ADAMTS Gen Ailesinin Obstetrik Ve Jinekolojideki Yeri

Abstract

Matrix metalloproteinases with thrombospondin motifs A disintegrin-like and Metalloproteinase with Thrombospondin type-1 motif, ADAMTS firstly described as inflammation-related genes in colon carcinoma by Japanese researchers have a large gene family with the current 19 members. These proteinases which are secreted into extracellular matrix have important roles in matrix formation and degradation, remodeling, coagulation, fibrosis and in many other physiological processes. These enzymes are critical in many pathological situations such as cancers, musculoskeletal disorders and autoimmune events. Recent studies about these proteinases showed their importance in the reproductive system as well. The goal of this review is to provide basic information about the roles of ADAMTS enzymes in the pathophysiology of reproductive system diseases to the researchers of obstetric and gynecology field and to open new insights about this subject.

Keywords

• ADAMTS genes,obstetrics and gynecology,cell matrix

ADAMTS Gen Ailesinin Obstetrik ve Jinekolojideki Yeri

Abstract

1997 yılında Japon araştırmacılar tarafından kolon kanserinde enflamasyon http://www.bilimterimleri.com - ilişkili gen olarak tanımlanan Trombospondin Motifli Matriks Metalloproteinazlarını A Disintegrin-like and Metalloproteinase with Trombospondin type-1 motif; ADAMTS , günümüzde 19 adet üyesiyle büyük bir gen ailesidir. Hücre-dışı matrikse ECM salınan bu enzimlerin matriksin yapım ve yıkımı, dokuların yeniden düzenlenmesi, pıhtılaşma, fibrozis gibi birçok önemli fizyolojik olayda hayati görevleri vardır. Yine kanser, enflamasyon, kas-iskelet sistemi hastalıkları gibi çeşitli klinik durumların patogenezlerinde de önemlidirler. Son çalışmalarla bu enzimlerin üreme sisteminde de önemli fonksiyonlar üstlendiği anlaşılmaya başlandı. Bu derlemenin amacı, obstetrik ve jinekoloji alanında çalışan araştırmacılara ADAMTS’ler hakkında temel bilgileri sunmak ve patofizyolojideki rolleri hakkında son bulguları aktararak yeni çalışmaların önünü açmaktır.

Keywords

• ADAMTS genleri,obstetrik ve jinekoloji,hücre matriksi

References

1. Hynes RO, Naba A. Overview of the matrisome--an inventory of extracellular matrix constituents and functions. Cold Spring Harb Perspect Biol. 2012;4:a004903.
2. Wolfsberg TG, Primakoff P, Myles DG, White JM. ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions. J Cell Biol. 1995;131:275-8.
3. Kuno K, Kanada N, Nakashima E, Fujiki F, Ichimura F, Matsushima K. Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family pro- tein with thrombospondin motifs as an inflammation associated gene. J Biol Chem. 1997;272:556-62.
4. Pyun JA, Kim S, Kwack K. Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure. Menopause. 2014 July, Epub ahead of print.
5. Pyun JA, Kim S, Cha DH, Kwack K. Epistasis between IGF2R and ADAMTS19 poly- morphisms associates with premature ovarian failure. Human Rep. 2013;28:3146-54.
6. Held-Feindt J, Paredes EB, Blomer U, Seidenbecher C, Stark AM, Mehdorn HM, et al. Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloprotei- nases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas. Int J Cancer. 2006; 118:55-61.
7. Dong C, Li HJ, Chang S, Liao HJ, Zhang ZP, Huang P, et al. A Disintegrin and Metallop- rotease with Thrombospondin Motif 2 May Contribute to Cirrhosis in Humans through the Transforming Growth Factor-beta/SMAD Pathway. Gut and liver. 2013;7:213-20. 8. Nandadasa S, Foulcer S, Apte SS. The multiple, complex roles of versican and its prote- olytic turnover by ADAMTS proteases during embryogenesis. Matrix Biol. 2014;35:34-41.
8. Hubmacher D, Apte SS. Genetic and functional linkage between ADAMTS superfamily proteins and fibrillin-1: a novel mechanism influencing microfibril assembly and functi- on. Cell Mol Life Sci. 2011; 68:3137-48.

