Environmental And Occupational Exposure to Toxicants As Risk Factor For Neural Tube Defects

Abstract

Aim: Neural tube defects NTD constitute one of the most common congenital malformations of the central nervous system which originate during embryogenesis. The failure in the morphogenetic process of neural tube closure results with NTD. Genetic and environmental factors play role in the pathogenesis of NTD. Gene polymorphisms in folate metabolism is accepted as the primary determinant while environmental and occupational factors contribute to etiology. A number of epidemiologic and clinical studies have investigated the potential association between environmental and occupational exposure to noxious chemicals and NTD. We reviewed some of these studies which have investigated the potential etiological role of heavy metals lead, arsenic, mercury, cadmium and manganese , pesticides, solvents and polycyclic aromatic hydrocarbons in NTD.

Keywords

• Neural tube defects include heavy metal,pesticide,solvent,polycyclic aromatic hydrocarbon

Nöral Tüp Defekti Risk Faktörü Olarak Çevresel ve Mesleki Toksik Madde Maruziyeti

Abstract

Amaç: Nöral tüp defektleri NTD embriyonik gelişim esnasında ortaya çıkan ve santral sinir sisteminin en sık rastlanan doğumsal anomalisidir. Nöral tüpün morfogenetik kapanmasındaki bozukluk NTD ile sonuçlanır. NTD patogenezinde genetik ve çevresel faktörler rol alır. NTD etiyolojisinde folat metabolizmasındaki gen polimorfizmleri asıl etken olarak kabul edilirken çevresel ve mesleki faktörlerin de katkısı vardır. Çok sayıda epidemiyolojik ve klinik araştırmada NTD ile çevresel ve mesleki toksik madde maruziyeti ilişkisi incelenmiştir. Bizler bu makalede NTD etiyolojisinde ağır metaller kurşun, arsenik, civa, kadmiyum, ve manganez , pestisitler, solventler ve polisiklik aromatik hidrokarbonların etkilerini inceleyen çalışmaları derledik.

Keywords

• Nöroal tüp defektleri,ağır metal,pestisit,solvent,polisiklik aromatik hidrokarbon

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