. Intrauterine hCG injection was performed before ET in the study groups.Results: The pregnancy, clinical pregnancy and implantation rates were significantly increased in the intrauterine hCG injected patients with third or more IVF cycles p= 0.03, p= 0.02, p= 0.02 respectively.Conclusion: The intrauterine hCG injection improved the pregnancy rates in the patient with recurrent IVF failures.

Keywords

• Intrauterine hCG,infertility,IVF,recurrent IVF failures,hCG

İntrauterin HCG Enjeksiyonu IVF' te Hangi Hastalara Uygulanmalıdır?

Abstract

Amaç: İn vitro fertilizasyon IVF tedavisinde embryo transferinden önce yapılan intrauterin human chorionic gonadothropin enjeksiyonlarının etkisinin değerlendirilmesi amaçlanmıştır.Gereç ve Yöntemler: Yüz atmış sekiz hasta çalışma grubuna alındı. 274 hasta ise kontrol grubuna dahil edildi. Hasta grupları kendi içinde de ikiye ayrıldı.Grup 1: Birinci ve ikinci IVF denemesi olan çalışma grubu hastaları N:126 Grup 2: Birinci ve ikinci IVF denemesi olan control grubu hastaları N:189 Grup 3: Üç veya daha fazla IVF denemesi olan çalışma grubu hastaları N:42 Grup 4: Üç veya daha fazla IVF denemesi olan control grubu hastaları. N:85 .Tüm hastalara taze embryo transferi ET yapıldı. Çalışma grubuna ET öncesi intrauterine hcg enjeksiyonu uygulandı.Bulgular: Üç veya daha fazla sayıda IVF uygulaması yapılmış hastalarda gebelik, klinik gebelik ve implantasyon oranları intrauterine hCG enjekte edilenlerde belirgin düzeyde yüksek çıkmıştır. p=0,03, p=0,02, p=0,02 sırasıyla Sonuç: Intrauterin hCG enjeksiyonu tekrarlayan IVF başarısızlığı olan hastalarda gebelik oranlarını iyileştirmektedir.

Keywords

• Intrauterin hCG,infertilite,tekrarlayan IVF başarısızlığı,hCG

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