The Utility of Acute Phase Reactants For Predicting Preterm Delivery in Cases With Threatened Preterm Labor

Abstract

Aim: To determine the utility of selected acute phase reactants to predict preterm delivery occurrence in patients with a diagnosis of threatened preterm labor.Material and Methods: Ninety one pregnant women aged 17-38 years and between 26 and 36+6 weeks of gestational age according to last menstrual period were included in the study. A control group comprising 83 healthy singleton pregnant women in similar gestational ages without any medical or obstetrical problems was included. The study group was further divided into two subgroups which had preterm delivery and term delivery. A total of three groups including controls were studied. The serum levels of zinc, copper, albumin, micro-C-reactive protein, ferritin and complete blood count were analyzed. Also, urinalysis and urine culture tests were performed for all participants. Groups were compared for acute phase reactants and p values less than 0.05 were considered statistically significant.Results: Study and control groups did not have any statistically significant difference in terms of gravidity, abortion, live births, maternal age and maternal body mass index p>0.05 . Forty-five 49.4% women in the study group had term delivery, whereas forty-six 50.6% had preterm delivery. Levels of albumin were statistically lower in the study group whereas ferritin levels were higher p0.05 .Conclusion: The study showed that low serum albumin and high ferritin levels had an association with preterm delivery. These parameters can be used as additional markers with interleukin-6 and fetal fibronectin for preterm delivery prediction. Future studies with larger sample sizes are needed to clarify the association between acute phase reactant levels and preterm delivery prediction.

Keywords

• Preterm delivery,albumin,ferritin,acute phase reactants

Preterm Eylem Tehdidi Olgularında Akut Faz Reaktanlarının Preterm Doğumu Öngörmedeki Yeri

Abstract

Amaç: Preterm eylem tehdidi tanısı almış gebelerde, akut faz reaktanlarının preterm doğumu öngörmedeki yerini araştırmak.Gereç ve Yöntemler: Çalışmaya son adet tarihine göre hesaplanmış 26 hafta ile 36 hafta 6 gün arası gestasyonel yaştaki preterm eylem tehdidi tanısı alan 17- 38 yaş arasındaki 91 gebe dahil edilmiştir. Kontrol grubu olarak, aynı tarihler arasında, benzer gebelik haftasında, herhangi bir medikal veya obstetrik problemi olmayan 83 tekiz gebe alınmıştır. Çalışma grubu kendi içinde terme ulaşan ve preterm doğumla sonuçlanan iki grup ve kontrol grubuyla birlikte üç gruba ayrılmıştır. Gebelerden serum çinko, bakır, albümin, mikro C-reaktif protein, ferritin ve tam kan sayımı tetkikleri gönderilmiş olup ayrıca tam idrar tahlili ve idrar kültürü tetkikleri yapılmıştır. Gruplar akut faz reaktanları açısından karşılaştırılmış p0.05 . Çalışma grubundaki 91 gebenin kırk beşi % 49.4 termde doğum yaparken, kırk altısı % 50.6 preterm doğum yapmıştır. Çalışma grubunda albümin düzeyleri istatistiksel anlamlı düşük bulunurken, ferritin düzeyleri ise anlamlı olarak yüksek saptandı p0.05 .Sonuç: Çalışmamızda artmış ferritin ve azalmış albümin düzeylerinin preterm doğumla ilişkili olabileceği gösterilmiştir. Bu parametreler interlökin-6 ve fibronektine ek bir marker olarak kullanılabilir. Akut faz reaktanlarının, preterm doğumu öngörüsünde kullanılması için bu konuda yapılacak daha geniş çalışmalara ihtiyaç vardır.

Keywords

• preterm doğum,albümin,ferritin,akut faz reaktanları

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