9. Demircan K, Topcu V, Takigawa T, Akyol S, Yonezawa T, Ozturk G, et al. ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury. Biomed Res Int. 2014;2014:693746.
10. Demircan K, Yonezawa T, Takigawa T, Topcu V, Erdogan S, Ucar F, et al. ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse. Neurosci Lett. 2013;544:25-30.
11. Torres-Collado AX, Kisiel W, Iruela-Arispe ML, Rodriguez-Manzaneque JC. ADAMTS1 interacts with, cleaves, and modifies the extracellular location of the matrix inhibitor tissue factor pathway inhibitor-2. J Biol Chem. 2006;281:17827-37.
12. Canals F, Colome N, Ferrer C, Plaza-Calonge Mdel C, Rodriguez-Manzaneque JC. Iden- tification of substrates of the extracellular protease ADAMTS1 by DIGE proteomic analy- sis. Proteomics. 2006;6 Suppl 1:S28-35.
13. Esselens C, Malapeira J, Colome N, Casal C, Rodriguez-Manzaneque JC, Canals F, et al. The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration. J Biol Chem. 2010;285:2463-73.
14. Choi JE, Kim DS, Kim EJ, Chae MH, Cha SI, Kim CH, et al. Aberrant methylation of ADAMTS1 in non-small cell lung cancer. Cancer Genet Cytogenet. 2008;187:80-4.
15. Diamantis I, Luthi M, Hosli M, Reichen J. Cloning of the rat ADAMTS-1 gene and its down regulation in endothelial cells in cirrhotic rats. Liver. 2000;20:165-72.
16. Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, et al. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. J Biol Chem. 1999;274:23349-57.
17. Wagsater D, Bjork H, Zhu C, Bjorkegren J, Valen G, Hamsten A, et al. ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques. Atherosclerosis. 2008;196:514-22.
18. Drilon A, Sugita H, Sima CS, Zauderer M, Rudin CM, Kris MG, et al. A prospective study of tumor suppressor gene methylation as a prognostic biomarker in surgically resected stage I to IIIA non-small-cell lung cancers. J Thorac Oncol. 2014;9:1272-7.
19. Colige A, Vandenberghe I, Thiry M, Lambert CA, Van Beeumen J, Li SW, et al. Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3.J Biol Chem. 2002;277:5756-66.
20. Bar-Yosef O, Polak-Charcon S, Hoffman C, Feldman ZP, Frydman M, Kuint J. Multiple congenital skull fractures as a presentation of Ehlers-Danlos syndrome type VIIC. Am J Med Genet A. 2008;146A:3054-7.
21. Colige A, Nuytinck L, Hausser I, van Essen AJ, Thiry M, Herens C, et al. Novel types of mutation responsible for the dermatosparactic type of Ehlers-Danlos syndrome (Type VIIC) and common polymorphisms in the ADAMTS2 gene. J Invest Dermatol. 2004;123:656-63.
22. El Khoury L, Posthumus M, Collins M, Handley CJ, Cook J, Raleigh SM. Polymorphic variation within the ADAMTS2, ADAMTS14, ADAMTS5, ADAM12 and TIMP2 genes and the risk of Achilles tendon pathology: a genetic association study. J Sci Med Sport. 2013;16:493-8.
23. Yatabe T, Mochizuki S, Takizawa M, Chijiiwa M, Okada A, Kimura T, et al. Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes. Ann Rheum Dis. 2009;68:1051-8.
24. Valenzuela JC, Heise C, Franken G, Singh J, Schweitzer B, Seidenbecher CI, et al. Hyalu- ronan-based extracellular matrix under conditions of homeostatic plasticity. Philos Trans R Soc Lond B Biol Sci. 2014;369:20130606.
25. Peluffo MC, Murphy MJ, Baughman ST, Stouffer RL, Hennebold JD. Systematic analysis of protease gene expression in the rhesus macaque ovulatory follicle: metalloproteinase involvement in follicle rupture. Endocrinology. 2011;152:3963-74.
26. Westling J, Gottschall PE, Thompson VP, Cockburn A, Perides G, Zimmermann DR, et al. ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein. Biochem J. 2004;377(Pt 3):787-95.
27. Ehlen HW, Sengle G, Klatt AR, Talke A, Muller S, Paulsson M, et al. Proteolytic processing ca- uses extensive heterogeneity of tissue matrilin forms. J Biol Chem. 2009;284:21545-56.
