Preterm erken membran rüptürü ile komplike olan gebeliklerde seçilen eser elementler ve ağır metallerin maternal serum seviyeleri

Abstract

Amaç: Alüminyum(Al), krom(Cr), manganez(Mn), kobalt(Co), nikel(Ni), bakır(Cu), çinko(Zn), arsenik(As), molibden(Mo), kadmiyum(Cd), kalay(Sn), antimon(Sb), civa(Hg) ve kurşun(Pb) isimli eser element ve ağır metallerin maternal serum seviyelerini, preterm erken membran rüptürü (pP-ROM) ile komplike olmuş gebelerde ve sağlıklı gebelerde karşılaştırmaktır. Gereçler ve Yöntem: pP-ROM ile komplike 55 gebeden oluşan çalışma grubu ile, anne yaşı ve gebelik haftası açısından benzer olan 60 sağlıklı gebenin (kontrol grubu) Al, Cr, Mn, Co, Ni, Cu, Zn, As, Mo, Cd, Sn, Sb, Hg ve Pb serum düzeyleri ölçüldü. Her iki gruptaki eser elementlerin ve ağır metallerin maternal serum seviyeleri, indüktif olarak eşleşmiş plazma kütle spektrometrisi kullanılarak ölçülmüş ve karşılaştırılmıştır. Bulgular: Anne yaşı, vücut kitle indeksi, gebelik sayısı, doğum sayısı ve gebelik haftaları ortalamaları incelendiğinde, iki grupta anlamlı bir fark görülmedi (p≥0.05). Ortalama serum beyaz kan hücresi seviyesi, pP-ROM grubunda sağlıklı kontrollerden daha yüksekti (sırasıyla, 12.2 ± 3.5 LL / mL vs 10.1 ± 2.6 LL / mL; p: 0.001). Ortalama serum C-reaktif protein düzeyi, pP-ROM grubunda sağlıklı kontrollerden daha yüksekti (sırasıyla, 0.99 ± 1.47 mg / L'ye karşılık 0.40 ± 0.27 mg / L; p: 0.003). Ayrıca, ortalama doğum ağırlığı, pP-ROM grubunda sağlıklı kontrollere göre anlamlı derecede düşüktü (sırasıyla 1859 ± 567 gram, 3209 ± 471 gram; p: 0.001). Gruplar arasında Al, Cr, Mn, Co, Ni, Cu, Zn, As, Mo, Cd, Sn, Sb, Hg ve Pb ortalama maternal serum düzeyleri açısından anlamlı fark bulunmadı (p≥0.05). Sonuç: Maternal serumda ölçülen bu seçilmiş eser elementler ve ağır metaller, pP-ROM'un patogenezinde önemli gözükmemektedir.

Keywords

• amniyokoryon
• fetal membranlar
• metal maruziyeti
• gebelik
• erken doğum

Maternal serum concentrations of selected elements in pregnancies complicated with preterm prelabor rupture of membranes

Abstract

Aim: To measure maternal blood elements namely, antimony (Sb), aluminum (Al), arsenic (As), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), manganese (Mn), mercury (Hg), molybdenum (Mo), nickel (Ni), lead (Pb), tin (Sn), and zinc (Zn) in pregnant women complicated by preterm prelabor rupture of the membranes (pP-ROM) and to compare the results with healthy controls. Materials and Methods: Maternal blood concentrations of Al, As, Cd, Co, Cu, Cr, Hg, Mn, Mo, Ni, Pb, Sb, Sn, and Zn were evaluated in the pP-ROM group, which included fifty-five pregnant women complicated with pP-ROM and sixty healthy participants (control group) with respect to gestational weeks and maternal age. The maternal blood concentrations of these elements in both groups were measured using an ICP-MS and also compared. Results: No significant differences regarding gestational week, BMI, parity, gravidity, and maternal age were observed (p≥0.05). The meYan blood white blood cell concentration was higher in the pP-ROM group compared to healthy controls (12.2 ± 3.5 µL/mL vs. 10.1 ± 2.6 µL/mL, respectively; p=0.001). The mean C-reactive protein concentration was higher in the pP-ROM group than the healthy group (0.99 ± 1.47 mg/ Lt vss.. 0,40±0,27 mg/ Lt, respectively; Pp=0.003). There were no differences in terms of mean maternal serum concentrations of Al, As, Cd, Co, Cu, Cr, Hg, Mn, Mo, Ni, Pb, Sb, Sn, and Zn between the study and contrrol grup (P≥0,05). Conclusion: These elements in maternal blood are not involved in the pathogenesis of pP-ROM.

Keywords

• amniochorion
• fetal membranes
• metal exposure
• pregnancy
• premature birth
• white blood cells

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