The Diagnostic Utility Of Clinical Features And Tumor Marker Levels In Patients With Ovarian Mature Cystic Teratoma

Abstract

Aim: The aim of this study is to evaluate the effect of clinical features and tumor marker levels to preoperative diagnosis in patients with ovarian mature cystic teratomas MCT .Material and Methods: Demographic features, clinical features and tumor markers of 201 patients, who were operated at our hospital from 2012 to 2015 and confirmed pathologically as having ovarian MCT were evaluated retrospectively. Age of the patients, gravida, parity, menopausal status, bilaterality, clinical symptoms, operation type and tumor marker levels are evaluated and expressed as mean± standard deviation, and percents.Results: The mean age of the patients was 34, 76 ±12,83 years. 79,7% of the patients were at reproductive age group. 13,4% of the patients were at post menoposal age, 4,4% of the patients were pregnant and 2,5% of the patients were at premenarchial period. Bilaterality rate was 10,2%. The most common clinical symptom was pelvic pain with 67,7% and laparoscopy was with 68,2% the most common operation performed. Mean tumor marker levels like AFP, CEA, Ca 19-9 and Ca-125 were 4,0; 1,5; 18,5 and 29,4 IU/ml, respectively.Conclusion: Clinical features especially ultrasound have been shown to be significant markers for the diagnosis of ovarian MCT. We believe a good clinical evaluation preoperatively will make the main contribution to the diagnosis.

Keywords

• Mature cystic teratoma,ovary,tumor marker,clinical findings

Ovaryan Matür Kistik Teratom Olgularında Tanıya Yaklaşımda Tümör Belirteçlerinin ve Klinik Özelliklerin Önemi

Abstract

Amaç: Bu çalışmanın amacı ovaryan matür kistik teratomlu MKT olgulardaki klinik özelliklerin ve tümör belirteçlerinin preoperatif tanıya olan etkilerinin araştırılmasıdır.Gereç ve Yöntemler: Hastanemizde 2012-2015 tarihleri arasında opere edilen ve kesin patoloji sonucu ovaryan MKT olan 201 hastanın demografik, klinik özellikleri ve tümör markerları retrospektif olarak taranmıştır. Hastaların yaş, gravida, parite, menapozal durum, bilateralite, klinik semptom, yapılan operasyonun şekli ve tümör marker seviyeleri değerlendirilerek sonuçlar, ortalama ± standart deviasyon ve yüzdelik dilimler olarak belirtilmiştir.Bulgular: Hastaların ortalama yaşı 34,76 ±12,83 olarak saptandı. Reprodüktif dönemde olan hasta oranı %79,7 iken, % 13,4’ü postmenopozal dönemde, %4,4‘ü gebe kalan %2,5 ise premenarşal dönemdeydi. Bilateralite oranı %10,2 saptandı. En sık klinik semptom %66,7 ile kasık ağrısı ve en sık yapılan operasyon şekli %68,2 ile laparoskopiydi. Tümör markerlarından AFP, CEA, Ca 19-9 ve Ca-125 ortalama seviyeleri sırasıyla 4,0; 1,5; 18,5 ve 29,4 IU/ml olarak tespit edildi.Sonuç: Ovaryan MKT’ların tanısında başta ultrasonografi olmak üzere, klinik özelliklerin önemli belirteçler olduğu görülmüştür. Preoperatif dönemde iyi bir klinik değerlendirme yapılmasının, tanıya en çok katkıyı sağlayacağı kanaatindeyiz.

Keywords

• Matür kistik teratom,over,tümör marker,klinik bulgular

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