28. Hisanaga A, Morishita S, Suzuki K, Sasaki K, Koie M, Kohno T, et al. A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves Reelin in an iso- form-dependent manner. FEBS letters. 2012;586:3349-53.
29. Weaver MS, Workman G, Cardo-Vila M, Arap W, Pasqualini R, Sage EH. Processing of the matricellular protein hevin in mouse brain is dependent on ADAMTS4. J Biol Chem. 2010;285:5868-77.
30. Zha Y, Chen Y, Xu F, Li T, Zhao C, Cui L. ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes. Biomed Pharmacother. 2010;64:160-4.
31. Zhao C, Zha Y, Wu X, Chen L, Shi J, Cui L. The quantification of ADAMTS4 and 8 expres- sion and selection of reference genes for quantitative real-time PCR analysis in myocar- dial infarction. Biomed Pharmacother. 2011;65:555-9.
32. Bateman JF, Rowley L, Belluoccio D, Chan B, Bell K, Fosang AJ, et al. Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteo- arthritis initiation and cartilage destruction. Arthritis Rheum. 2013;65:1547-60.
33. Nakada M, Miyamori H, Kita D, Takahashi T, Yamashita J, Sato H, et al. Human gli- oblastomas overexpress ADAMTS-5 that degrades brevican. Acta Neuropathol. 2005;110:239-46.
34. McCulloch DR, Nelson CM, Dixon LJ, Silver DL, Wylie JD, Lindner V, et al. ADAMTS metalloproteases generate active versican fragments that regulate interdigital web reg- ression. Dev Cell. 2009;17:687-98.
35. Wierinckx A, Auger C, Devauchelle P, Reynaud A, Chevallier P, Jan M, et al. A diagnostic marker set for invasion, proliferation, and aggressiveness of prolactin pituitary tumors. Endocr Relat Cancer. 2007;14:887-900.
36. Lopez-Mejias R, Genre F, Garcia-Bermudez M, Ubilla B, Castaneda S, Llorca J, et al. Lack of association between ABO, PPAP2B, ADAMST7, PIK3CG, and EDNRA and carotid intima-media thickness, carotid plaques, and cardiovascular disease in patients with rheumatoid arthritis. Mediators Inflamm. 2014;2014:756279.
37. Lai Y, Bai X, Zhao Y, Tian Q, Liu B, Lin EA, et al. ADAMTS-7 forms a positive feed- back loop with TNF-alpha in the pathogenesis of osteoarthritis. Ann Rheum Dis. 2014;73(8):1575-84.
38. Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, et al. ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated vari- ant. Am J Hum Genet. 2013;92(3):366-74.
39. Liu CJ. The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis. Nat Clin Pract Rheumatol. 2009;5:38-45.
40. Kern CB, Wessels A, McGarity J, Dixon LJ, Alston E, Argraves WS, et al. Reduced versi- can cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies. Matrix Biol. 2010;29:304-16.
41. Lo PH, Lung HL, Cheung AK, Apte SS, Chan KW, Kwong FM, et al. Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis. Cancer research. 2010;70:5567-76.
42. Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, et al. Meta-analysis of geno- me-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nature genetics. 2008;40:638-45.
43. Silver DL, Hou L, Somerville R, Young ME, Apte SS, Pavan WJ. The secreted metalloprote- ase ADAMTS20 is required for melanoblast survival. PLoS genetics. 2008;4:e1000003.
44. Tsilou E, MacDonald IM. Weill-Marchesani Syndrome. In: Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, et al., editors. GeneReviews(R). Seattle (WA)1993.
45. Hanby HA, Zheng XL. Current status in diagnosis and treatment of hereditary thrombotic thrombocytopenic purpura. Hereditary genetics : current research. 2014;3(1). pii:e 108
46. Johnston P, Larson D, Clark IM, Chojnowski AJ. Metalloproteinase gene expression cor- relates with clinical outcome in Dupuytren’s disease. J Hand Surg Am. 2008;33:1160-7.
