Can Cloasma Be Predicted By 2nd Trimester Screening Tests?

Abstract

Aim: The relationship between melasma formation and increasing hormones during pregnancy is apperent. Our aim is to research the relation of pregnant women’s melasma formation and hormone levels of second trimester scanning test E3, AFP, β-HCG .Material and Methods: 91 primigravide miad pregnants is included to study. 47 of pregnants had cloasma and 44 of pregnants had not cloasma. Two groups are compared for E3, AFP, β-HCG levels, skin colour, family story, allergy story, cigarette usage, oral contraceptive OKS usage and sun protective usage, vitamin usage, mother profession and baby sex.Results: No difference is detected between two groups for hormon levels. Higher male baby and family story rate were statistically significant for the group with cloasma p=0,015, p=0,011 .Conclusion: The hormone levels of second trimester scanning test do not inform for melasma formation. Not only increasing hormone levels during pregnancy but also other factors have affect on melasma formation. The most important of them is family story. Contrary to popular belief, melasma has more relation with male sex.

Keywords

• Melasma,pregnancy,hormons,chloasma,ultraviolet

Kloasma, II. Trimester Tarama Testleriyle Önceden Öngörülebilir Mi?

Abstract

Amaç: Gebelikte melesma oluşumunun, artan hormon düzeyleri ile ilişkisi aşikardır. Amacımız gebe kadınlardaki melesma oluşumunun II. trimester tarama testindeki E3,AFP, β-HCG hormon düzeyleri ile ilişkisini araştırmak.Gereç ve Yöntemler: Çalışmaya 91 primigravid miad gebe dahil edildi. Bunların 47’si kloasması olan ve 44’ü de kloasması olmayan gebelerden oluşuyordu. İki grup, E3,AFP, β-HCG düzeyleri, ten rengi, aile öyküsü, alerji öyküsü, sigara, oral kontraseptif OKS ve güneş koruyucu kullanımı, vitamin kullanımı, anne mesleği ve bebek cinsiyeti açısından karşılaştırıldı.Bulgular: Her iki grupta hormon düzeyleri açısından fark izlenmedi. Kloasması olan grupta erkek bebek oranı ve aile öyküsü oranı istatiksel olarak anlamlı yüksek tespit edildi p=0,015;p=0,011 .Sonuç: II. trimester tarama testindeki hormon düzeyleri melesma gelişimi ile ilgili bize bilgi vermemektedir. Melesma oluşumunda sadece gebelikte artan hormonların değil, diğer faktörlerin de etkisi vardır. Bunların içinde de en önemlisi aile öyküsüdür. Sanılanın aksine melesma daha çok erkek bebek cinsiyeti ile ilgili gözükmektedir.

Keywords

• Melesma,Gebelik,Hormonlar,Kloasma,Ultraviole ışın

References

1. Moin A1, Jabery Z, Fallah N. Prevalence and awareness of melasma du- ring pregnancy. Int J Dermatol 2006 ;45:285-8.
2. Sehgal VN1, Verma P, Srivastava G, Aggarwal AK, Verma S. Melasma: treatment strategy. J Cosmet Laser Ther 2011;13:265-79.
3. McDonald RR, Georgouras KE. Skin disorders in Indo-Chinese immig- rants. Med J Aust 1992;15;156:847-53.
4. Tamega Ade A, Miot LD, Bonfietti C, Gige TC, Marques ME, Miot HA. Clinical patterns and epidemiological characteristics of facial melasma in Brazilian women. J Eur Acad Dermatol Venereol 2013;27:151-6.
5. Bolanca I1, Bolanca Z, Kuna K, Vuković A, Tuckar N, Herman R, Grubisić GColl. Chloasma--the mask of pregnancy. Antropol 2008;32 :139-41.
6. Guinot C1, Cheffai S, Latreille J, Dhaoui MA, Youssef S, Jaber K, Nage- otte O, Doss N. Aggravating factors for melasma: a prospective study in 197 Tunisian patients. J Eur Acad Dermatol Venereol 2010;24:1060-9.
7. Grimes PE. Melasma. Etiologic and therapeutic considerations. Arch Dermatol 1995;131:1453-7.
8. Hexsel D, Rodrigues TC, Dal’Forno T, Zechmeister-Prado D, Lima MM. Melasma and pregnancy in southern Brazil. J Eur Acad Dermatol Venere- ol 2009 ;23:367-8.

9. Jadotte YT1, Schwartz RA. Melasma: insights and perspectives. Acta Dermatovenerol Croat 2010;18:124-9.
10. Cayce KA, McMichael AJ, Feldman SR.Hyperpigmentation: an overview of the common afflictions.Dermatol Nurs 2004;16:401-6, 413-6.
11. Lieberman R, Moy L. Estrogen receptor expression in melasma: results from facial skin of affected patients. J Drugs Dermatol 2008;7:463-5.
12. Resnik S. Melasma induced by oral contraceptive drugs. JAMA 1967 27;199:601-5.
13. Johnston GA, Sviland L, McLelland J. Melasma of the arms associated with hormone replacement therapy. Br J Dermatol 1998;139:932.
14. Varma S, Roberts DL.Melasma of the arms associated with hormone replacement therapy. Br J Dermatol 1999;141:592.
15. McLeod SD1, Ranson M, Mason RS. Effects of estrogens on human melanocytes in vitro.Steroid Biochem Mol Biol 1994;49:9-14.
16. Ranson M, Posen S, Mason RS.Human melanocytes as a target tissue for hormones: in vitro studies with 1 alpha-25, dihydroxyvitamin D3, alp- ha-melanocyte stimulating hormone, and beta-estradiol.J Invest Derma- tol 1988;9:593-8.
17. S. Seité and S. Park. Effectiveness of a Broad-Spectrum Sunscreen in the Prevention of Melasma in Asian Pregnant Women. Journal of Cosmetics, Dermatological Sciences and Applications 2013;3:4-7.