The Role of Ultrasonographic Markers for Prediction of First Trimester Pregnancy Outcomes

Abstract

Aim: To examine certain ultrasonographic parameters during the first trimester of pregnancy and determining their role to predict first trimester outcome.Material and Methods: It’s a prospective cohort study including 210 pregnant women that admitted to antenatal care unit of Etlik Zübeyde Hanım Women’s Health Training and Research Hospital. Patients’ gestational age were calculated according to last menstrual period. Embryonic heart rate and yolk sac diameter were evaluated ultrasonographically during the first 12 weeks of pregnancy and then patients who have lost their conceptus were confronted with non-aborted ones at the end of 12 weeks of pregnancy. Mono-directional variance analysis was used to determine the correlation between yolk sac diameter and menstrual age, also between embryonic heart rate and menstrual age. Menstrual Age minus Mean Sac Diameter related Age , ‘Yolk Sac Diameter/Mean Sac Diameter ratio’, ‘ Mean Sac Diameter minus Crown-Rump Length ’ were compared between ‘the group of first trimester aborted’ and ‘the group of first trimester non-aborted’ with Independent T-Test. Regression analysis was performed for parameters, suitable graphs and curves were drawn. Fisher Exact Test was performed to determine the decisiveness of ‘Embrional Heart Rate < 120/ minute’ and ‘ Menstrual Age minus Mean Sac Diameter related Age ’ values.Results: Yolk sac diameter was decisive to predict abortion except 6-8 weeks of first trimester pregnancy p≤0.001 . Yolk sac diameters were increasing as gestational sac diameter and CRL Crown-Rump Length increased. Embryonic heart rate lesser than 120 pulse per minute was substantially decisive to predict abortion in all groups p

Keywords

• Marker,first trimester,embryonic heart rate,ultrasonography

Ultrasonografik Belirteçlerin İlk Trimester Gebelik Sonuçlarını Öngörmedeki Rolü

Abstract

Amaç: İlk trimester boyunca bazı ultrasonografik parametrelerin incelenmesi ve ilk trimester gebelik sonuçlarını öngörmedeki rolünü araştırmak.Gereç ve Yöntemler: Etlik Zübeyde Hanım Kadın Hastalıkları Eğitim Araştırma Hastanesi gebe polikliniğinde 210 kadını içeren prospektif kohort çalışması gerçekleştirildi. Gestasyonel yaş, son adet tarihine SAT dayalı olarak hesaplandı. Embriyonel kalp atım hızı EKAH ve yolk kese çapı ilk 12 hafta boyunca değerlendirildi ve takiben gebelikler ilk trimesterin ötesinde devam edenler ve spontan abortus ile sonuçlananlar arasında karşılaştırıldı. Tek yönlü varyans analizi yolk kese çapı ve menstrüel yaş SAT’a göre yaş arası ilişkiyi, EKAH ve menstruel yaş arası ilişkiyi değerlendirmek için kullanıldı. SAT yaşı - OKÇ Ortalama Kese Çapı yaşı farkı, Yolk kese çapının OKÇ’na oranı, OKÇ-CRL CRL Crown-Rump Length : Baş-popo mesafesi farkı düşük yapan ve yapmayan grupta bağımsız t-testi ile karşılaştırıldı. Parametreler için regresyon analizi uygulandı ve uygun eğrileri çizildi. Fisher Exact testi, EKAH 5,5 gün değerinin belirleyiciliği için kullanıldı.Bulgular: Yolk kesesi çapı tüm gruplarda bakıldığında anlamlı farklılık 6-8 hf dışındaki gebelerde saptandı p≤0.001 . Yolk kesesi çapı, gestasyonel kese çapı ve CRL uzunluğu arttıkça artmaktadır. EKAH açısından düşük yapan hastalarla, gebeliği 12 haftanın ötesinde devam edenler arasında anlamlı farklılık saptandı p

Keywords

• Belirteç,ilk trimester,embriyonik kalp hızı,ultrasonografi

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