Analaysis Of Stage 3C Endometroid Type Endometrium Cancer: Is There Any Survival Difference Between Stage IIIC1 And IIIC2 ?

Abstract

Aim: The objective of this study was to compare the survival outcomes of stage IIIC1 and IIIC2 endometrioid type endometrial cancer and to share our single center experience.Material and Methods: The patients who underwent complete surgical staging and diagnosed as stage IIIC endometrioid type endometrial cancer after final histopathological examination were included in this study. A total of 47 women were included in this retrospective study. The patients were divided into two groups. The patients with stage IIIC1 n=21, 44.7 % were included in Group 1 whereas the patients with stage IIIC2 n=26, 55.3 % were included in Group 2.Result: The median age of the patients was 61 34-74 . There was also no statistically significant difference between the two groups in terms of age, peritoneal cytology, lymphovascular space involvement, tumor diameter, depth of myometrial invasion, FIGO grade, number of positive lymph nodes, preoperative serum CA-125 level, cervical stromal involvement and adnexial involvement p>0.05 . There was no statistically significant difference in terms of disesase-free survival DFS and overall survival OS between the two groups. Five-year DFS rates were 53.9 % in Group 1 and 49.3 % in Group 2, respectively p=0.915 . Five-year of OS rates were found to be 53.1 % in Group 1 and 60.5 % in Group 2, respectively p=0.664 .Conclusion: The relationship between lymph node involvement and survival in advanced stage endometrioid endometrial cancer is controversial in the current literature and our study did not show any survival difference between stage IIIC1 and IIIC2 disease.

Evre 3C Endometrioid Tip Endometrium Kanserlerinin Analizi: Evre IIIC1 ve Evre IIIC2 Arasında Sağ Kalım Farkı Var mı?

Abstract

Amaç: Bu çalışmanın amacı evre IIIC1 ve IIIC2 endometrioid tip endometrium kanserinin genel ve hastalıksız sağ kalım analizlerini karşılaştırarak tek merkez deneyimimizi aktarmaktır.Gereç ve Yöntem: Kliniğimizde cerrahi olarak komplet evrelenmiş ve histopatolojik inceleme sonucunda evre IIIC tanısı alan endometrioid tip endometrium kanseri tanısı alan olgular n=47 çalışmaya dâhil edildi. Olgular iki gruba ayrıldı. Grup 1’e evre IIIC1 tanısı konulan hastalar n=21, %44,7 alınırken, Grup 2’de ise evre IIIC2 tanısı konulan olgular n=26, %55,3 yer aldı. Hastaların ortanca yaşı 61 34-74 idi. İki grup arasında yaş, sitoloji, lenfovasküler alan invazyonu, tümör çapı, miyometrial invazyon derinliği, grade, lenf nodu sayısı, serum Ca-125 seviyesi, servikal stromal tutulum ve adneksial tutulum açısından anlamlı bir fark izlenmedi p>0.05 . İki grup arasında hastalıksız sağ kalım DFS ve genel sağkalım OS açısından anlamlı farklılık bulunamadı. Beş yıllık DFS oranları ise sırasıyla % 53,9 ve % 49,3 olarak bulundu p=0.915 . 5 yıllık OS oranları sırası ile % 53,1 ve % 60,5 olarak tespit edildi p= 0.664 . Çalışmamızda evre IIIC1 ve evre IIIC2 olguları arasında onkolojik akıbet açısından fark bulunmadı.Sonuç: Çalışmamızda evre IIIC1 ve evre IIIC2 endometrioid tip endometrium kanserli olguların hastalıksız sağkalım ve genel sağkalım açısından anlamlı fark bulunmadı.

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