47. Sakamoto N, Oue N, Noguchi T, Sentani K, Anami K, Sanada Y, et al. Serial analysis of gene expression of esophageal squamous cell carcinoma: ADAMTS16 is upregulated in esophageal squamous cell carcinoma. Cancer Sci. 2010;101:1038-44.
48. Kochhar A, Kirmani S, Cetta F, Younge B, Hyland JC, Michels V. Similarity of geleophysic dysplasia and Weill-Marchesani syndrome. Am J Med Genet A. 2013;161A:3130-2.
49. Ohnishi J, Ohnishi E, Shibuya H, Takahashi T. Functions for proteinases in the ovulatory process. Biochim Biophys Acta. 2005;1751:95-109.
50. Shozu M, Minami N, Yokoyama H, Inoue M, Kurihara H, Matsushima K, et al. ADAMTS-1 is involved in normal follicular development, ovulatory process and organization of the medullary vascular network in the ovary. J Mol Endocrinol. 2005;35:343-55.
51. Xiao S, Li Y, Li T, Chen M, Xu Y, Wen Y, et al. Evidence for decreased expression of ADAMTS-1 associated with impaired oocyte quality in PCOS patients. J Clin Endocrinol Metab. 2014;99:E1015-21.
52. Keightley MC, Sales KJ, Jabbour HN. PGF2alpha-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer. BMC cancer. 2010;10:488.
53. Wu Q, Lothe RA, Ahlquist T, Silins I, Trope CG, Micci F, et al. DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets. Mol Cancer. 2007;6:45.
54. Anum EA, Hill LD, Pandya A, Strauss JF, 3rd. Connective tissue and related disorders and preterm birth: clues to genes contributing to prematurity. Placenta. 2009;30:207-15.
55. Bhagwat SR, Redij T, Phalnikar K, Nayak S, Iyer S, Gadkar S, et al. Cell surfactomes of two endometrial epithelial cell lines that differ in their adhesiveness to embryonic cells. Mol Reprod Dev. 2014;81:326-40.
56. Richards JS, Hernandez-Gonzalez I, Gonzalez-Robayna I, Teuling E, Lo Y, Boerboom D, et al. Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation. Biol Reprod. 2005;72:1241-55.
57. Lee SY, Lee HS, Gil M, Kim CJ, Lee YH, Kim KR, et al. Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases. Arch Pathol Lab Med. 2014;138:643-50.
58. Dubail J, Aramaki-Hattori N, Bader HL, Nelson CM, Katebi N, Matuska B, et al. A new Adamts9 conditional mouse allele identifies its non-redundant role in interdigital web reg- ression. Genesis. 2014;52:702-12.
59. Scully MA, Machin SJ. Berend Houwen Memorial Lecture: ISLH Las Vegas May 2009: the pathogenesis and management of thrombotic microangiopathies. Int J Lab Hematol. 2009;31:268-76.
60. Scully M, Starke R, Lee R, Mackie I, Machin S, Cohen H. Successful management of pregnancy in women with a history of thrombotic thrombocytopaenic purpura. Blood Coagul Fibrinolysis. 2006;17:459-63.
61. Marques MB, Mayfield CA, Blackall DP. Thrombotic thrombocytopenic purpura: from platelet aggregates to plasma. Am J Clin Pathol. 2004;121 Suppl:S89-96.
62. Alpoim PN, Gomes KB, Godoi LC, Rios DR, Carvalho MG, Fernandes AP, et al. ADAMTS13, FVIII, von Willebrand factor, ABO blood group assessment in preeclampsia. Clin Chim Acta. 2011;412:2162-6.
63. Stepanian A, Cohen-Moatti M, Sanglier T, Legendre P, Ameziane N, Tsatsaris V, et al. Von Willebrand factor and ADAMTS13: a candidate couple for preeclampsia pathophysio- logy. Arterioscler Thromb Vasc Biol. 2011;31:1703-9.
64. Franchini M, Montagnana M, Targher G, Lippi G. Reduced von Willebrand factor-cleaving protease levels in secondary thrombotic microangiopathies and other diseases. Semin Thromb Hemost. 2007;33:787-97.
65. Pyun JA, Kim S, Cha DH, Kwack K. Epistasis between polymorphisms in TSHB and ADAMTS16 is associated with premature ovarian failure. Menopause. 2014;21:890-5.
66. Knauff EA, Franke L, van Es MA, van den Berg LH, van der Schouw YT, Laven JS, et al. Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene. Human Reprod. 2009;24:2372-8.